Breathe Well Live Well
|
Children Using Asthma Inhalers Shorter Than Peers, Study Says
Design & Trend (Photo : Wikipedia) Asthma treatments during the first year of treatment have been shown to suppress growth in children. New research suggests that inhaled corticosteroids, drugs given to people suffering from asthma, can also suppress growth in … |
View full post on asthma – Google News
University of Rochester Newsroom |
$3.6 Million Grant Funds Asthma Study for Urban Teens
University of Rochester Newsroom As schoolchildren enter their teenage years, they tend to start making more of their own health care decisions. But that transition can be challenging, and certain behaviors — such as making sure they take their daily asthma medication — can … |
View full post on asthma – Google News
Condition: Persistent Asthma
Interventions: Drug: Fluticasone propionate Multidose Dry Powder Inhaler (Fp MDPI); Drug: Fluticasone propionate /salmeterol MDPI (FS MDPI); Drug: Fluticasone propionate HFA Inhalation Aerosol; Drug: Fluticasone propionate/salmeterol dry powder formulation
Sponsors: Teva Pharmaceutical Industries; Teva Branded Pharmaceutical Products, R&D Inc.
Recruiting – verified June 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Tech Times |
Childhood obesity triggering asthma epidemic: Study
Tech Times "In the past we haven't been sure whether a high BMI causes asthma, or if asthma causes high BMI, or another variable entirely is responsible for both," said David Evans, co-author of the study "We tested genes that we knew were related to BMI. If … Rise in BMI Ups the Risk of Developing Asthma During Mid-Childhood Higher BMI Increases Asthma Risk in Mid-Childhood: Study Body Mass Index Linked To An Increased Chance Of Asthma, Genetic Evidence … |
View full post on asthma – Google News
Condition: Asthma
Interventions: Drug: Respimat® Budesonide low dose; Drug: Respimat® Budesonide high dose; Drug: Turbohaler® Budesonide; Drug: Placebo
Sponsor: Boehringer Ingelheim
Completed – verified July 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Headlines & Global News |
New Drug Could Possibly Treat Asthma and Allergies: Study
Headlines & Global News For the study, the researchers recruited 39 people with allergies and 39 people with mild asthma. They were randomly given quilizumab or a placebo. The researchers were able to measure IgE levels through the participants' bloodstream after they were … |
View full post on asthma – Google News
|
Obesity and asthma linked in study
Daily Mail Professor David Evans from the University of Queensland Diamantina Institute said the researchers employed a new method that uses both genetic information and observational data in order to assess whether BMI has a causal effect on asthma. |
View full post on asthma – Google News
Headlines & Global News |
Higher BMI Increases Asthma Risk in Mid-Childhood: Study
Headlines & Global News According to the analysis, the researchers stated that for every extra unit of BMI, there was a relative increase in asthma risk by 55 percent. The team said that in order to reduce the risk of childhood asthma risk, children should maintain normal BMI … Obesity and excess weight in childhood may increase asthma risk, study finds Childhood obesity is fuelling asthma epidemic Body Mass Index Linked To An Increased Chance Of Asthma, Genetic Evidence … |
View full post on asthma – Google News
The Guardian |
Obesity and excess weight in childhood may increase asthma risk, study finds
The Guardian Excess weight and obesity in children may be fuelling the asthma epidemic facing many countries, a joint study from Australian and UK researchers has found, prompting peak asthma groups to re-emphasise the importance of a healthy lifestyle in childhood. Childhood obesity is fuelling asthma epidemic Body Mass Index Linked To An Increased Chance Of Asthma, Genetic Evidence … Genetic evidence that body mass increases the risk of asthma in mid-childhood |
View full post on asthma – Google News
| Related Articles |
Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study.
