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Clinical usefulness of mepolizumab in severe eosinophilic asthma
Dove Medical Press Abstract: Asthma is a chronic inflammatory disorder of the airways with variable clinical severity from very mild and occasional symptoms to recurrent critical exacerbations, at risk of fatal or near-fatal outcome, in a small percentage of patients … |
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Manchester Evening News |
Mum says son who died after severe asthma attack will live on through others after his organs were donated
Manchester Evening News The mum of a teenage boy who died after suffering a severe asthma attack says her son will live on through others after his organs were donated. Thomas-Michael Martin, known as Tom, was on his way to hospital with mum Dawn Gerrard and a friend when … |
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Lung Disease News |
Severe Asthma Reduced in Phase 3 Benralizumab Tests
Lung Disease News AstraZeneca recently announced that the new severe asthma medicine benralizumab met the primary endpoints in two Phase 3 registration trials. Findings of the trials called SIROCCO and CALIMA, revealed that the monoclonal antibody compound was well … |
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Penrose youth on a miraculous recovery after severe asthma attack
Canon City Daily Record Hank also suffers from severe asthma, so his lungs couldn't fight off the bacteria. Unable to breathe on his own, Hank was airlifted from Penrose to Colorado Springs, where he was placed in the intensive care unit and incubated with a ventilator tube. |
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| Related Articles |
Hypoxic Challenge Testing for Fitness to Fly with Severe Asthma.
Aerosp Med Hum Perform. 2016;87(6):571-574
Authors: George PM, Orton C, Ward S, Menzies-Gow A, Hull JH
Abstract
INTRODUCTION: Commercial airline travel poses a recognized risk to patients with respiratory disease, including in those with asthma. Hypoxic challenge testing (HCT) is typically employed to mitigate this risk by dictating in-flight oxygen requirement.
METHODS: The role of HCT has not been formally studied in patients with severe asthma and we therefore evaluated HCT assessment in a cohort of patients with severe asthma (N = 37).
RESULTS: Over half (57%) of patients had a positive HCT. Baseline oxygen saturation (Spo2) was poorly predictive of a recommendation for supplementary oxygen in flight; two-thirds of those deemed to require oxygen had a baseline Spo2 > 95%. A combination of any two of: Pao2 ? 10.5 kPa, FEV1 ? 60% predicted, and PEF ? 350 L · min(-1) predicted the need for in-flight oxygen with a sensitivity of 89% and a specificity of 69%. Furthermore, no patient with an Spo2 > 95% and FEV1 > 85% predicted had a positive HCT.
CONCLUSION: Overall, the findings indicate that HCT should be considered for all patients with severe asthma, regardless of resting oxygen saturation level. George PM, Orton C, Ward S, Menzies-Gow A, Hull JH. Hypoxic challenge testing for fitness to fly with severe asthma. Aerosp Med Hum Perform. 2016; 87(6):571-574.
PMID: 27208681 [PubMed – as supplied by publisher]
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Wall Street Journal |
AstraZeneca's Severe Asthma Drug Positive in Phase III
Zacks.com These randomized, double-blind, parallel-group, placebo-controlled studies evaluated the safety and efficacy of benralizumab as an add-on therapy in the treatment of severe uncontrolled asthma with eosinophilic inflammation in patients aged 12 years … AstraZeneca's Asthma Drug Shows Positive Results AstraZeneca set to go head to head against GSK with asthma drug AstraZeneca asthma drug hits goal, to enter competitive market |
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Mother of children with severe persistent asthma plans 'I Love Lungs' walk
WECT-TV6 Our Lauren Rautenkranz is the emcee of the event and she will deliver a special asthma forecast as she kicks off the walk. The event is planned by Laura Kellogg, RN, AE-C. Kellogg and her family were invited to the White House last year as President … |
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Medscape |
Severe Childhood Asthma Linked to COPD Risk Later
WebMD THURSDAY, May 12, 2016 (HealthDay News) — Though many children with persistent asthma get better as they get older, some may go on to develop chronic obstructive pulmonary disease (COPD) in early adulthood, a new study suggests. People with the … Persistent Childhood Asthma Linked to Early COPD Persistent childhood asthma linked to COPD Beware! Severe asthma in childhood can cause lung disease |
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KMTV |
Treating Severe Asthma 5/11/16
KMTV For those who suffer from asthma, controlling the disease becomes a critical part of its management and, in some cases, everyday life. However, few understand the daily struggle of managing the condition because of the nature of the disease itself … |
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Extreme heat, precipitation linked to more severe asthma requiring hospitalization
Science Daily Based on over a decade of asthma hospitalization data (115,923 cases from 2000-2012), researchers observed higher risk of asthma hospitalization after extreme heat or extreme precipitation events. The increases in risk were particularly high during … |
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