Tag: relationship

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Relationship between Pesticide Metabolites, Cytokine Patterns, and Asthma-Related Outcomes in Rural Women Workers.

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Relationship between Pesticide Metabolites, Cytokine Patterns, and Asthma-Related Outcomes in Rural Women Workers.

Int J Environ Res Public Health. 2016;13(10)

Authors: Mwanga HH, Dalvie MA, Singh TS, Channa K, Jeebhay MF

Abstract
The objective of this study was to investigate the relationship between exposure to organophosphate (OP) and pyrethroid (PYR) pesticides with serum cytokine patterns and asthma-related outcomes among rural women workers. A cross-sectional study was conducted among rural women (n = 211), including those working and living on farms and nearby town dwellers. Pesticide exposure was assessed using urinary metabolite concentrations of OP and PYR pesticides. Health outcome assessment was ascertained through the European Community Respiratory Health Survey (ECRHS) questionnaire, fractional exhaled nitric oxide (FeNO), and serum cytokines associated with asthma. The prevalence of doctor-diagnosed asthma was 11%, adult-onset asthma 9%, and current asthma 6%. In this population, the proportion of T helper type 2 (Th2) cytokines (interleukin (IL)-4, IL-5, and IL-13) detectable in subjects was between 18% and 40%, while the proportion of non-Th2 cytokines (IL-6, IL-8, IL-10, IL-17, and interferon gamma) was between 35% and 71%. Most Th2 and non-Th2 cytokines were positively associated with either OP or PYR metabolites. Non-Th2 cytokines showed much stronger associations with OP metabolites (Dimethyl phosphate OR = 4.23; 95% CI: 1.54-11.65) than Th2 cytokines (Dimethyl phosphate OR = 1.69; 95% CI: 0.83-3.46). This study suggests that exposure to most OP and some PYR pesticides may be associated with asthma-related cytokines, with non-Th2 cytokines demonstrating consistently stronger relationships.

PMID: 27690066 [PubMed – as supplied by publisher]

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The Hispanic health paradox across generations: the relationship of child generational status and citizenship with health outcomes.

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The Hispanic health paradox across generations: the relationship of child generational status and citizenship with health outcomes.

Public Health. 2015 May 19;

Authors: Balcazar AJ, Grineski SE, Collins TW

Abstract
OBJECTIVES: In examining the Hispanic health paradox, researchers rarely determine if the paradox persists across immigrant generations. This study examines immigrant respiratory health disparities among Hispanic children in terms of current asthma, bronchitis, and allergies using an expanded six-group immigrant cohort framework that includes citizenship and the fourth-plus generation.
STUDY DESIGN: Cross-sectional primary survey data from 1568 caretakers of Hispanic schoolchildren in El Paso, Texas (USA), were utilized.
METHODS: Data were analyzed using generalized linear models.
RESULTS: Results indicate that a healthy immigrant advantage lasts until the 2.5 generation for bronchitis and allergies (P < 0.05), and until the third generation for asthma (P < 0.10). Citizenship was not an influence on the likelihood of a child having a respiratory health condition.
CONCLUSIONS: Findings demonstrate the utility of the expanded six-group cohort framework for examining intergenerational patterns in health conditions among immigrant groups.

PMID: 26002345 [PubMed – as supplied by publisher]

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UC Researchers examine relationship between asthma and mental health – The News Record


The News Record

UC Researchers examine relationship between asthma and mental health
The News Record
The Health and Anxiety Psychopathology Laboratory at the University of Cincinnati, which studies the connections between mental and physical health, is conducting ongoing research focused on individuals with asthma and how anxiety or depression can …

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The relationship between antibiotic therapy in early childhood and the symptoms of allergy in children aged 6-8 years – the questionnaire study results.

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The relationship between antibiotic therapy in early childhood and the symptoms of allergy in children aged 6-8 years – the questionnaire study results.

Int J Occup Med Environ Health. 2012 Dec 3;

Authors: Raciborski F, Tomaszewska A, Komorowski J, Samel-Kowalik P, Bia?oszewski AZ, Artur W, Lusawa A, Szyma?ski J, Opoczy?ska D, Dru?ba M, Borowicz J, Lipiec A, Kapalczynski WJ, Samoli?ski B

