Breathe Well Live Well
Conditions: Allergy; Asthma; Rhinitis
Interventions: Drug: Mitizax; Drug: Placebo
Sponsors: Abbott; Linical Co., Ltd; Datamap
Recruiting – verified November 2015
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Allergy immunotherapy prevents asthma in patients with allergic rhinitis
Healio “Allergy immunotherapy effectively prevents the progression of allergic rhinitis to asthma in a real-life setting. This asthma-preventive effect is strongest in products containing native allergens,” Jochen Schmitt, MD, MPH, of the Center for Evidence … |
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Genetic Ancestry and Asthma and Rhinitis Occurrence in Hispanic Children: Findings from the Southern California Children’s Health Study.
PLoS One. 2015;10(8):e0135384
Authors: Salam MT, Avoundjian T, Knight WM, Gilliland FD
Abstract
BACKGROUND: Asthma and rhinitis are common childhood health conditions. Being an understudied and rapidly growing population in the US, Hispanic children have a varying risk for these conditions that may result from sociocultural (including acculturative factors), exposure and genetic diversities. Hispanic populations have varying contributions from European, Amerindian and African ancestries. While previous literature separately reported associations between genetic ancestry and acculturation factors with asthma, whether Amerindian ancestry and acculturative factors have independent associations with development of early-life asthma and rhinitis in Hispanic children remains unknown. We hypothesized that genetic ancestry is an important determinant of early-life asthma and rhinitis occurrence in Hispanic children independent of sociodemographic, acculturation and environmental factors.
METHODS: Subjects were Hispanic children (5-7 years) who participated in the southern California Children’s Health Study. Data from birth certificates and questionnaire provided information on acculturation, sociodemographic and environmental factors. Genetic ancestries (Amerindian, European, African and Asian) were estimated based on 233 ancestry informative markers. Asthma was defined by parental report of doctor-diagnosed asthma. Rhinitis was defined by parental report of a history of chronic sneezing or runny or blocked nose without a cold or flu. Sample sizes were 1,719 and 1,788 for investigating the role of genetic ancestry on asthma and rhinitis, respectively.
RESULTS: Children had major contributions from Amerindian and European ancestries. After accounting for potential confounders, per 25% increase in Amerindian ancestry was associated with 17.6% (95% confidence interval [CI]: 0.74-0.99) and 13.6% (95% CI: 0.79-0.98) lower odds of asthma and rhinitis, respectively. Acculturation was not associated with either outcome.
CONCLUSIONS: Earlier work documented that Hispanic children with significant contribution from African ancestry are at increased asthma risk; however, in Hispanic children who have little contribution from African ancestry, Amerindian ancestry was independently associated with lower odds for development of early-childhood asthma and rhinitis.
PMID: 26263549 [PubMed – in process]
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Oneindia |
11% Delhiites suffer from asthma, rhinitis: Nadda
Times of India "As per a survey conducted by Vallabbhai Patel Chest Institute Delhi in 2006, which covered 5,900 adults belonging to urban, rural and slum population in Delhi, 11.69% were found to be suffering from rhinitis and 11.03% from asthma," Health Minister J … 11 per cent Delhiites suffering from Asthma: Govt |
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Condition: Allergic Rhinitis
Interventions: Drug: Levocetirizine; Drug: Desloratadine
Sponsor: Iuliu Hatieganu University of Medicine and Pharmacy
Completed – verified July 2015
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Montelukast: A Review of Recent Studies in Pediatric Asthma and Allergic Rhinitis
Medscape Montelukast was approved by the Food and Drug Administration (FDA) on February 20, 1998 for the treatment of asthma in children and adults. It has gained widespread acceptance as an adjunct to inhaled corticosteroids and beta-adrenergic agonists in the … |
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Later onset of menarche reduces risk for allergic rhinitis, asthma
Healio “Based on the present results, there seemed to be an inverse dose-response relationship between age at menarche and incidence of asthma, with earlier menarche being associated with a higher risk of developing asthma after puberty,” Junxiang Wei, MSc, … |
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Related Articles |
Hormonal factors and incident asthma and allergic rhinitis during puberty in girls.
