Autoimmune disease preceding amyotrophic lateral sclerosis: An epidemiologic study.
Neurology. 2013 Aug 14;
Authors: Turner MR, Goldacre R, Ramagopalan S, Talbot K, Goldacre MJ
OBJECTIVE: To study whether the risk of amyotrophic lateral sclerosis (ALS) is increased in people with prior autoimmune disease.
METHODS: An all-England hospital record-linkage dataset spanning 1999-2011 was used. Cohorts were constructed of people with each of a range of autoimmune diseases; the incidence of ALS in each disease cohort was compared with the incidence of ALS in a cohort of individuals without prior admission for the autoimmune disease.
RESULTS: There were significantly more cases than expected of ALS associated with a prior diagnosis of asthma, celiac disease, younger-onset diabetes (younger than 30 years), multiple sclerosis, myasthenia gravis, myxedema, polymyositis, Sjögren syndrome, systemic lupus erythematosus, and ulcerative colitis.
CONCLUSIONS: Autoimmune disease associations with ALS raise the possibility of shared genetic or environmental risk factors.
PMID: 23946298 [PubMed – as supplied by publisher]
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