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Reading Eagle |
Short Takes: Kempton Shindig, fighting asthma
Reading Eagle "Asthma can limit physical activity and is the number 1 reason for school absenteeism," said Michelle Niedermeier, community IPM coordinator for PA IPM, in a statement. "While asthma cannot be cured, it can be controlled with medication and by avoiding … |
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Express.co.uk |
Coughing or short of breath? KILLER lung disease could be mistaken for ASTHMA
Express.co.uk Experts suggest this could be because COPD is easily mistaken for asthma as both conditions display similar symptoms such as coughing, wheezing and shortness of breath. However, medics argue what is going on within the body is quite different. |
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A short review on structure and role of cyclic-3′,5′-adenosine monophosphate-specific phosphodiesterase 4 as a treatment tool.
J Res Pharm Pract. 2015 Oct-Dec;4(4):175-181
Authors: Eskandari N, Mirmosayyeb O, Bordbari G, Bastan R, Yousefi Z, Andalib A
Abstract
Cyclic nucleotide phosphodiesterases (PDEs) are known as a super-family of enzymes which catalyze the metabolism of the intracellular cyclic nucleotides, cyclic-3′,5′-adenosine monophosphate (cAMP), and cyclic-3′,5′-guanosine monophosphate that are expressed in a variety of cell types that can exert various functions based on their cells distribution. The PDE4 family has been the focus of vast research efforts over recent years because this family is considered as a prime target for therapeutic intervention in a number of inflammatory diseases such as asthma, chronic obstructive pulmonary disease, and rheumatoid arthritis, and it should be used and researched by pharmacists. This is because the major isoform of PDE that regulates inflammatory cell activity is the cAMP-specific PDE, PDE4. This review discusses the relationship between PDE4 and its inhibitor drugs based on structures, cells distribution, and pharmacological properties of PDE4 which can be informative for all pharmacy specialists.
PMID: 26645022 [PubMed – as supplied by publisher]
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KMAland |
Iowa Schools Fall Short for Children with Asthma
KMAland New research finds that Iowa schools are not making the grade when it comes to providing a healthy and safe learning environment for those children with asthma or allergies. The state meets just 16 of 23 core policy standards, according to the latest … Schoolboy treated for asthma died of anaphylactic reaction prompts calls for … |
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Schools Fall Short for Kids with Asthma
KGAN TV DES MOINES, IA (IOWA NEWS SERVICE) – As students across Iowa try to make the grade upon their return to class, new research shows schools in the state are falling short of the honor roll when it comes to protecting children with asthma or allergies. |
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Care for California kids with asthma falls short
Futurity: Research News “Asthma is one of the most common chronic pediatric conditions in the US and a major reason for emergency department visits and hospitalizations in children,” says Ulfat Shaikh, clinical quality officer at the California Department of Health Care … |
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Feeling Short of Breath? You May Have Asthma
Health Hub from Cleveland Clinic If you think that you may have asthma, it's a good idea to schedule a medical appointment. Your doctor can easily test you so that you know for sure. A lingering cold, persistent cough, or shortness of breath can all be signs of asthma, a common … |
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Related Articles |
Human rhinovirus and wheezing: short and long-term associations in children.
Pediatr Infect Dis J. 2013 Aug;32(8):827-33
Authors: van der Gugten AC, van der Zalm MM, Uiterwaal CS, Wilbrink B, Rossen JW, van der Ent CK
Abstract
OBJECTIVES: Human rhinoviruses (HRVs) have been suggested to play a role in the development of childhood wheezing. However, whether HRV is causally related to the development of wheezing or HRV-associated wheeze is merely an indicator of disease susceptibility is unclear. Our aim was to study the role of HRV during infancy in the development of lower respiratory disease during infancy and childhood.
METHODS: In a population-based birth cohort, during the 1st year of life, nose and throat swabs were collected on a monthly basis, regardless of any symptoms. Polymerase chain reaction was used to detect an extensive panel of respiratory pathogens. Lung function was measured before 2 months of age. Information on respiratory symptoms was collected by daily questionnaires and electronic patient files.
RESULTS: 1425 samples were collected in 140 infants. Both the presence of (single or multiple) pathogens (HRV equal to other pathogens) and increased respiratory system resistance were significantly associated with lower respiratory symptoms during infancy. HRV presence during infancy was not associated with the risk of wheezing at age 4, but every HRV episode with wheezing increased the risk of wheezing at age 4 (odds ratio 1.9, 1.1-3.5). This association weakened after adjustment for lung function (odds ratio 1.4, 0.7-2.9).
CONCLUSIONS: HRV and other viruses are associated with lower respiratory symptoms during infancy, as well as a high presymptomatic respiratory system resistance. HRV presence during infancy is not associated with childhood wheezing, but wheeze during a HRV episode is an indicator of children at high risk for childhood wheeze, partly because of a reduced neonatal lung function.
PMID: 23584579 [PubMed – indexed for MEDLINE]
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Montreal Gazette |
Flu Vaccination Up Among Asthma Patients, But Still Short of Targets
Pharmacy Times A new report from the CDC finds that almost 50% of asthma patients received a flu shot in the 2010-2011 season, compared with 36% of asthma patients in the 2005-2006 season. During the 2010-2011 flu season, Americans with asthma were more likely to … Avoid the gift that no one wants, the flu First flu fatality confirmed in Benton-Franklin Health District Ger Your Flu Shot; Avoid Being Sick During Holidays |
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RGS5 gene and therapeutic response to short acting bronchodilators in paediatric asthma patients.
Pediatr Pulmonol. 2012 Nov 28;
Authors: Labuda M, Laberge S, Brière J, Bérubé D, Krajinovic M
Abstract
Short-acting ?2-adrenergic receptor agonists are commonly used bronchodilators for symptom relief in asthmatics. Recent evidence demonstrated that prolonged exposure of cultured airway smooth muscle cells to ?2 agonists directly augments procontractile signaling pathways with the change in expression of regulator of G protein signaling 5 (RGS5). The aim of this study was to test whether genetic variants in RGS5 gene affect the response to short acting ?2-agonists. Bronchodilator responsiveness was assessed in 137 asthmatic children by % change in baseline forced expiratory volume in 1?sec (FEV(1) ) after administration of albuterol. The analyses were performed in patients with FEV(1) /FVC ratio below 0.9 (FVC-forced vital capacity, n?=?99). FEV(1) % change adjusted for baseline FEV(1) values was significantly different between genotypes of rs10917696 C/T polymorphism (P?=?0.008). The association remained significant with inclusion of age, sex, atopy, parental smoking, and controller medications into multivariate model (P?=?0.005). We also identified additive effect on the treatment outcome with previously published genetic variant G/A rs1544791 in phosphodiesterase 4 (PDE4D) gene. Carriers of two risk alleles (C and G) had adjusted mean % FEV(1) change value 4.6?±?1.3, while carriers of one and none of the risk alleles had 8.1?±?0.7% and 13.5?±?2.4%, respectively, P?=?0.001. Our work identifies a new genetic variant in RGS5 demonstrating additive effect with PDE4D, both implicated in modulation of asthma treatment. Pediatr Pulmonol. © 2012 Wiley Periodicals, Inc.
PMID: 23193110 [PubMed – as supplied by publisher]
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