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 Daily Mail |
Could a patch containing a protein produced by dust mites EASE your asthma?
Daily Mail As well as treating existing asthma sufferers, it is hoped the new patch could also be used to prevent the disease developing in the first place in children. House dust mites, which are related to the spider family, are usually less than half a … |
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Daily Mail |
Asthma: Could a patch containing a protein produced by dust mites EASE your …
Daily Mail As well as treating existing asthma sufferers, it is hoped the new patch could also be used to prevent the disease developing in the first place in children. House dust mites, which are related to the spider family, are usually less than half a … |
View full post on asthma – Google News
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Bacterial Protein in House Dust Spurs Asthma
Highlight HEALTH A bacterial protein in common house dust may worsen allergic responses to indoor allergens, according to research conducted by the National Institutes of Health and Duke University. The finding is the first to document the presence of the protein … |
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House dust protein may worsen asthma
The Providence Journal (blog) A bacterial protein in common house dust may worsen allergic responses to indoor allergens, according to research conducted by the National Institutes of Health and Duke University. The finding is the first to document the presence of the protein … House Dust Ingredient Linked to Allergic Asthma: Study |
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Bacterial Protein in House Dust Spurs Asthma
Kansas City infoZine "Most people with asthma have allergic asthma, resulting largely from allergic responses to inhaled substances," said the paper's corresponding author Donald Cook, Ph.D., an NIEHS scientist. His research team began the study to identify environmental … |
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Bacterial Protein in House Dust Spurs Asthma According to NIH Study
eNews Park Forest Bethesda, Maryland–(ENEWSPF)–October 15, 2012. A bacterial protein in common house dust may worsen allergic responses to indoor allergens, according to research conducted by the National Institutes of Health and Duke University. The finding is the … |
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| Related Articles |
Restoration of Corticosteroid Sensitivity by p38 Mitogen Activated Protein Kinase Inhibition in Peripheral Blood Mononuclear Cells from Severe Asthma.
PLoS One. 2012;7(7):e41582
Authors: Mercado N, Hakim A, Kobayashi Y, Meah S, Usmani OS, Chung KF, Barnes PJ, Ito K
Abstract
BACKGROUND: Severe asthma accounts for a small number of asthmatics but represents a disproportionate cost to health care systems. The underlying mechanism in severe asthma remains unknown but several mechanisms are likely to be involved because of a very heterogeneous profile. We investigated the effects of a p38MAPK inhibitor in corticosteroid sensitivity in peripheral blood mononuclear cells (PBMCs) from severe asthmatics and the profile of its responders.
METHODOLOGY/PRINCIPAL FINDINGS: Corticosteroid sensitivity was determined by measuring dexamethasone inhibition of CD3/28 and TNF-? induced IL-8 production in PBMCs by using ELISA. PBMCs from severe asthmatics were relatively less sensitive to dexamethasone (Dex) as compared to those of non-severe asthmatics and healthy volunteers. The IC(50) values of Dex negatively correlated with decreased glucocorticoid receptor (GR) nuclear translocation assessed using immunocytochemistry (r?=?-0.65; p<0.0005) and with decreased FEV(1) (% predicted) (r?=?0.6; p<0.0005). A p38?/? inhibitor (SB203580) restored Dex-sensitivity in a subpopulation of severe asthma that was characterized by a defective GR nuclear translocation, clinically by lower FEV(1) and higher use of oral prednisolone. We also found that SB203580 partially inhibited GR phosphorylation at serine 226, resulting in increased GR nuclear translocation in IL-2/IL-4 treated corticosteroid insensitive U937s.
CONCLUSIONS/SIGNIFICANCE: p38MAPK?/? is involved in defective GR nuclear translocation due to phosphorylation at Ser226 and this will be a useful biomarker to identify responders to p38MAPK?/? inhibitor in the future.
PMID: 22911818 [PubMed – in process]
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 Daily Mail |
A tablet made from a protein found in house dust mites could revolutionise the …
Daily Mail The pill, which melts under the tongue, is designed to re-tune the immune system so that it does not over-react when it comes into contact with mite droppings, which are a leading trigger for asthma attacks. Early trial results show patients who take … |
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New Protein Focus of Asthma Treatment
Laboratory Equipment New information that could help in the fight against asthma has been obtained by an international collaboration of scientists utilizing the US Department of Energy's Advanced Photon Source at Argonne National Laboratory. Their results, which were … |
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Protein linked to allergic response causes airway changes in asthmatics
Sify A study conducted by researchers at Duke University has found that changes that occur in the airways of asthma patients are in part caused by the naturally occurring protein interleukin-13 (IL-13) which stimulates invasion of airway cells called … Study finds that protein IL-13 stimulates fibroblast cells to invade the … |
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