Tag: Products

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Natural products and their derivatives regulating the janus kinase/signal transducer and activator of transcription pathway.

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Natural products and their derivatives regulating the janus kinase/signal transducer and activator of transcription pathway.

J Asian Nat Prod Res. 2014 Jul;16(7):800-12

Authors: Lin Y, Wang F, Zhang GL

Abstract
Janus kinase/signal transducer and activator of transcriptions (JAK/STAT) signaling pathway is one of the major signaling pathways involved in a variety of human physiological and pathological process. The proteins of JAK/STAT pathway or interferon response element (such as JAK, STAT, Src, SOCS, 2’5′-OAS, and ISRE) might be as drug targets for the study of physiological processes and treatment of related diseases, including cell proliferation, differentiation, apoptosis and immune processes, inflammation, cancer, arthritis, asthma, diabetes, and other diseases. This review attempts to summarize the current status of natural products and their derivatives (2002-2013) regulating the proteins or transcription elements of JAK/STAT signaling pathway to supply a new direction or drug targets for the discovery of new drugs.

PMID: 25076196 [PubMed – in process]

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Effects of Tobacco Products on Live Attenuated Influenza Virus (LAIV) Infections in Human Volunteers

Conditions:   Influenza, Human;   Smoking;   Respiratory Tract Infections;   Habits
Intervention:   Biological: LAIV
Sponsors:   University of North Carolina, Chapel Hill;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI);   Food and Drug Administration (FDA);   Tobacco Centers of Regulatory Science (TCORS
Not yet recruiting – verified December 2013

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How geography can cause allergies, and asthma, and what dairy products can … – WBTW – Myrtle Beach and Florence SC

How geography can cause allergies, and asthma, and what dairy products can …
WBTW – Myrtle Beach and Florence SC
NEW YORK CITY, NY – CBS – Where a person lives could affect their chances of having allergies and asthma. A new study shows living in places closest to the equator can put you at increased risk of developing allergy and asthma. People living near the …

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Occupational exposure to cleaning products and asthma in hospital workers.

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Occupational exposure to cleaning products and asthma in hospital workers.

Occup Environ Med. 2012 Oct 2;

Authors: Dumas O, Donnay C, Heederik DJ, Héry M, Choudat D, Kauffmann F, Le Moual N

Abstract
OBJECTIVE: Cleaning products may cause work-related asthma, but information regarding the specific exposures involved is scarce. We aimed to determine the associations between asthma and occupational exposure to cleaning agents in hospital workers. METHODS: Analyses were conducted in 179 (136 women) hospital workers and a reference population of 545 subjects (18-79 years) from the French case-control and familial Epidemiological study on the Genetics and Environment of Asthma (2003-2007). Exposures to cleaning agents were estimated using three methods: self-report, expert assessment and an asthma-specific job-exposure matrix (JEM). Associations between cleaning products and current asthma were evaluated by logistic regressions, stratified by sex and adjusted for age and smoking status. RESULTS: According to expert assessment, 55% of male and 81% of female hospital workers were exposed to cleaning/disinfecting tasks weekly (p<0.001). No association was observed between cleaning/disinfecting tasks and current asthma in men or in women whatever the assessment method used. In women, exposure to decalcifiers (expert assessment) was associated with current asthma (OR (95% CI):2.38 (1.06 to 5.33)). In hospital workers classified as exposed according to both the expert assessment and the JEM, additional associations were observed for exposure to ammonia (3.05 (1.19 to 7.82)) and to sprays with moderate/high intensity (2.87 (1.02 to 8.11)). CONCLUSIONS: Female hospital workers are often exposed to numerous cleaning products, some of which were markedly associated with current asthma. Low numbers prevented a meaningful analysis in men. Objective and more accurate estimates of occupational exposure to cleaning products are needed to better understand the adverse effects of cleaning products.

PMID: 23033509 [PubMed – as supplied by publisher]

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Chemicals in personal care products linked to childhood asthma – Zee News


Zee News

Chemicals in personal care products linked to childhood asthma
Zee News
Washington: Researchers have found that children exposed to diethyl phthalate (DEP) and butylbenzyl phthalate (BBzP)—phthalate chemicals commonly found in personal care and plastic products—have elevated risk of asthma-related airway inflammation.
Children exposed to 2 phthalates have elevated risk of asthma-related airway …Science Codex
Prenatal exposure to pesticide additive linked with childhood coughMedical Xpress

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Easing consumer concerns: Suppliers roll out new allergen-protection products – BedTimes Magazine


BedTimes Magazine

Easing consumer concerns: Suppliers roll out new allergen-protection products
BedTimes Magazine
With allergy and asthma symptoms on the rise, it's time to talk to consumers about better health, overall wellness and cleanliness in the bedroom, say suppliers of mattress and pillow protection products. GBS Enterprises offers a range of …

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