Mepolizumab reduces exacerbations in severe eosinophilic asthma [MENSA trial] – 2 Minute Medicine


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Mepolizumab reduces exacerbations in severe eosinophilic asthma [MENSA trial]
2 Minute Medicine
1. The rate of asthma exacerbations was significantly reduced in patients with severe eosphinophilic asthma receiving either intravenous or subcutaneous mepolizumab, compared to patients receiving placebo. 2. The safety profile of mepolizumab was
Seven developments in asthma researchHealio

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Vitamin D reduces the differentiation and expansion of Th17 cells in young asthmatic children.

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Vitamin D reduces the differentiation and expansion of Th17 cells in young asthmatic children.

Immunobiology. 2014 Jul 22;

Authors: Hamzaoui A, Berraïes A, Hamdi B, Kaabachi W, Ammar J, Hamzaoui K

Abstract
Vitamin D [25(OH)D3] deficiency has been associated with asthma as in many inflammatory and autoimmune pathologies; however, there is still a lack of data about the effects of administration of vitamin D in immune regulation in young asthmatic patients. In this study, we investigated its inhibitory effect on the immune response in young asthmatic patients and the possible mechanisms involved. Peripheral blood CD4(+) T cells from 10 asthmatic patients and 10 healthy controls were cultured under Th17 polarizing conditions in the presence or absence of [25(OH)D3], IL-17 cytokine production was determined by ELISA and flow cytometry. Messenger RNA (mRNA) expression of several factors related to Th17 cell function was determined by real-time PCR. The effect of [25(OH)D3]-treated dendritic cells (DCs) on CD4(+) T cell response was determined by ELISA and flow cytometry. Stimulation of naive CD4(+) T cells under Th17 polarizing conditions showed a higher Th17 cell differentiation in asthmatic patients than healthy controls. The addition of [25(OH)D3] significantly inhibited Th17 cell differentiation both in patients [P<0.001] and in normal controls [P=0.001] in a dose-dependent way. [25(OH)D3] was able to inhibit the gene expression of RORC, IL-17, IL-23R, and CCR6. [25(OH)D3]-treated DCs significantly inhibited IL-17 production [P=0.002] and decreased the percentage of CD4(+)IL-17(+) [P=0.007] in young asthmatics. The findings suggest that the inhibitory effect of [25(OH)D3] on the Th17 response was mediated via both T cells and DCs. DCs pathway is involved in the direct inhibition of 25(OH)D3 on Th17 cell differentiation in young asthmatics.

PMID: 25128460 [PubMed – as supplied by publisher]

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First-Year Allergen Exposure Reduces Asthma, Allergy Risk – Monthly Prescribing Reference


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First-Year Allergen Exposure Reduces Asthma, Allergy Risk
Monthly Prescribing Reference
Exposure to specific allergens and bacteria during the first year of life could reduce the risk of recurrent wheeze and allergic sensitization. Published in the Journal of Allergy and Clinical Immunology, 560 children at high risk for asthma were
Increased airway resistance in early childhood linked to asthmaHealio
Newborns exposed to dirt have lower allergy, asthma riskThe Guardian Nigeria

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Air Scrubber Plus Reduces Allergens and Germs That Aggravate Asthma and … – PR Web (press release)

Air Scrubber Plus Reduces Allergens and Germs That Aggravate Asthma and
PR Web (press release)
Air Scrubber Plus Reduces Allergens and Germs That Aggravate Asthma and Allergies. Air Scrubber Plus® recently announced a way to improve indoor air quality for those who suffer from asthma and allergies during Asthma and Allergy Awareness Month.

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