Lancet Diabetes Endocrinol. 2014 Jun 25;
Authors: Vimaleswaran KS, Cavadino A, Berry DJ, LifeLines Cohort Study investigators, Jorde R, Dieffenbach AK, Lu C, Alves AC, Heerspink HJ, Tikkanen E, Eriksson J, Wong A, Mangino M, Jablonski KA, Nolte IM, Houston DK, Ahluwalia TS, van der Most PJ, Pasko D, Zgaga L, Thiering E, Vitart V, Fraser RM, Huffman JE, de Boer RA, Schöttker B, Saum KU, McCarthy MI, Dupuis J, Herzig KH, Sebert S, Pouta A, Laitinen J, Kleber ME, Navis G, Lorentzon M, Jameson K, Arden N, Cooper JA, Acharya J, Hardy R, Raitakari O, Ripatti S, Billings LK, Lahti J, Osmond C, Penninx BW, Rejnmark L, Lohman KK, Paternoster L, Stolk RP, Hernandez DG, Byberg L, Hagström E, Melhus H, Ingelsson E, Mellström D, Ljunggren O, Tzoulaki I, McLachlan S, Theodoratou E, Tiesler CM, Jula A, Navarro P, Wright AF, Polasek O, International Consortium for Blood Pressure (ICBP), Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, Global Blood Pressure Genetics (Global BPGen) consortium, Caroline Hayward, Wilson JF, Rudan I, Salomaa V, Heinrich J, Campbell H, Price JF, Karlsson M, Lind L, Michaëlsson K, Bandinelli S, Frayling TM, Hartman CA, Sørensen TI, Kritchevsky SB, Langdahl BL, Eriksson JG, Florez JC, Spector TD, Lehtimäki T, Kuh D, Humphries SE, Cooper C, Ohlsson C, März W, de Borst MH, Kumari M, Kivimaki M, Wang TJ, Power C, Brenner H, Grimnes G, van der Harst P, Snieder H, Hingorani AD, Pilz S, Whittaker JC, Järvelin MR, Hyppönen E
Abstract
BACKGROUND: Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25(OH)D concentration is causally associated with blood pressure and hypertension risk.
METHODS: In this mendelian randomisation study, we generated an allele score (25[OH]D synthesis score) based on variants of genes that affect 25(OH)D synthesis or substrate availability (CYP2R1 and DHCR7), which we used as a proxy for 25(OH)D concentration. We meta-analysed data for up to 108?173 individuals from 35 studies in the D-CarDia collaboration to investigate associations between the allele score and blood pressure measurements. We complemented these analyses with previously published summary statistics from the International Consortium on Blood Pressure (ICBP), the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and the Global Blood Pressure Genetics (Global BPGen) consortium.
FINDINGS: In phenotypic analyses (up to n=49?363), increased 25(OH)D concentration was associated with decreased systolic blood pressure (? per 10% increase, -0·12 mm Hg, 95% CI -0·20 to -0·04; p=0·003) and reduced odds of hypertension (odds ratio [OR] 0·98, 95% CI 0·97-0·99; p=0·0003), but not with decreased diastolic blood pressure (? per 10% increase, -0·02 mm Hg, -0·08 to 0·03; p=0·37). In meta-analyses in which we combined data from D-CarDia and the ICBP (n=146?581, after exclusion of overlapping studies), each 25(OH)D-increasing allele of the synthesis score was associated with a change of -0·10 mm Hg in systolic blood pressure (-0·21 to -0·0001; p=0·0498) and a change of -0·08 mm Hg in diastolic blood pressure (-0·15 to -0·02; p=0·01). When D-CarDia and consortia data for hypertension were meta-analysed together (n=142?255), the synthesis score was associated with a reduced odds of hypertension (OR per allele, 0·98, 0·96-0·99; p=0·001). In instrumental variable analysis, each 10% increase in genetically instrumented 25(OH)D concentration was associated with a change of -0·29 mm Hg in diastolic blood pressure (-0·52 to -0·07; p=0·01), a change of -0·37 mm Hg in systolic blood pressure (-0·73 to 0·003; p=0·052), and an 8·1% decreased odds of hypertension (OR 0·92, 0·87-0·97; p=0·002).
INTERPRETATION: Increased plasma concentrations of 25(OH)D might reduce the risk of hypertension. This finding warrants further investigation in an independent, similarly powered study.
FUNDING: British Heart Foundation, UK Medical Research Council, and Academy of Finland.
PMID: 24974252 [PubMed – as supplied by publisher]
View full post on pubmed: asthma