Breathe Well Live Well
Condition: Severe Asthma
Intervention:
Sponsors: Academisch Medisch Centrum – Universiteit van Amsterdam (AMC-UvA); University Medical Center Groningen
Recruiting – verified November 2016
View full post on ClinicalTrials.gov: asthma | Studies received in the last 14 days
Condition: Idiopathic Angioedema
Interventions: Drug: Omalizumab; Drug: Placebos
Sponsors: University of Wisconsin, Madison; Novartis Pharmaceuticals
Not yet recruiting – verified November 2016
View full post on ClinicalTrials.gov: asthma | Studies received in the last 14 days
Condition: Sickle Cell Disease
Interventions: Drug: Azithromycin; Other: Placebo
Sponsor: Vanderbilt University
Recruiting – verified November 2016
View full post on ClinicalTrials.gov: asthma | Studies received in the last 14 days
| Related Articles |
A 12-week, Randomized, Parallel-Group, Proof-of-Concept Study of Tulobuterol Patch and Salmeterol Inhaler as Add-on Therapy in Adult-Onset Mild-to-Moderate Asthma.
Clin Exp Pharmacol Physiol. 2016 Oct 8;:
Authors: Inoue H, Niimi A, Matsumoto H, Ito I, Oguma T, Otsuka K, Takeda T, Nakaji H, Tajiri T, Iwata T, Nagasaki T, Mishima M
Abstract
Patch formulation of tulobuterol has been used in asthma treatment as a long-acting ?2 -agonist (LABA) through sustained skin absorption. Its treatment efficacy, especially in small airways, remains poorly understood. The study aim was to investigate LABA add-on effects of tulobuterol patch (TP) and salmeterol inhaler (SA) on pulmonary function, asthma control, and health status. Patients who had adult-onset under-controlled asthma, despite taking inhaled corticosteroids, were enrolled in a randomized, open-label, parallel-group, proof-of-concept study of 12-week add-on treatment with TP (n = 16) or SA (n = 17). Spirometry, impulse oscillometry (IOS), exhaled nitric oxide levels, and clinical questionnaires of asthma control, health status (St. George’s Respiratory Questionnaire: SGRQ), and symptoms were evaluated every 4 weeks. Add-on treatment of SA significantly improved the spirometric indices of small airway obstruction (forced expiratory flow between 25% and 75% of FVC: FEF25-75 , and maximum expiratory flow at 25% of FVC: MEF25 ) and IOS indices of whole respiratory resistance (resistance at 5 Hz) as compared to TP. In intra-group comparisons, add-on treatment of TP improved the scores of the asthma control test and the total SGRQ, as well as the symptom and impact components of the SGRQ. SA add-on treatment improved FEV1 and IOS parameters of resistance at 20 Hz and reactance at 5 Hz. Neither of the treatments improved exhaled nitric oxide levels. In conclusion, add-on treatment of TP improved asthma control and health status, whereas SA improved pulmonary function measures associated with large and small airway involvement among patients with adult-onset mild-to-moderate asthma. This article is protected by copyright. All rights reserved.
PMID: 27718262 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
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Related Articles |
Step 4: stick or twist? A review of asthma therapy.
BMJ Open Respir Res. 2016;3(1):e000143
Authors: Slater MG, Pavord ID, Shaw DE
Abstract
Many people with asthma do not achieve disease control, despite bronchodilators and inhaled corticosteroid therapy. People with uncontrolled asthma are at higher risk of an asthma attack and death, with mortality rates estimated at 1000 deaths/year in England and Wales. The recent National Review of Asthma Deaths (NRAD) report, ‘Why asthma still kills’, recommended that patients at step 4 or 5 of the British Thoracic Society/Scottish Intercollegiate Guidelines Network (BTS/SIGN) guidance must be referred to a specialist asthma service. This article reviews the 2014 evidence base for therapy of asthma patients at BTS/SIGN step 4 of the treatment cascade, in response to key findings of the NRAD report and lack of preferred treatment option at this step.
PMID: 27651907 [PubMed]
View full post on pubmed: asthma
Chandigarh Tribune |
Holistic therapy boon for asthma sufferers
Chandigarh Tribune Practising yoga could help asthma sufferers breathe more easily, a new study has found. The Cochrane Review — an international healthcare non-profit organisation — suggests yoga can improve the quality of life for people who suffer from asthma. |
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Novel gene therapy shows potential for lung repair in asthma
Science Daily In asthma, airways become inflamed, resulting in narrowing of these airways and debilitating symptoms that include coughing, wheezing, shortness of breath and chest tightness. Asthma and other respiratory diseases also cause changes in the large and … |
View full post on asthma – Google News
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Nanoparticle-based gene therapy may hold promise for patients with asthma
News-Medical.net A new study has demonstrated a way to deliver a nanoparticle-based gene therapy, in order to repair lungs damaged by chronic allergic asthma and to reduce inflammation that causes asthma attacks. The potential therapy, tested in mice, may hold promise … |
View full post on asthma – Google News
Western Daily Press |
New therapy could reduce asthma sufferers' lung inflammation
Western Daily Press Dr Adriana Lopes da Silva, of the Federal University of Rio de Janeiro in Brazil, said: "We found a single dose of highly compacted DNA nanoparticle thymulin gene therapy effectively reduces the inflammatory and remodeling process in asthmatic lungs. |
View full post on asthma – Google News
EurekAlert (press release) |
Novel gene therapy shows potential for lung repair in asthma American Thoracic Society
EurekAlert (press release) ATS 2016, SAN FRANCISCO — A new study has demonstrated a way to deliver a nanoparticle-based gene therapy, in order to repair lungs damaged by chronic allergic asthma and to reduce inflammation that causes asthma attacks. The potential therapy … |
View full post on asthma – Google News