Two-part Safety, Tolerability, Pharmacodynamic and -Kinetic Study of Inhaled AZD8871 in Asthmatic and COPD Subjects

Conditions:   Asthma (Part 1);   COPD (Part 2)
Interventions:   Drug: Dose 1, AZD8871 50 ?g (Part 1);   Drug: Dose 2, AZD8871 100 ?g (Part 1);   Drug: Dose 3, AZD8871 300 ?g (Part 1);   Drug: Dose 4, AZD8871 600 µg (Part 1);   Drug: Dose 5, AZD8871 1200 µg (Part 1);   Drug: Dose 6, AZD8871 1800 ?g (Part 1);   Drug: Placebo, AZD8871 placebo (Part 1);   Drug: Treatment A, AZD8871 dose A (Part 2);   Drug: Treatment B, AZD8871 dose B (Part 2);   Drug: Treatment C, Indacaterol 150 ?g (Part 2);   Drug: Treatment D, Tiotropium 18 ?g (Part 2)
Sponsor:   AstraZeneca
Not yet recruiting – verified October 2015

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Asthma management drugs can affect children’s growth, says new study – ChristianToday


ChristianToday

Asthma management drugs can affect children's growth, says new study
ChristianToday
Corticosteroids are popular drugs prescribed in the management of asthma, but a new study finds that certain types may affect growth in very young children. In a research presentation given at the annual European Society for Pediatric Endocrinology

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Caregiver treatment satisfaction is improved together with children’s asthma control: Prospective study for budesonide monotherapy in school-aged children with uncontrolled asthma symptoms.

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Caregiver treatment satisfaction is improved together with children’s asthma control: Prospective study for budesonide monotherapy in school-aged children with uncontrolled asthma symptoms.

Allergol Int. 2015 Oct;64(4):371-6

Authors: Yoshihara S, Kanno N, Fukuda H, Arisaka O, Arita M, Sekine K, Yamaguchi K, Tsuchida A, Yamada Y, Watanabe T, Shimizu T, Nishikawa K, Nishimuta T

Abstract
BACKGROUND: If asthmatic children cannot obtain sufficient control of their disease, not only do they suffer from asthma symptoms, but the daily life activities of their caregivers are also disrupted. We investigated the effectiveness of an inhaled corticosteroid (ICS) for symptom control in previously ICS-untreated school-aged asthmatic children as well as caregiver treatment satisfaction (CTS).
METHODS: A multicenter, open-label, single-arm study on 12-week ICS (budesonide Turbuhaler(®)) monotherapy was undertaken in subjects aged 5-15 years with bronchial asthma not treated with ICS during the previous 3 months. At 0, 4, 8, and 12 weeks after start of ICS administration, Japanese Pediatric Asthma Control Program (JPAC) scores, and CTS scores were summated and lung function measured. At weeks 0 and 12, questionnaires on caregiver anxiety were also assessed.
RESULTS: Seventy-five patients were enrolled, and 69 assessed. Ninety percent of subjects had been treated with asthma controller medication except ICS before study enrollment. JPAC score and CTS score were improved significantly at weeks 4, 8, and 12 (p < 0.001). With regard to CTS, more than half of caregivers showed a perfect score at weeks 8 and 12. There was a significant correlation between JPAC score and CTS score. Lung function and caregiver anxiety were also improved, and good compliance with treatment was observed during the intervention.
CONCLUSIONS: If treating ICS-untreated school-aged asthmatic children with uncontrolled symptoms, ICS monotherapy can improve CTS along with improving asthma control.

PMID: 26433534 [PubMed – in process]

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Study: Good gut bacteria may affect babies’ risk of asthma – KRQE News 13


KRQE News 13

Study: Good gut bacteria may affect babies' risk of asthma
KRQE News 13
WASHINGTON (AP) — Gut checks suggest that not having enough of certain “good” intestinal germs early in life may increase babies' risk of developing asthma, according to a new study of more than 300 children. Wait: What could gut bacteria have to do …
Missing gut bacteria may lead to asthma: studyWaterloo Record

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(Video) Study: Infants treated for asthma before two have stunted growth – Nature World Report


Nature World Report

(Video) Study: Infants treated for asthma before two have stunted growth
Nature World Report
Finnish researchers suggested that infants given asthma medications during their first 2 years of age have a risk of stunted growth in later life. A report presented by 54th Annual European Society for Paediatric Endocrinology Meeting unveiled the
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Asthma medication stunts growth among infants: Finnish ResearchNYC Today
Times Gazette –Pioneer News –Morning Ticker
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‘Too Clean’ Environment May Lead to Childhood Asthma, Study Suggests – Latinos Post


Latinos Post

'Too Clean' Environment May Lead to Childhood Asthma, Study Suggests
Latinos Post
According to the study published at the Science Translational Medicine, the risk of developing asthma is greater for 3-month-old infants who have lower levels of the four identified types of gut bacteria – bacteria that do not thrive in overly cleaned

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Kids May Be More Likely to Get Asthma if Grandma Smoked While Pregnant: Study … – WebMD


Chicago Tribune

Kids May Be More Likely to Get Asthma if Grandma Smoked While Pregnant: Study
WebMD
"We found that smoking in previous generations can influence the risk of asthma in subsequent generations. This may also be important in the transmission of other exposures and diseases," study co-author Caroline Lodge said in a European Lung …
Study hints at asthma link passed from smokers to grandchildrenChicago Tribune
Could asthma be inherited from grandmothers who smoke?Medical News Today
Grandma's Smoking Habit Might Be Why You Have AsthmaTIME
Medical Daily –U.S. News & World Report
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Study hints at asthma link passed from smokers to grandchildren – Chicago Tribune


Chicago Tribune

Study hints at asthma link passed from smokers to grandchildren
Chicago Tribune
Children whose grandmothers smoked during pregnancy are at increased risk for asthma, even if their own mothers did not smoke, a new study suggests. It's known that smoking can cause changes in gene activity. The new study findings suggest that those …
Could asthma be inherited from grandmothers who smoke?Medical News Today
Grandmothers Who Smoke Cigarettes During Pregnancy May Increase Asthma Risk In Medical Daily
Grandma's Smoking Habit Might Be Why You Have AsthmaTIME
U.S. News & World Report –EurekAlert (press release)
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