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LINX®, a Novel Treatment for Patients With Refractory Asthma Complicated by Gastroesophageal Reflux Disease
Medscape Background: Gastroesophageal reflux disease is one of the most common comorbidities in patients with asthma. Gastroesophageal reflux disease can be linked to difficult-to-control asthma. Current management includes gastric acid suppression therapy and … |
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Similarities and differences among eosinophilic esophagitis, proton-pump inhibitor-responsive esophageal eosinophilia, and reflux esophagitis: comparisons of clinical, endoscopic, and histopathological findings in Japanese patients.
J Gastroenterol. 2016 Apr 23;
Authors: Jiao D, Ishimura N, Maruyama R, Ishikawa N, Nagase M, Oshima N, Aimi M, Okimoto E, Mikami H, Izumi D, Okada M, Ishihara S, Kinoshita Y
Abstract
BACKGROUND: Esophageal eosinophilia is classified as either eosinophilic esophagitis (EoE) or proton-pump inhibitor-responsive esophageal eosinophilia (PPI-REE), depending on the response to PPI treatment. The aim of this study was to compare the clinical, endoscopic, and histopathological findings of EoE and PPI-REE in Japanese patients. In addition, the characteristics of these cases were compared with those of reflux esophagitis (RE) cases.
METHODS: Eleven patients diagnosed with EoE, 16 with PPI-REE, and 39 with RE, who were all consecutively examined from 2005 to 2015 at Shimane University Hospital, were enrolled. Clinical, endoscopic, and histopathological esophageal findings in these groups were retrospectively examined and compared.
RESULTS: The differences in the clinical characteristics of EoE and PPI-REE were not remarkable, though patients with EoE and PPI-REE were younger, presented a higher prevalence of allergic comorbidities, and complained of symptoms of dysphagia more frequently than those with RE. The only noteworthy differences between EoE and PPI-REE were more frequent reports of asthma (36.4 vs. 2.6 %) and food allergy (27.3 vs. 0 %) by patients with EoE (P < 0.05, P < 0.05, respectively). Endoscopic findings in patients with EoE and PPI-REE were similar, with the presence of esophageal erosions in a small percentage of PPI-REE cases being the only difference. There were no histopathological differences between EoE and PPI-REE.
CONCLUSIONS: Comparisons of clinical, endoscopic, and histopathological findings between EoE and PPI-REE showed that these two types have similar characteristics, though EoE patients showed a higher atopic background. Predicting PPI responsiveness in cases with esophageal eosinophilia is difficult and requires further investigation.
PMID: 27108416 [PubMed – as supplied by publisher]
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Our Troubles with the A Words: Asthma, Allergies and Acid Reflux
Babble To be honest as I typed the title of this post, I kinda want to call out all of the A words including the true A word. If you get my drift. It's been somewhat quiet around here with updates on Grayson because well, we've been to doctor after doctor and … |
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New Developments in Extraesophageal Reflux Disease.
Gastroenterol Hepatol (N Y). 2012 Sep;8(9):590-599
Authors: Saritas Yuksel E, Vaezi MF
Abstract
Gastroesophageal reflux disease (GERD) can present with a wide variety of extraesophageal symptoms that are usually difficult to diagnose because of the absence of typical GERD symptoms (ie, regurgitation or heartburn). The diagnostic process is further complicated by the lack of a definitive test for identifying GERD as the cause of extraesophageal reflux symptoms. Due to the low predictive value of upper endoscopy and pH testing-as well as the lack of reliability of the symptom index and symptom association probability-extraesophageal reflux disease is still an area of investigation. This paper discusses recent developments in this field, with special emphasis on new diagnostic modalities and treatment options.
PMID: 23483833 [PubMed – as supplied by publisher]
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 CBS Local |
Acid Reflux May Cause Adult Asthma
CBS Local A study in the journal “Jama Surgery” says for people with reflux, an operation to relieve their symptoms of heartburn, nausea, cough and sore throat, also relieved their symptoms of asthma-related wheezing and trouble breathing. Doctors used a new … |
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 CBS Local |
Study Shows Acid Reflux Can Cause Adult Asthma
CBS Local A study in the journal “Jama Surgery” says for people with reflux, an operation to relieve their symptoms of heartburn, nausea, cough and sore throat, also relieved their symptoms of asthma-related wheezing and trouble breathing. Doctors used a new … Study by West Penn Allegheny Surgeons Points to Reflux Disease as Cause of … |
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Nocturnal gastroesophageal reflux, asthma and symptoms of obstructive sleep apnoea: a longitudinal, general population study.
Eur Respir J. 2012 Sep 27;
Authors: Emilsson OI, Bengtsson A, Franklin KA, Torén K, Benediktsdóttir B, Farkhooy A, Weyler J, Dom S, Backer WD, Gislason T, Janson C
Abstract
Nocturnal gastroesophageal reflux (nGER) is associated with asthma and obstructive sleep apnoea (OSA). Our aim was to investigate whether nGER is a risk factor for onset of asthma and onset of respiratory and OSA symptoms in a prospective population based study.We invited 2640 subjects from Iceland, Sweden and Belgium for two evaluations over a nine years interval. They participated in structured interviews, answered questionnaires, underwent spirometries and methacholine challenge testing. nGER was defined by reported symptoms.Subjects with persistent nGER (n=123) had an independent increased risk of new asthma at follow-up [OR (95% CI): 2.3 (1.1-4.9)]. Persistent nGER was independently related to onset of respiratory symptoms [OR (95% CI): 3.0 (1.6-5.6)]. The risk of developing symptoms of OSA was increased in subjects with new and persistent nGER [OR (95% CI): 2.2 (1.3-1.6) and 2.0 (1.0-3.7), respectively]. No significant association was found between nGER and lung function or bronchial responsiveness.Persistent symptoms of nocturnal gastroesophageal reflux contributes to the development of asthma and respiratory symptoms. New onset of OSA symptoms is higher among subjects with symptoms of nGER. These findings support that nGER may play a role in the genesis of respiratory symptoms and diseases.
PMID: 23018910 [PubMed – as supplied by publisher]
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Acid reflux drugs don't help asthma in kids
Tbo.com COM | Staff A new study has found that acid reflux medicine used to treat asthma in children isn't effective. Physicians often prescribe the acid reflux drug lansoprazole in addition to standard inhaled steroid drugs to children who have asthma. |
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Acid reflux drugs don't fight asthma
GoErie.com A new study has found that acid reflux medicine used to treat asthma in children isn't effective. Physicians often prescribe the acid reflux drug lansoprazole in addition to standard inhaled steroid drugs to children who have asthma. Study finds Prevacid doesn't ease asthma UVa researcher finds common asthma treatment unbeneficial |
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Reflux drugs don't help kids' asthma
Victoria Times Colonist A new study has found that acid reflux medicine used to treat asthma in children isn't effective. Physicians often prescribe the acid reflux drug lansoprazole in addition to standard inhaled steroid drugs to children who have asthma. |
View full post on asthma – Google News