Abstract
INTRODUCTION: Studies based on the ISAAC questionnaire suggest a correlation between the use of antibiotics and the prevalence of asthma and allergy in children aged 6-7 years. The number of courses of antibiotic therapy is an important factor. OBJECTIVES: To investigate the relationship between the use of antibiotics during the first years of life and the prevalence of allergy and asthma among children (aged 6-8 years) in the urban population of Poland. MATERIALS AND METHODS: A survey-based study with a self-completed questionnaire. The respondents were parents of children aged 6-8 years living in Warszawa, Poland. 1461 completed questionnaires were collected. RESULTS: Asthma was declared in 4.3% of the children. Wheezing and/or sibilant rhonchi within 12 months before the study was observed in 13.5% of the cases. Asthma medication was taken by 21.8% of the children. Allergic rhinitis was declared in 18.7% of the children. Problems with sneezing, rhinorrhea, and nasal congestion not associated with cold or fever were observed in 40.7% of the children. The analysis of the odds ratios between the use of antibiotics and the symptoms of allergic diseases revealed a clear correlation. The highest odds ratio was observed between the completion of over three courses of antibiotic therapy prior to the age of 12 months and the declaration of one of the following: asthma (OR = 5.59, 95% CI: 2.6-12.01), wheezing and/or sibilant rhonchi (OR = 4.68, 95% CI: 3.01-7.27) and taking medicines for breathlessness (OR = 5.12, 95% CI: 3.42-7.68). CONCLUSIONS: There is a direct relationship between antibiotic use in the first 3 years of life and asthma and allergy symptoms in children aged 6-8 years old.

PMID: 23212289 [PubMed – as supplied by publisher]

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Updates in the relationship between human rhinovirus and asthma.

Updates in the relationship between human rhinovirus and asthma.

Allergy Asthma Immunol Res. 2012 May;4(3):116-21

Authors: Kim WK, Gern JE

Abstract
Human rhinovirus (HRV) is a nonenveloped, single stranded RNA virus belonging to the family Picornaviridae. HRV infections can cause both upper and lower respiratory illnesses in children and adults. Lower respiratory illnesses are more likely to occur in specific high risk groups, including infants, and children and adults with asthma. The relationships between rates of infection and the risk of clinical illness and exacerbation are not completely understood. Recent studies employing polymerase chain reaction and other molecular techniques indicate that there are new branches on the HRV family tree, and one characteristic of recently detected viruses is that they cannot be detected by standard tissue culture. Here we review the current literature and discuss new advances in understanding the link between HRV and asthma.

PMID: 22548203 [PubMed – in process]

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Antibiotics and Asthma, an Adverse Relationship? – dailyRx

Antibiotics and Asthma, an Adverse Relationship?
dailyRx
The rise of childhood asthma may be linked to antibiotic use. A new study focused on how antibiotics may prevent healthy immune system development leading to new cases of asthma. Two commonly used antibiotics that are used to treat intestinal …
Antibiotic treatment increases the severity of asthma in young miceScience Daily (press release)

all 2 news articles »

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Relationship between air pollution, NFE2L2 gene polymorphisms and childhood asthma in a Hungarian population.

Relationship between air pollution, NFE2L2 gene polymorphisms and childhood asthma in a Hungarian population.

J Community Genet. 2011 Dec 30;

Authors: Ungvári I, Hadadi E, Virág V, Nagy A, Kiss A, Kalmár A, Zsigmond G, Semsei AF, Falus A, Szalai C

Abstract
Air pollution and subsequent increased oxidative stress have long been recognized as contributing factors for asthma phenotypes. Individual susceptibility to oxidative stress is determined by genetic variations of the antioxidant defence system. In this study, we analysed the association between environmental nitrogen dioxide (NO(2)) exposure and single nucleotide polymorphisms (SNP) in NFE2L2 and KEAP1 genes and their common impact on asthma risk. We genotyped 12 SNPs in a case-control study of 307 patients diagnosed with asthma and 344 controls. NO(2) concentration was collected from the period preceding the development of asthma symptoms. Multiple logistic regression was applied to evaluate the effects of the studied genetic variations on asthma outcomes in interaction with NO(2) exposure. Our data showed that genotypes of rs2588882 and rs6721961 in the regulatory regions of the NFE2L2 gene were inversely associated with infection-induced asthma (odds ratio (OR)?=?0.290, p?=?0.0015, and OR?=?0.437, p?=?0.007, respectively). Furthermore, case-only analyses revealed significant differences for these SNPs between asthma patients that lived in modestly or highly polluted environment (OR?=?0.43 (0.23-0.82), p?=?0.01, and OR?=?0.51, p?=?0.02, respectively, in a dominant model). In conclusion, our results throw some new light upon the impact of NFE2L2 polymorphisms on infection-induced asthma risk and their effect in gene-environment interactions.

PMID: 22207565 [PubMed – as supplied by publisher]

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