Breathe Well Live Well
Condition: Persistent Asthma
Intervention: Procedure: Bronchoscopy
Sponsors: University of Leicester; Genentech, Inc.; Queen’s University, Belfast; Medical Research Council
Not yet recruiting – verified August 2016
View full post on ClinicalTrials.gov: asthma | Studies received in the last 14 days
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LINX®, a Novel Treatment for Patients With Refractory Asthma Complicated by Gastroesophageal Reflux Disease
Medscape Background: Gastroesophageal reflux disease is one of the most common comorbidities in patients with asthma. Gastroesophageal reflux disease can be linked to difficult-to-control asthma. Current management includes gastric acid suppression therapy and … |
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Medscape |
EMA OKs Nucala for Severe Refractory Eosinophilic Asthma
Medscape The European Medicines Agency (EMA) has approved mepolizumab (Nucala, GlaxoSmithKline) as an add-on treatment for severe refractory eosinophilic asthma in adults in the 31 European countries covered by the EMA, according to a company statement. GSK gets European marketing rights for Nucala to treat asthma EU OK for GSK's novel asthma biologic Nucala Now Available for Severe Asthma |
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In refractory asthma, think vocal cord dysfunction
Family Practice News Digital Network “Vocal cord dysfunction is an important diagnosis. It's something to think about in your toughest-to-treat asthma patients. I think you'll see a lot of it,” Dr. Robert L. Keith predicted at a conference on internal medicine sponsored by the University … |
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Prevalence of severe refractory asthma smaller than estimated
Healio A smaller portion of patients with asthma fulfilled the criteria for severe refractory asthma than previously estimated, implying that severe asthma subphenotypes could meet the criteria for rare disease, according to recent research. “Prevalence … |
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Omalizumab effectively treated adults with severe refractory asthma
Healio Omalizumab was effective in treating adults with severe refractory asthma for up to 48 weeks, possibly exerting anti-inflammatory effects on small airways and reversing airway remodeling, according to recent study results. Researchers in Japan … |
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Intravenous Ketamine for Refractory Bronchospasm Precipitated by H1N1 Infection.
Front Pediatr. 2014;2:24
Authors: Agrawal A, Shrivastava J
Abstract
Acute severe bronchospasm is an emergency situation and sometimes these children may fail to respond to conventional treatment and deteriorate rapidly to respiratory failure requiring mechanical ventilation. We present a case of 2-year-old girl, who presented with severe bronchospasm resulting in respiratory failure not responding to conventional management including mechanical ventilation and was found to be H1N1 positive. She was treated with ketamine infusion, which led to prompt improvement in airway obstruction.
PMID: 24765619 [PubMed]
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US pulmonologists view refractory asthma patient treatment with biosimilar …
The Pharma Letter US pulmonologists surveyed by health care advisory firm Decision Resources estimate that only 19% percent of their severe, refractory asthma patients are treated with Genentech and Novartis' Xolair (omalizumab), the only approved drug that serves this … |
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GlaxoSmithKline initiates Phase III refractory asthma program
Equities.com The Phase III program includes two key studies: MEA115588: A 32-week multicenter, randomized, double-blind, double-dummy, placebo-controlled study in patients with severe uncontrolled refractory asthma. The primary endpoint of the study is to evaluate … Glaxo Starting Late-Stage Study of Asthma Drug GlaxoSmithKline starts final-stage tests on severe asthma drug GSK takes severe asthma antibody into phase III |
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Bronchoscopy can guide effective treatment for refractory asthma
Science Codex Using a bronchoscope to visually examine the airways and collect fluid and tissue can help guide effective therapy for difficult-to-treat asthma patients, according to researchers at National Jewish Health. Reporting in the March 2012 issue of the … |
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