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Coast Guard outlines Osprey case response
Gloucester Daily Times Crew members on board the herring trawler Osprey first contacted the Coast Guard regarding what appeared to be a “severe asthma attack” that caused Michael Grindle to collapse Sunday at around 3:45 a.m. The Coast Guard notified the Osprey's crew that … Gloucester trawler crew member from Maine dies at sea Body taken from herring trawler |
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Hay Fever and Asthma as Markers of Atopic Immune Response and Risk of Colorectal Cancer in Three Large Cohort Studies.
Cancer Epidemiol Biomarkers Prev. 2013 Mar 19;
Authors: Jacobs EJ, Gapstur SM, Newton CC, Turner MC, Campbell PT
Abstract
BACKGROUND: In a previous analysis of 12 cancers in the Cancer Prevention Study II (CPS-II) cohort including follow-up from 1982-2000, having both hay fever and asthma was associated with lower colorectal cancer mortality. The combination of these allergic conditions may be a marker for allergy-related immune responses that could inhibit colorectal carcinogenesis.METHODS: We examined the association of having both hay fever and asthma with colorectal cancer mortality among 1,023,191 participants in CPS-I, followed from 1959-1972, and 1,102,092 participants in CPS-II, now followed from 1982-2008. We also examined associations with colorectal cancer incidence among 174,917 participants in the CPS-II Nutrition Cohort, a subgroup of CPS-II followed from 1992-2007. During the follow-up, there were 5,644 colorectal cancer deaths in CPS-I, 13,558 colorectal cancer deaths in CPS-II, and 3,365 incident colorectal cancer cases in the CPS-II Nutrition Cohort. Cox proportional hazards regression was used to calculate multivariable-adjusted relative risks (RR) and 95% confidence intervals (CI).RESULTS: RRs for colorectal cancer mortality associated with having both asthma and hay fever, compared with neither condition, were 0.90 (95% CI, 0.74-1.09) in CPS-I, 0.79 (95% CI, 0.69-0.91) in CPS-II, and 0.83 (95% CI, 0.74-0.92) when results from both cohorts were combined in a meta-analysis. The corresponding RR for colorectal cancer incidence in the CPS-II Nutrition Cohort was 0.90 (95% CI, 0.71-1.14).CONCLUSION: These results support an association between having both hay fever and asthma and modestly lower colorectal cancer mortality.Impact: Research examining other potential markers of allergy-related immune response in relation to colorectal cancer is warranted. Cancer Epidemiol Biomarkers Prev; 22(4); 1-9. ©2013 AACR.
PMID: 23513040 [PubMed – as supplied by publisher]
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TX Department to Investigate Response to Asthma Patient
FireEngineering.com He was having an asthma attack and couldn't breathe, according to FOX 4. A fire truck arrived within six minutes of the call, and paramedics arrived three minutes later. However, when they arrived, Gray's wife, Eboni, said there was no sense of urgency. Dallas Fire Rescue investigates handling of asthma attack patient |
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RGS5 gene and therapeutic response to short acting bronchodilators in paediatric asthma patients.
Pediatr Pulmonol. 2012 Nov 28;
Authors: Labuda M, Laberge S, Brière J, Bérubé D, Krajinovic M
Abstract
Short-acting ?2-adrenergic receptor agonists are commonly used bronchodilators for symptom relief in asthmatics. Recent evidence demonstrated that prolonged exposure of cultured airway smooth muscle cells to ?2 agonists directly augments procontractile signaling pathways with the change in expression of regulator of G protein signaling 5 (RGS5). The aim of this study was to test whether genetic variants in RGS5 gene affect the response to short acting ?2-agonists. Bronchodilator responsiveness was assessed in 137 asthmatic children by % change in baseline forced expiratory volume in 1?sec (FEV(1) ) after administration of albuterol. The analyses were performed in patients with FEV(1) /FVC ratio below 0.9 (FVC-forced vital capacity, n?=?99). FEV(1) % change adjusted for baseline FEV(1) values was significantly different between genotypes of rs10917696 C/T polymorphism (P?=?0.008). The association remained significant with inclusion of age, sex, atopy, parental smoking, and controller medications into multivariate model (P?=?0.005). We also identified additive effect on the treatment outcome with previously published genetic variant G/A rs1544791 in phosphodiesterase 4 (PDE4D) gene. Carriers of two risk alleles (C and G) had adjusted mean % FEV(1) change value 4.6?±?1.3, while carriers of one and none of the risk alleles had 8.1?±?0.7% and 13.5?±?2.4%, respectively, P?=?0.001. Our work identifies a new genetic variant in RGS5 demonstrating additive effect with PDE4D, both implicated in modulation of asthma treatment. Pediatr Pulmonol. © 2012 Wiley Periodicals, Inc.
PMID: 23193110 [PubMed – as supplied by publisher]
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Southfield to probe 911 response after boy, 10, dies of asthma attack
Detroit Free Press Fire Chief Keith Rowley said a large house fire that swamped the department's resources led to a 15-minute response time to the Oxley Street apartment of Xavier Joe, who was having an asthma attack. Rowley said the department prides itself on keeping … Southfield officials reviewing asthma attack response time 10-year-old Southfield boy dies from asthma attack, EMS response time blamed |
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CBS Local |
Southfield officials reviewing asthma attack response time
The Detroit News Southfield — City officials have reached out to the family of a 10-year-old boy who died after an asthma attack on Sunday. They are also probing claims by the mother of Xavier Joe that it took paramedics more than a half-hour to arrive after she … Mother says EMS took too long |
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 MD News |
Asthma treatment response reduced in obese patients
Clinical Advisor Higher levels of neutrophilic inflammation may explain why obese patients with asthma respond less to corticosteroid treatment. Obese asthma patients have reduced treatment response |
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Obese asthma patients have reduced treatment response
Medical Xpress (HealthDay) — Compared with lean patients, obese patients with asthma have higher neutrophil counts and a reduced response to corticosteroid treatment, … |
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MD News (press release) |
Obese Asthma Patients Have Reduced Treatment Response
MD News (press release) Compared with lean patients, obese patients with asthma have higher neutrophil counts and a reduced response to corticosteroid treatment. |
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AAAAI: Corticosteroid Response in Asthma Impacted by BMI
Doctors Lounge For children with asthma, an increased body mass index is associated with a decreased response to corticosteroids and increased daily requirements for inhaled corticosteroids, according to a study presented at the annual meeting of the American Academy … |
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