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2 Minute Medicine |
Dexamethasone shows comparable efficacy to prednisone/prednisolone in …
2 Minute Medicine 1. A shorter course of dexamethasone, when compared to longer duration prednisone/prednisolone treatment for pediatric asthma exacerbation, showed no difference in terms of relapse rate. 2. Dexamethasone had a significantly lower incidence of vomiting … |
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Asthma care improvement initiative shows positive results among teens
Healio Recent data show that a quality improvement initiative, created by researchers at Cincinnati Children's Hospital, significantly improved asthma control and outcomes among high-risk adolescents. The study was conducted from 2007 to 2011 and included 322 … |
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New class of drug shows promise for treating asthma and COPD
YottaFire Scientists have developed a new drug (RPL554) that could treat obstructive airway diseases such as asthma and chronic obstructive pulmonary disease (COPD) in two ways at once, according to new research published in The Lancet Respiratory Medicine. |
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| Related Articles |
A Single-Nucleotide Polymorphism of Human Neuropeptide S Gene Originated from Europe Shows Decreased Bioactivity.
PLoS One. 2013;8(12):e83009
Authors: Deng C, He X, Hsueh AJ
Abstract
Using accumulating SNP (Single-Nucleotide Polymorphism) data, we performed a genome-wide search for polypeptide hormone ligands showing changes in the mature regions to elucidate genotype/phenotype diversity among various human populations. Neuropeptide S (NPS), a brain peptide hormone highly conserved in vertebrates, has diverse physiological effects on anxiety, fear, hyperactivity, food intake, and sleeping time through its cognate receptor-NPSR. Here, we report a SNP rs4751440 (L(6)-NPS) causing non-synonymous substitution on the 6(th) position (V to L) of the NPS mature peptide region. L(6)-NPS has a higher allele frequency in Europeans than other populations and probably originated from European ancestors ?25,000 yrs ago based on haplotype analysis and Approximate Bayesian Computation. Functional analyses indicate that L(6)-NPS exhibits a significant lower bioactivity than the wild type NPS, with ?20-fold higher EC50 values in the stimulation of NPSR. Additional evolutionary and mutagenesis studies further demonstrate the importance of the valine residue in the 6(th) position for NPS functions. Given the known physiological roles of NPS receptor in inflammatory bowel diseases, asthma pathogenesis, macrophage immune responses, and brain functions, our study provides the basis to elucidate NPS evolution and signaling diversity among human populations.
PMID: 24386135 [PubMed – as supplied by publisher]
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Philly.com |
Research Shows How Household Dogs Protect Against Asthma and Infection
Infection Control Today Children's risk for developing allergies and asthma is reduced when they are exposed in early infancy to a dog in the household, and now researchers have discovered a reason why. Exposure of mice to dust from houses where canine pets are permitted both … How Dogs Might Protect Kids Against Asthma: Gut Bacteria Dogs May Guard Babies Against Asthma, Allergies Having a dog protects against asthma and infection, study says |
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UCSF News Services |
Research Shows How Household Dogs Protect Against Asthma and Infection
UCSF News Services Children's risk for developing allergies and asthma is reduced when they are exposed in early infancy to a dog in the household, and now researchers have discovered a reason why. Exposure of mice to dust from houses where canine pets are permitted both … |
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LiveScience.com |
Research shows how household dogs protect against asthma and infection
Medical Xpress Children's risk for developing allergies and asthma is reduced when they are exposed in early infancy to a dog in the household, and now researchers have discovered a reason why. Exposure of mice to dust from houses where canine pets are permitted both … 'Dog Dust' May Combat Allergies and Asthma How household dogs protect against asthma and infection Want to Fight Allergies? Get a Dirty Dog |
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Drug Discovery & Development |
GSK, Theravance asthma drug shows improved lung function in study
Reuters The drug, already approved in the U.S. to treat chronic obstructive pulmonary disease (COPD) under the brand name Breo, proved more effective than fluticasone furoate alone for patients with moderate to severe asthma at the end of a 12-week treatment … GSK, Theravance Report Positive Results For FF/VI In Late Stage Asthma Study Theravance and Glaxo say asthma study succeeded |
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New clinical trial shows increased asthma control with FeNO-guided anti …
News-Medical.net A total of 187 non-smoking asthma patients (18-64 years) with perennial allergy and on regular inhaled corticosteroid (ICS) treatment were recruited at 17 primary health care centres in Sweden, randomly assigned to two groups and followed for one year. AEROCRINE AB : Aerocrine: First Primary Care Trial Supports FeNO-Guided … |
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ABC7Chicago.com |
New Study Shows Long-Lasting Treatment for Asthma Sufferers
ABC News Transcript for New Study Shows Long-Lasting Treatment for Asthma Sufferers. And now to a medical breakthrough tonight in the treatment of asthma, a condition that touches so many american families. Nearly 25 million people suffer from it, more than 2.5 … New asthma treatment has patients breathing easier New Treatment for Asthma Sufferers |
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