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 Zee News |
`Asthmatic kids may suffer severe anxiety`
Zee News University of Western Australia (UWA) psychologist and study co-author Monique Robinson said their findings build on previous studies which have found that as the severity of asthma increases, so do problems such as anxiety and depression. "We were … Asthmatic kids likelier to be depressed and anxious Asthma 'Causes' Mental Health Problems Among Children |
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Boston Scientific's Device To Relieve Severe Asthma: A Major Opportunity
Seeking Alpha Earlier in 2012 Boston Scientific's incoming CEO Michael Mahoney said about the Alair asthma treatment that it will be marketed in 20 countries and 200 sites by the end of the 2012. Mahoney predicted that the worldwide market for bronchial thermoplasty … |
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 IBTimes.co.uk |
Asthmatic kids may suffer severe anxiety
Times of India University of Western Australia (UWA) psychologist and study co-author Monique Robinson said their findings build on previous studies which have found that as the severity of asthma increases, so do problems such as anxiety and depression. "We were … Asthma 'Causes' Mental Health Problems Among Children |
View full post on asthma – Google News
IBTimes.co.uk |
'Asthmatic kids may suffer severe anxiety'
Newstrack India Sydney, Sep 17 (IANS) Young children with severe or persistent asthma are more likely to develop many common mental health problems like anxiety and depression, an Australian study says. University of Western Australia (UWA) psychologist and study … Asthma 'Causes' Mental Health Problems Among Children |
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Ambulance Victoria warns asthma suffers of severe allergy season
Herald Sun Associate Professor Tony Walker, Ambulance Victoria's general manager of regional services, said the allergy season seemed to have started earlier than normal this year. “We're already starting to see a number of severe asthma and related breathing … |
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 Daily Mail |
Asthma drug 'cut attacks by a fifth' even for those with severe form of the …
Daily Mail A DRUG that reduces the number of asthma attacks by more than a fifth could offer hope to hundreds of thousands of patients who suffer from the most severe form of the debilitating lung disease. Trials on nearly 1,000 people with uncontrolled asthma … |
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Vitamin D Insufficiency Linked to Severe Asthma Exacerbation
Food Consumer Wednesday Sept 12, 2012 (foodconsumer.org) — Children with asthma who have vitamin D insufficiency are at high risk for severe asthma exacerbation, according to a study in Respiratory and Critical Care Medicine. John M. Brehm at Children's Hospital of … |
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KaloBios commences KB003 Phase 2 trial in severe asthma
News-Medical.net KaloBios Pharmaceuticals, Inc. today announced that dosing has begun in a randomized, double-blind, placebo-controlled Phase 2 clinical trial of KB003, the company's anti-GM-CSF Humaneered monoclonal antibody, in subjects with severe asthma … |
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 New York Times (blog) |
Relief for Severe Asthma, at a High Price
New York Times (blog) For two decades, Patricia DiGiusto struggled with severe asthma. Powerful medications and frequent use of her inhaler could not prevent repeated trips to the emergency room. On one particularly bad night, Ms. DiGiusto watched from her hospital bed as … |
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| Related Articles |
Restoration of Corticosteroid Sensitivity by p38 Mitogen Activated Protein Kinase Inhibition in Peripheral Blood Mononuclear Cells from Severe Asthma.
PLoS One. 2012;7(7):e41582
Authors: Mercado N, Hakim A, Kobayashi Y, Meah S, Usmani OS, Chung KF, Barnes PJ, Ito K
Abstract
BACKGROUND: Severe asthma accounts for a small number of asthmatics but represents a disproportionate cost to health care systems. The underlying mechanism in severe asthma remains unknown but several mechanisms are likely to be involved because of a very heterogeneous profile. We investigated the effects of a p38MAPK inhibitor in corticosteroid sensitivity in peripheral blood mononuclear cells (PBMCs) from severe asthmatics and the profile of its responders.
METHODOLOGY/PRINCIPAL FINDINGS: Corticosteroid sensitivity was determined by measuring dexamethasone inhibition of CD3/28 and TNF-? induced IL-8 production in PBMCs by using ELISA. PBMCs from severe asthmatics were relatively less sensitive to dexamethasone (Dex) as compared to those of non-severe asthmatics and healthy volunteers. The IC(50) values of Dex negatively correlated with decreased glucocorticoid receptor (GR) nuclear translocation assessed using immunocytochemistry (r?=?-0.65; p<0.0005) and with decreased FEV(1) (% predicted) (r?=?0.6; p<0.0005). A p38?/? inhibitor (SB203580) restored Dex-sensitivity in a subpopulation of severe asthma that was characterized by a defective GR nuclear translocation, clinically by lower FEV(1) and higher use of oral prednisolone. We also found that SB203580 partially inhibited GR phosphorylation at serine 226, resulting in increased GR nuclear translocation in IL-2/IL-4 treated corticosteroid insensitive U937s.
CONCLUSIONS/SIGNIFICANCE: p38MAPK?/? is involved in defective GR nuclear translocation due to phosphorylation at Ser226 and this will be a useful biomarker to identify responders to p38MAPK?/? inhibitor in the future.
PMID: 22911818 [PubMed – in process]
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