Effect of prenatal supplementation with vitamin D on asthma or recurrent wheezing in offspring by age 3 years – Pharmacy Today, American Pharmacists Association, pharmacist.com


JAMA: The Journal of the American Medical Association

Effect of prenatal supplementation with vitamin D on asthma or recurrent wheezing in offspring by age 3 years
Pharmacy Today, American Pharmacists Association, pharmacist.com
Lack of vitamin D during pregnancy can lead to breathing disorders early in a child's life. Researchers tested whether prenatal vitamin D supplementation could prevent asthma or recurrent wheezing by administering specific doses to 876 women aged …
Prenatal Vitamin D and Baby's Asthma RiskWebMD
Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years: The JAMA: The Journal of the American Medical Association
Lower Asthma Risk From Prenatal Vitamin D Unconfirmed But Supplement Isn't a Bad Idea: ExpertsLatinos Health
EurekAlert (press release)
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Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years: The … – JAMA: The Journal of the American Medical Association


JAMA: The Journal of the American Medical Association

Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years: The
JAMA: The Journal of the American Medical Association
Importance Asthma and wheezing begin early in life, and prenatal vitamin D deficiency has been variably associated with these disorders in offspring. Objective To determine whether prenatal vitamin D (cholecalciferol) supplementation can prevent asthma
Prenatal Vitamin D and Baby's Asthma RiskWebMD
Vitamin D supplementation during pregnancy, risk of asthma, wheezing in offspring The JAMA Network JournalsEurekAlert (press release)
Does Prenatal Supplementation With Vitamin D Affect Childhood Asthma?MedicalResearch.com (blog)

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Vitamin D supplementation during pregnancy, risk of asthma, wheezing in offspring – Science Codex


JAMA: The Journal of the American Medical Association

Vitamin D supplementation during pregnancy, risk of asthma, wheezing in offspring
Science Codex
Asthma often begins in early childhood and is the most common chronic childhood disorder. The incidence has increased during the last half-century in westernized societies. Vitamin D deficiency has also become a common health problem in westernized …
Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years: The JAMA: The Journal of the American Medical Association

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Can Vitamin D Supplementation Help Cut Colds in Asthma? – Monthly Prescribing Reference (registration)

Can Vitamin D Supplementation Help Cut Colds in Asthma?
Monthly Prescribing Reference (registration)
(HealthDay News) — Vitamin D supplementation does not reduce cold severity or frequency among adults with mild-to-moderate asthma, according to a study published online Nov. 5 in the American Journal of Respiratory and Critical Care Medicine.

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Double-blind randomised placebo-controlled trial of bolus-dose vitamin D3 supplementation in adults with asthma (ViDiAs).

Double-blind randomised placebo-controlled trial of bolus-dose vitamin D3 supplementation in adults with asthma (ViDiAs).

Thorax. 2015 Feb 27;

Authors: Martineau AR, MacLaughlin BD, Hooper RL, Barnes NC, Jolliffe DA, Greiller CL, Kilpin K, McLaughlin D, Fletcher G, Mein CA, Hoti M, Walton R, Grigg J, Timms PM, Rajakulasingam RK, Bhowmik A, Rowe M, Venton TR, Choudhury AB, Simcock DE, Sadique Z, Monteiro WR, Corrigan CJ, Hawrylowicz CM, Griffiths CJ

Abstract
RATIONALE: Asthma exacerbations are commonly precipitated by viral upper respiratory infections (URIs). Vitamin D insufficiency associates with susceptibility to URI in patients with asthma. Trials of vitamin D in adults with asthma with incidence of exacerbation and URI as primary outcome are lacking.
OBJECTIVE: To conduct a randomised controlled trial of vitamin D3 supplementation for the prevention of asthma exacerbation and URI (coprimary outcomes).
MEASUREMENTS AND METHODS: 250 adults with asthma in London, UK were allocated to receive six 2-monthly oral doses of 3?mg vitamin D3 (n=125) or placebo (n=125) over 1?year. Secondary outcomes included asthma control test and St George’s Respiratory Questionnaire scores, fractional exhaled nitric oxide and concentrations of inflammatory markers in induced sputum. Subgroup analyses were performed to determine whether effects of supplementation were modified by baseline vitamin D status or genotype for 34 single nucleotide polymorphisms in 11 vitamin D pathway genes.
MAIN RESULTS: 206/250 participants (82%) were vitamin D insufficient at baseline. Vitamin D3 did not influence time to first severe exacerbation (adjusted HR 1.02, 95% CI 0.69 to 1.53, p=0.91) or first URI (adjusted HR 0.87, 95% CI 0.64 to 1.16, p=0.34). No clinically important effect of vitamin D3 was seen on any of the secondary outcomes listed above. The influence of vitamin D3 on coprimary outcomes was not modified by baseline vitamin D status or genotype.
CONCLUSIONS: Bolus-dose vitamin D3 supplementation did not influence time to exacerbation or URI in a population of adults with asthma with a high prevalence of baseline vitamin D insufficiency.
TRIAL REGISTRATION NUMBER: NCT00978315 (ClinicalTrials.gov).

PMID: 25724847 [PubMed – as supplied by publisher]

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Vitamin D supplementation does not improve asthma treatment, symptoms – EurekAlert (press release)

Vitamin D supplementation does not improve asthma treatment, symptoms
EurekAlert (press release)
In adults with persistent asthma and low vitamin D levels, treatment with vitamin D3 did not reduce the rate of treatment failure or exacerbation of symptoms, according to a study published by JAMA. The study is being released early online to coincide

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