Ann Allergy Asthma Immunol. 2015 May 21;
Authors: Wei J, Gerlich J, Genuneit J, Nowak D, Vogelberg C, von Mutius E, Radon K
Abstract
BACKGROUND: Accumulating evidence is indicating that hormonal factors play a role in new-onset allergic rhinitis and asthma after puberty.
OBJECTIVE: To determine whether age at menarche and use of hormonal contraceptives predict new-onset allergic rhinitis and asthma after puberty in young German women.
METHODS: A prospective community-based cohort study followed 1,191 girls 9 to 11 years old to early adulthood (19-24 years old). Self-administrated questionnaires concerning age at menarche, use of hormonal contraceptives, and status and age at onset of physician-diagnosed allergic rhinitis and asthma were collected at 16 to 18 and 19 to 24 years of age. Logistic regression models were used to analyze the incidence of asthma and allergic rhinitis after puberty and pooled estimates were obtained from the final model.
RESULTS: Eleven percent of girls developed allergic rhinitis after menarche and 3% reported new-onset asthma. Late menarche (>13 years of age) was statistically significantly inversely related to allergic rhinitis (adjusted odds ratio [OR] 0.32, 95% confidence interval [CI] 0.14-0.74) but did not reach the level of statistical significance for asthma (OR 0.32, 95% CI 0.07-1.42). Use of hormonal contraceptives was inversely associated with new-onset allergic rhinitis (OR 0.14, 95% CI 0.08-0.23) and asthma (OR 0.27, 95% CI 0.12-0.58) after puberty.
CONCLUSION: This study shows that girls with late onset of menarche are less likely to develop allergic rhinitis after puberty compared with those who have menarche at an average age. These findings also suggest that, in addition to endogenous hormones, hormonal contraceptives play a role and might protect young women from allergies and asthma.
PMID: 26003905 [PubMed – as supplied by publisher]
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Allergic rhinitis without asthma and chronic bronchitis
Medscape Conclusions The impact of asthma, chronic bronchitis and allergic rhinitis on all-cause hospitalizations and limitations in daily activities is substantial, and it is markedly different among adults from the general population in Italy. The … |
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Related Articles |
The association between asthma and rhinitis is stable over time despite diverging trends in prevalence.
Respir Med. 2015 Jan 21;
Authors: Bjerg A, Eriksson J, Ólafsdóttir IS, Middelveld R, Franklin K, Forsberg B, Larsson K, Torén K, Dahlén SE, Janson C
Abstract
BACKGROUND: Despite the well-known association between asthma and rhinitis, in Swedish adults the prevalence of rhinitis rose from 22% to 31% between 1990 and 2008 while asthma prevalence was unchanged. We tested whether the association of rhinitis with asthma was stable over time using the same population-based databases.
METHODS: Two surveys of adults (20-44 years) living in three regions of Sweden, carried out in 1990 (n = 8982) and 2008 (n = 9156) were compared. Identical questions regarding respiratory symptoms, asthma and rhinitis were used. Asthmatic wheeze: Wheeze with breathlessness apart from colds. Current asthma: Asthma attacks and/or asthma medication use.
RESULTS: Subjects with rhinitis had level time trends in asthmatic wheeze, current asthma and most nocturnal respiratory symptoms between 1990 and 2008, adjusted for age, sex, area and smoking. Any wheeze however decreased slightly. In never-smokers asthma symptoms were similarly associated with rhinitis in 1990 and 2008: any wheeze OR 4.0 vs. 4.4 (p = 0.339); asthmatic wheeze OR 6.0 vs. 5.9 (p = 0.937); and current asthma OR 9.6 vs. 7.7 (p = 0.213). In the whole population there were decreases in the asthma symptoms most closely associated to smoking, which decreased by half 1990-2008. Conversely current asthma, which was strongly associated with rhinitis and not with smoking, increased (p < 0.001).
CONCLUSIONS: The association of rhinitis with asthma was stable between 1990 and 2008. The pattern in the time trends of asthma outcomes strongly suggests that decreased smoking counterbalanced the driving effect of increased rhinitis on asthma prevalence. The findings illustrate the public health benefits of decreased smoking.
PMID: 25638411 [PubMed – as supplied by publisher]
View full post on pubmed: asthma