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Spink5 And Adrb2 Haplotypes Are Risk Factors For Asthma In Mexican Pediatric Patients.
J Asthma. 2014 Sep 18;:1-23
Authors: Martínez-Aguilar N, Del Río-Navarro B, Navarro-Olivos E, García-Ortíz H, Orozco L, Jiménez-Morales S
Abstract
Abstract Background: Asthma is one of the most common respiratory diseases worldwide, and the complexity of its etiology has been widely documented. Chromosome 5q31-33 is one of the main loci implicated in asthma and asthma-related traits. IL13, CD14, and ADRB2, which are located in this risk locus, are among the genes most strongly associated with asthma susceptibility. Objectives: This study evaluated whether single-nucleotide polymorphisms or haplotypes at 5q31-33 conferred risk for asthma in Mexican-Mestizo pediatric patients. Methods: We performed a case-control study including 851 individuals, 421 of them affected with childhood-onset asthma and 430 ethnically matched unaffected subjects. We used the TaqMan Allelic Discrimination Assay to genotype 20 single-nucleotide polymorphisms within IL5, RAD50, IL13, IL4, CD14, SPINK5, HTR4, ADRB2, and IL12B. Results: Although no association was detected for any risk allele, three SPINK5 haplotypes (GGCT: p= 6 x 10(-6); AATC: p= 0.0001; AGTT: p= 0.0001) and five ADRB2 haplotypes (AGGACC: p=0.0014; AGGAAG: p=0.0002; TGAGAG: p=0.0001; AGGAAC: p=0.0002; AAGGAG: p=0.003) were associated with asthma. Notably, the AGTT SPINK5 haplotype exhibited a male gender-dependent association (p=7.6 x 10(-5)). Conclusion: Our results suggest that SPINK5 and ADRB2 haplotypes might play a role in the susceptibility to childhood-onset asthma.
PMID: 25233048 [PubMed – as supplied by publisher]
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