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News from the University of Massachusetts |
SOM 2016 capstones target childhood asthma, food insecurity, diabetes among homeless
News from the University of Massachusetts Malek Mazzawi helped families of children with asthma reduce their absences from school by improving their home environments, making them less prone to asthma attacks. Micaela Atkins worked to help the homeless manage their diabetes. Kathryn Bailey … |
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Researchers identify hCRTh2 protein as possible therapeutic target for asthma
News-Medical.net Patients with asthma have chronic lung inflammation that results in sporadic narrowing of the airways and difficulty breathing. Symptoms and severity are variable among individuals; however, the cells and inflammatory factors that trigger asthmatic … |
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Lung Disease News |
Potential Target for Severe Asthma, Other Chronic Inflammatory Diseases Identified
Lung Disease News From previous research it was known that Dkk-1, a protein produced by platelets (blood cells responsible for clotting), inhibits tissue repair, a feature that is common in chronic inflammatory disorders such as asthma, autoimmune diseases and cancer … |
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Medical Xpress |
Study identifies new target for severe asthma, chronic inflammatory diseases
Medical Xpress Chronic inflammation is commonly found in asthma, autoimmune diseases, cancer, and viral infections, and it's characterized by constant activation of platelets with unhealed tissue damage. Scientists who have studied the Dkk-1 protein were aware that … |
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| Related Articles |
Cutting Edge: AhR Is a Molecular Target of Calcitriol in Human T Cells.
J Immunol. 2015 Aug 14;
Authors: Takami M, Fujimaki K, Nishimura MI, Iwashima M
Abstract
The immunoregulatory functions of vitamin D have been well documented in various immunological disorders, including multiple sclerosis, arthritis, and asthma. IL-10 is considered a chief effector molecule that promotes the vitamin D-induced immunosuppressive states of T cells and accessory cells. In this article, we demonstrate that the active form of vitamin D, 1,25-dihydroxyvitamin D3 (calcitriol), has a profound inhibitory effect on the development of human Th9, a CD4 T cell subset that is highly associated with asthma, in an IL-10-independent manner. Our data show that calcitriol represses the expression of BATF, a transcription factor essential for Th9, via suppressing the expression of aryl hydrocarbon receptor, without an increase in IL-10. The data show a novel link between vitamin D and two key transcription factors involved in T cell differentiation.
PMID: 26276877 [PubMed – as supplied by publisher]
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2 Minute Medicine |
Syndecan-4 identified as novel target for asthma treatment [PreClinical]
2 Minute Medicine Study Rundown: Asthma, an immune system disorder characterized by airway inflammation and difficulty breathing, affects about 25 million people in the United States alone. Both long- and short-term medications are available for regulating inflammation … |
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Target neurons to relieve asthma
Nature.com Silencing signals from pain-sensing nerve cells in the lungs reduces the symptoms of asthma in mice. When stimulated by allergens, these neurons cause airways to constrict and trigger symptoms such as coughing and wheezing. Bruce Levy and Clifford … |
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Drug Target for Asthma Discovered
Drug Discovery & Development The over-active immune cells responsible for asthma depend on the gene BCL11B to develop into mature cells, according to a study published in the Journal of Experimental Medicine. The identification of this gene's role could help in the search for … |
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Medical Xpress |
Drug target for asthma discovered
Medical Xpress The over-active immune cells responsible for asthma depend on the gene BCL11B to develop into mature cells, according to a study published in the Journal of Experimental Medicine. The identification of this gene's role could help in the search for … |
View full post on asthma – Google News
HCPLive |
Asthma Therapy Target Identified
HCPLive Researchers from the Medical College of Wisconsin believe this discovery is the first step in developing a novel type of asthma therapy which could be designed to prevent its onset in young children. In previous research, the investigators found a … |
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