Study from Health Department, Montefiore Medical Center targets rodents, pests … – New York Daily News


New York Daily News

Study from Health Department, Montefiore Medical Center targets rodents, pests
New York Daily News
Asthma relief might be as simple as ridding the house of roaches and mice. Researchers from the city Health Department and Montefiore Medical Center are recruiting low-income Bronx children with the respiratory ailment for a new study to test if pest

and more »

View full post on asthma – Google News

Suffering from Allergies or Asthma Attacks? Pests and Rodents Could Be the … – EON: Enhanced Online News (press release)

Suffering from Allergies or Asthma Attacks? Pests and Rodents Could Be the
EON: Enhanced Online News (press release)
READING, Pa.–(BUSINESS WIRE)–It's May. Unfortunately, along with our love of spring can come a resurgence of allergies and asthma attacks. Just don't blame it all on the pollen. It could be the pests. May is National Asthma and Allergy Awareness

and more »

View full post on asthma – Google News

Suffering from Allergies or Asthma Attacks? Pests and Rodents Could Be the … – MarketWatch (press release)

Suffering from Allergies or Asthma Attacks? Pests and Rodents Could Be the
MarketWatch (press release)
READING, Pa., May 16, 2013 (BUSINESS WIRE) — It's May. Unfortunately, along with our love of spring can come a resurgence of allergies and asthma attacks. Just don't blame it all on the pollen. It could be the pests. May is National Asthma and Allergy

and more »

View full post on asthma – Google News

Suffering from Allergies or Asthma Attacks? Pests and Rodents Could Be the … – Fort Mills Times


Fort Mills Times

Suffering from Allergies or Asthma Attacks? Pests and Rodents Could Be the
Fort Mills Times
It's May. Unfortunately, along with our love of spring can come a resurgence of allergies and asthma attacks. Just don't blame it all on the pollen. It could be the pests. May is National Asthma and Allergy Awareness Month, and with it comes a little

and more »

View full post on asthma – Google News

Sphingosine-1-phosphate induced airway hyperreactivity in rodents is mediated by the S1P3 receptor.

Sphingosine-1-phosphate induced airway hyperreactivity in rodents is mediated by the S1P3 receptor.

J Pharmacol Exp Ther. 2012 May 8;

Authors: Trifilieff A, Fozard JR

Abstract
There is a need to better understand the mechanism of airway hyperreactivity, a key feature of asthma. Evidence suggests that sphingosine-1-phosphate (S1P) could be a major player in this phenomenon. The purpose of this work was to define the S1P receptor responsible for this phenomenon. We have studied, in the rat, the effect of two S1P synthetic receptor ligands, FTY720 (which in its phosphorylated form is a potent agonist at each S1P receptor except S1P2) and AUY954 (a highly selective S1P1 agonist) on lung function in vivo. This was complemented by in vitro studies using isolated trachea from the rat, the S1P3 receptor-deficient mouse and its wild type counterpart. Following oral administration, FTY720 induced a generalized airway hyperreactivity to a range of contractile stimuli. This was observed as early as one hour post dosing, lasted for at least 24 hours and was not subject to desensitization. In both the rat and wild type mouse isolated trachea, pre-incubation with the active phosphorylated metabolite of FTY720, induced hyperresponsiveness to 5-HT. This effect was not seen in the isolated tracheas from S1P3 receptor-deficient mice. AUY954, did not mimic the effect of FTY720 either in vivo or in vitro. Our data are consistent with activation of the S1P pathway inducing a generalized airway hyperreactivity in rats and mice that is mediated by the S1P3 receptor. S1P3 receptor antagonists might prove useful as new therapeutic strategies aimed at blocking the airway hyperreactivity observed in asthma.

PMID: 22570366 [PubMed – as supplied by publisher]

View full post on pubmed: asthma