Tag: Salbutamol

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Brentford star Alan Judge reprimanded after being found with too much asthma-treating drug Salbutamol in his system – getwestlondon


getwestlondon

Brentford star Alan Judge reprimanded after being found with too much asthma-treating drug Salbutamol in his system
getwestlondon
The Irishman, who has suffered from exercise-induced asthma since he was a child, was deemed to have too much Salbutamol, a common drug used for treating the condition via an inhaler, in his system. Judge has permission by the authorities to use it.
Alan Judge: Brentford midfielder given doping warningBBC Sport
Alan Judge warned for breaching anti-doping regulationsITV News

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High-Dose Inhaled Salbutamol Does Not Improve 10-km Cycling Time-Trial Performance.

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High-Dose Inhaled Salbutamol Does Not Improve 10-km Cycling Time-Trial Performance.

Med Sci Sports Exerc. 2015 Apr 8;

Authors: Koch S, Ahn JR, Koehle MS

Abstract
BACKGROUND: ?2-agonists are on the World Anti-Doping Agency’s (WADA) list of prohibited substances; however, athletes are allowed to treat symptoms of exercise-induced bronchoconstriction with a maximal daily dose of 1600 ?g of salbutamol when taken up by inhalation.
PURPOSE: To investigate if 1600 ?g of salbutamol lead to an enhanced time-trial performance in trained, competitive male cyclists, with and without exercise-induced bronchoconstriction, based on inhaled dose per kilogram of body weight (kg/BW).
METHODS: In a randomized, crossover design, 20 trained male cyclists (8 with a positive eucapnic voluntary hyperpnea challenge (EVH+) and 12 with a negative EVH challenge (EVH-) performed two simulated 10-km time-trials on a cycle ergometer 30-min after the inhalation of either 1600 ?g of salbutamol or placebo. Lung function, assessed by forced expiratory volume in 1 second (FEV1), was measured immediately before and 15 min after inhalation. The main performance outcome was mean power output.
RESULTS: After the inhalation of salbutamol, FEV1 was significantly increased by 6.4% (4.9%) vs. 1.0% (4.4%) with placebo (p < 0.001). Despite this increase in FEV1, mean power output during the salbutamol time-trial was not increased, regardless of relative dose per kg/BW and asthma status. Mean heart rate (p = 0.01), respiratory rate (p = 0.01) and minute ventilation (p = 0.03) and perceived leg discomfort (p = 0.03) were significantly increased in the salbutamol condition.
CONCLUSIONS: The inhalation of 1600?g salbutamol improved FEV1 regardless of EVH-status, but did not improve 10-km time-trial performance in trained, competitive male cyclists, regardless of relative dose per kg/BW or EVH-status. Significant increases in heart rate and minute ventilation occurred secondary to stimulation of the adrenergic nervous system.

PMID: 25856682 [PubMed – as supplied by publisher]

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Anti-inflammatory and antinociceptive effects of salbutamol on acute and chronic models of inflammation in rats: involvement of an antioxidant mechanism.

Anti-inflammatory and antinociceptive effects of salbutamol on acute and chronic models of inflammation in rats: involvement of an antioxidant mechanism.

Mediators Inflamm. 2012;2012:438912

Authors: Uzkeser H, Cadirci E, Halici Z, Odabasoglu F, Polat B, Yuksel TN, Ozaltin S, Atalay F

Abstract
The possible role of ?-2 adrenergic receptors in modulation of inflammatory and nociceptive conditions suggests that the ?-2 adrenergic receptor agonist, salbutamol, may have beneficial anti-inflammatory and analgesic effects. Therefore, in this study, we induced inflammatory and nociceptive responses with carrageenan-induced paw edema or cotton-pellet-induced granuloma models, both of which result in oxidative stress. We hypothesized that salbutamol would prevent inflammatory and nociceptive responses by stimulating ?-2 adrenergic receptors and the prevention of generation of ROS during the acute inflammation process in rats. Both doses of salbutamol used in the study (1 and 2?mg/kg) effectively blocked the acute inflammation and inflammatory nociception induced by carrageenan. In the cotton-pellet-induced granuloma test, both doses of salbutamol also significantly decreased the weight of granuloma tissue on the cotton pellets when compared to the control. Anti-inflammatory and analgesic effects of salbutamol were found to be comparable with those of indomethacin. Salbutamol decreased myeloperoxidase (MPO) activity and lipid peroxidation (LPO) level and increased the activity of superoxide dismutase (SOD) and level of glutathione (GSH) during the acute phase of inflammation. In conclusion, salbutamol can decrease acute and chronic inflammation, possibly through the stimulation of ?-2 adrenergic receptors. This anti-inflammatory effect may be of significance in asthma treatment, where inflammation also takes part in the etiopathology. This study reveals that salbutamol has significant antioxidative effects, which at least partially explain its anti-inflammatory capabilities. These findings presented here may also shed light on the roles of ?-2 adrenergic receptors in inflammatory and hyperalgesic conditions.

PMID: 22665951 [PubMed – in process]

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Albuterol (Salbutamol) Found In Paris Hilton Purse During Arrest – Health Related Infos (blog)


msnbc.com

Albuterol (Salbutamol) Found In Paris Hilton Purse During Arrest
Health Related Infos (blog)
It is often used to treat acute asthma, and also provides protection against exercise-induced asthma. While the substance is not used as any sort of …
Paris Hilton charged with felony, denies purse was hers, according to policeEntertainment Weekly
What's Albuterol? A Prescription Medication Found with Paris HiltonHULIQ
Albuterol Found Along with Cocaine on Paris HiltonThe News of Today
Execte News –New York Daily News –The Associated Press
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