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WDJT |
Where There's Smoke, There's Fire, Allergies, & Asthma
WDJT If you've been dependent on those tissues lately, there's probably a good reason. Smoke from Canadian wildfires plus grass and tree pollen have played a doozy on our sinuses. Although allergists say Monday's rain and storms will help wash away some of … |
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Smoke from fireworks can cause trouble for those with asthma
WNDU-TV This weekend's fireworks are sure to dazzle, but for some, they could actually take their breath away. Experts at National Jewish Health warn that firework shows can produce enough second-hand smoke to cause breathing problems in people with asthma. |
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Cayce Swenson: Secondhand smoke painful for people with asthma
Madison.com Dear Editor: May is Asthma Awareness Month. As someone who has a sister with asthma, I'm doing my part to raise awareness about a major trigger for asthma attacks: secondhand smoke. One way I'm spreading the truth about secondhand smoke and other … |
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Is Secondhand Smoke Exposure Associated With Increased Exacerbation Severity Among Children Hospitalized for Asthma?
Hosp Pediatr. 2015 May;5(5):249-255
Authors: Andrews AL, Shirley N, Ojukwu E, Robinson M, Torok M, Wilson KM
Abstract
OBJECTIVE: To determine the association between secondhand smoke (SHS) exposure and length of stay (LOS) and other exacerbation severity indicators in children hospitalized for asthma.
METHODS: We conducted a retrospective chart review at 2 children’s hospitals. Patients aged 2 to 18 hospitalized for asthma in 2012 were included. Outcome variables included LOS, PICU, magnesium, and intravenous (IV) steroids. Bivariate analysis determined differences between SHS-exposed and non-SHS-exposed groups. Geometric means were used for LOS to account for skewed distribution. Logistic and zero-truncated negative binomial regression models were used to determine the independent association between SHS exposure and hospitalization severity indicators.
RESULTS: A total of 623 patients were included; 41% reported SHS exposure. Mean LOS was 47.5 hours. In the SHS-exposed group, LOS was 50.0 (95% confidence interval [CI] 46.7-54.0) and in the nonexposed group it was 45.8 (95% CI 43.4-48.4) (P = .02). In regression analysis, institution modified the effect of SHS exposure on LOS. At Children’s Hospital Colorado, SHS exposure was associated with a 20% increase in LOS (incidence rate ratio 1.2, 95% CI 1.1-1.3). At the Medical University of South Carolina, there was no significant association. SHS-exposed patients were more likely to receive IV steroids (odds ratio 1.6, 95% CI 1.1-2.3) CONCLUSIONS: Among children hospitalized for asthma, we identified a significant association at 1 institution between SHS exposure and LOS and found that IV steroid use was significantly associated with LOS at both institutions. Eliminating SHS exposure among children with asthma is important.
PMID: 25934808 [PubMed – as supplied by publisher]
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Medical Jane |
Cannabis Smoke May Benefit Asthma and Lung Functions
Medical Jane Regardless, many studies have shown that cannabis use may benefit asthma patients and enhance general lung function by acting as a bronchodilator, rather than a bronchoconstrictor. In fact, a new study in the Journal of Pharmacology and Experimental … |
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Examiner.com |
Children in poor families at risk for asthma, secondhand smoke
Examiner.com The authors concluded that family hardships are commonplace and associated with detectable serum cotinine level among children with asthma. The noted that family hardships and tobacco smoke exposure may be possible targets for interventions to reduce … |
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Some Older Adults With Asthma, COPD Still Smoke
WebMD WEDNESDAY, Jan. 7, 2015 (HealthDay News) — Close to half of U.S. adults over 40 who have trouble breathing due to asthma or COPD still continue to smoke, federal health officials reported Wednesday. The findings highlight the difficulty facing many … |
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Nearly Half of Older Adults With Asthma, COPD Still Smoke: CDC – WebMD
WebMD … (CDC) statistics come a day after the release of another agency report, which found that 15 percent of Americans between 40 and 79 years of age suffer from some form of lung obstruction — typically asthma or chronic obstructive pulmonary disease … |
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Nearly Half of Older Adults With Asthma, COPD Still Smoke: CDC
U.S. News & World Report WEDNESDAY, Jan. 7, 2015 (HealthDay News) — Close to half of U.S. adults over 40 who have trouble breathing due to asthma or COPD still continue to smoke, federal health officials reported Wednesday. The findings highlight the difficulty facing many … About 1 in 7 Older Adults Has Some Form of Lung Disease: CDC US Lung Obstruction Rates Steady at About 15% |
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Cigarette Smoke Induces uPAR in Vivo and Isoforms Selectively Contribute to Bronchial Epithelial Phenotype.
Am J Respir Cell Mol Biol. 2014 Dec 9;
Authors: Portelli MA, Stewart CE, Hall IP, Brightling CE, Sayers I
Abstract
The urokinase plasminogen activator receptor (uPAR) gene (PLAUR) has been identified as an asthma susceptibility gene, with polymorphisms within that gene being associated with baseline lung function, lung function decline and lung function in a smoking population. Soluble cleaved uPAR (scuPAR), a molecule identified as a marker of increased morbidity and mortality in a number of diseases, has itself been shown to be elevated in the airways of asthma and COPD patients. However, the functionality of soluble receptor isoforms and their relationship with an important initiator for obstructive lung disease, cigarette smoke, remains undefined. In this study, we set out to determine the effect of cigarette smoke on soluble uPAR isoforms, its regulatory pathway and the resultant effect on bronchial epithelial cell function. We identified a positive association between cigarette pack/years and uPAR expression in the airway bronchial epithelium of biopsies from asthma patients (n=27, P=0.0485). In vitro, cigarette smoke promoted cleavage of uPAR from the surface of bronchial epithelial cells (1.5X induction, P<0.0001) and induced the soluble spliced isoform through changes in mRNA expression (~2X change, P<0.001), driven by loss of endogenous 3`UTR suppression. Elevated expression of the soluble isoforms resulted in a pro-remodelling cell phenotype, characterised by increased proliferation and MMP-9 expression in primary bronchial epithelial cells. This suggests that cigarette smoke elevates soluble receptor isoforms in bronchial epithelial cells through direct (cleavage), and indirect (mRNA expression) means. These findings provide further insight into how cigarette smoke may influence changes in the airways of importance to airway remodelling and obstructive lung disease progression.
PMID: 25490122 [PubMed – as supplied by publisher]
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