Children Often Rate Their Asthma Worse Than Parents Report – Medscape


VOXXI

Children Often Rate Their Asthma Worse Than Parents Report
Medscape
ATLANTA — Parental assessment of a child's asthma severity can sometimes underestimate the child's level of discomfort and control, according to the results of a study presented here at the American College of Allergy, Asthma & Immunology 2014.
How an orange connected asthma to dangerous food allergiesVOXXI
American College of Allergy, Asthma & Immunology, Nov. 6-10Doctors Lounge
Mice worse for asthma than cockroachesHealthCentral.com
Huffington Post –Bloomer Advance (subscription)
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Mouse Infestations Cause More Asthma Symptoms than Cockroach Exposure – Newswise (press release)


Counsel & Heal

Mouse Infestations Cause More Asthma Symptoms than Cockroach Exposure
Newswise (press release)
Past research has been inconsistent in determining the relative effects of mouse droppings vs. cockroach exposure on asthma in children. According to a study being presented at the American College of Allergy, Asthma and Immunology (ACAAI) Annual …
Does father really know best? Maybe not when it comes to controlling asthmaMedical Xpress
Caregivers are not Educated enough about Asthma ManagementCounsel & Heal
Exposure to indoor air pollution affects children's lungsNews-Medical.net
Zee News –TIME
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UCLA study: Asthma harms more than just the lungs, may be more harmful than … – News-Medical.net


Zee News

UCLA study: Asthma harms more than just the lungs, may be more harmful than
News-Medical.net
Asthma may be more harmful than was previously thought, according to UCLA researchers who found that genetic damage is present in circulating, or peripheral, blood. Doctors previously thought that the genetic damage it caused was limited to the lungs.
Asthma could affect entire body, not just lungsZee News
New study finds asthma more harmful than previously thoughtExaminer.com

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COPD And Asthma Treatment Involves More Than Just Medication; Combination … – Medical Daily


Medical Daily

COPD And Asthma Treatment Involves More Than Just Medication; Combination
Medical Daily
COPD afflicts a patient's lungs, most often in the form of the flu, asthma, chronic bronchitis, emphysema, and lung cancer. Secondhand causes include air pollution, secondhand smoke, occupational dust and chemicals, heredity, and a childhood of
Combination therapy for COPD associated with better outcomesMedical Xpress
Drug Combination Better than LABAs Alone for COPDHealthline
Combo Therapy Best for COPD: StudyHealthDay
2 Minute Medicine
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The orl rat is more responsive to methacholine challenge than wild type.

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The orl rat is more responsive to methacholine challenge than wild type.

Pulm Pharmacol Ther. 2014 Sep 10;

Authors: Rodriguez E, Barthold JS, Kreiger PA, Armani MH, Wang J, Michelini KA, Wolfson MR, Boyce R, Barone CA, Zhu Y, Waldman SA, Shaffer TH

Abstract
BACKGROUND: This study presents an animal model of native airway hyperresponsiveness (AHR). AHR is a fundamental aspect of asthma and reflects an abnormal response characterized by airway narrowing following exposure to a wide variety of non-immunological stimuli. Undescended testis (UDT) is one of the most common male congenital anomalies. The orl rat is a Long Evans substrain with inherited UDT. Since boys born with congenital UDT are more likely to manifest asthma symptoms, the main aim in this study was to investigate the alternative hypothesis that orl rats have greater AHR to a methacholine aerosol challenge than wild type rats.
METHODS: Long Evans wild type (n=9) and orl (n=13) rats were anesthetized, tracheostomized, and mechanically ventilated at 4 weeks of age. Escalating concentrations of inhaled methacholine were delivered. The methacholine potency and efficacy in the strains were measured. Respiratory resistance was the primary endpoint. After the final methacholine aerosol challenge, the short-acting ?2-adrenoceptor agonist albuterol was administered as an aerosol and lung/diaphragm tissues were assayed for interleukin (IL)-4, IL-6, and tumor necrosis factor (TNF)-?. Histological and histomorphometrical analyses were performed.
RESULTS: The methacholine concentration-response curve in the orl group indicated increased sensitivity, hyperreactivity, and exaggerated maximal response in comparison with the wild type group, indicating that orl rats had abnormally greater AHR responses to methacholine. Histological findings in orl rats showed the presence of eosinophils, unlike wild type rats. ?2-adrenoceptor agonist intervention resulted in up-regulation of IL-4 diaphragmatic levels and down-regulation of IL-4 and IL-6 in the lungs of orl rats.
CONCLUSION: orl rats had greater AHR than wild type rats during methacholine challenge, with higher IL-4 levels in diaphragmatic tissue homogenates. Positive immunostaining for IL-4 was detected in lung and diaphragmatic tissue in both strains. This model offers advantages over other pre-clinical murine models for studying potential mechanistic links between cryptorchidism and asthma. This animal model may be useful for further testing of compounds/therapeutics options for treating AHR.

PMID: 25218882 [PubMed – as supplied by publisher]

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Elderly asthma patients had greater airway involvement than younger patients – Healio

Elderly asthma patients had greater airway involvement than younger patients
Healio
Researchers in Japan conducted a retrospective analysis on 45 elderly patients (aged more than 65 years) with asthma (mean age, 73.1 years; 34 women; median disease duration, 12.7 years) and 67 nonelderly patients with asthma (mean age, 48.6 years; …

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Heart disease higher locally than Cincinnati – Georgetown News Democrat

Heart disease higher locally than Cincinnati
Georgetown News Democrat
For eight out of 10 conditions discussed in the survey, people with a lower level of education had the condition more often than those with more education, as was the case for asthma, diabetes, high blood pressure, chronic lung disease, heart trouble
More locals facing serious illness, poll showsCincinnati.com
Feeling low? You're not alone. Chronic illness rates on the rise in CincinnatiCincinnati Business Courier

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More than a million people suffering from asthma are missing out on key yearly … – Belfast Telegraph


Belfast Telegraph

More than a million people suffering from asthma are missing out on key yearly
Belfast Telegraph
"With the worrying scale of prescribing errors identified by the National Review of Asthma Deaths, it's vital that doctors and nurses do everything they can to follow up with patients to review their medicines, especially as asthma can vary hugely over
Over A Million People Suffering From Asthma Aren't Receiving Yearly Checks Huffington Post UK
Asthma patients' lives 'at risk' by missing annual checksBBC News
Welsh asthma sufferers missing crucial checksITV News
Rochdale Online
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