Tag: stress

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Sonchus asper extract inhibits LPS-induced oxidative stress and pro-inflammatory cytokine production in RAW264.7 macrophages.

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Sonchus asper extract inhibits LPS-induced oxidative stress and pro-inflammatory cytokine production in RAW264.7 macrophages.

Nutr Res Pract. 2015 Dec;9(6):579-585

Authors: Wang L, Xu ML, Liu J, Wang Y, Hu JH, Wang MH

Abstract
BACKGROUND/OBJECTIVES: Sonchus asper is used extensively as an herbal anti-inflammatory for treatment of bronchitis, asthma, wounds, burns, and cough; however, further investigation is needed in order to understand the underlying mechanism. To determine its mechanism of action, we examined the effects of an ethyl acetate fraction (EAF) of S. asper on nitric oxide (NO) production and prostaglandin-E2 levels in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages.
MATERIALS/METHODS: An in vitro culture of RAW264.7 macrophages was treated with LPS to induce inflammation.
RESULTS: Treatment with EAF resulted in significant suppression of oxidative stress in RAW264.7 macrophages as demonstrated by increased endogenous superoxide dismutase (SOD) activity and intracellular glutathione levels, decreased generation of reactive oxygen species and lipid peroxidation, and restoration of the mitochondrial membrane potential. To confirm its anti-inflammatory effects, analysis of expression of inducible NO synthase, cyclooxygenase-2, tumor necrosis factor-?, and the anti-inflammatory cytokines IL-1? and IL-6 was performed using semi-quantitative RT-PCR. EAF treatment resulted in significantly reduced dose-dependent expression of all of these factors, and enhanced expression of the antioxidants MnSOD and heme oxygenase-1. In addition, HPLC fingerprint results suggest that rutin, caffeic acid, and quercetin may be the active ingredients in EAF.
CONCLUSIONS: Taken together, findings of this study imply that the anti-inflammatory effect of EAF on LPS-stimulated RAW264.7 cells is mediated by suppression of oxidative stress.

PMID: 26634045 [PubMed – as supplied by publisher]

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Prenatal stress and childhood asthma in the offspring: role of age at onset.

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Prenatal stress and childhood asthma in the offspring: role of age at onset.

Eur J Public Health. 2015 Jun 25;

Authors: Liu X, Olsen J, Agerbo E, Yuan W, Sigsgaard T, Li J

Abstract
BACKGROUND: Asthma is a heterogeneous disorder with different phenotypes, and age at onset may define part of them. Little is known about possible association between prenatal stress and asthma phenotypes according to age at onset. We aim to investigate whether there is an association between prenatal stress and asthma, and if so, whether such an association differs according to age at asthma onset.
METHODS: We carried out a cohort study based on several national registers in Denmark, including all live singletons born during 1996-2007 in Denmark (N = 750 058). We identified children born to mothers who lost a close relative (a child, partner/spouse, a parent or a sibling) 1 year prior to or during pregnancy as the bereaved group. Using Cox proportional hazards regression model, we evaluated the hazard ratios (HRs) for asthma in children of bereaved mothers, compared with children of non-bereaved mothers.
RESULTS: Prenatal stress following maternal bereavement was associated with a marginally increased risk of asthma events in children aged 0-3 years [HR = 1.04, 95% confidence interval (CI): 1.00-1.07], while unexpected bereavement was associated with a higher risk (HR = 1.13, 95% CI: 1.02-1.24). There was no association between prenatal bereavement and asthma in children aged 4-15 years (HR = 1.02, 95% CI: 0.96-1.09).
CONCLUSIONS: Prenatal stress is possibly associated with asthma events in children aged 0-3 years, but not with asthma in children aged 4-15 years irrespective of age at asthma onset.

PMID: 26116689 [PubMed – as supplied by publisher]

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Stress at work increases risk of developing asthma, according to major new … – The Independent


The Independent

Stress at work increases risk of developing asthma, according to major new …
The Independent
It supports previous studies pointing to a link between the development of asthma and stress, according to researchers. The use of temporary contracts and other “flexible forms of contracting” as well as downsizing, are cited as factors which “increase …
Job loss fears may boost first-time asthma riskMedical Xpress
Work-Stress And Asthma: Fear Of Losing Your Job Linked To Developing First …Medical Daily
Job fears may increase asthma riskYahoo News UK
Counsel & Heal –New Zealand Doctor Online
all 8 news articles »

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Mouse Study Finds Prenatal Stress Increases Asthma Risk in Child – PsychCentral.com


PsychCentral.com

Mouse Study Finds Prenatal Stress Increases Asthma Risk in Child
PsychCentral.com
Now, a new study finds that prenatal stress may also be linked to the development of asthma. Researchers at the Harvard School of Public Health found that stress among pregnant mice — even a single bout — led to an increased risk of allergy-induced …

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Study Finds Link Between Maternal Stress and Asthma in Offspring – Nature World News


Nature World News

Study Finds Link Between Maternal Stress and Asthma in Offspring
Nature World News
This isn't the first time that stress has been linked to asthma. A recent study had found that mothers who suffer from stressful events such as a divorce, death of a loved one or job loss tend to have a higher risk of having children with asthma or eczema.

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