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Spray Polyurethane Foam Alliance Urges Asthma Prevention Through Proper Building Insulation
Lung Disease News SFPAlogo The trade association Spray Polyurethane Foam Alliance (SPFA) is urging consumers, businesses, and builders in the U.S. to help prevent asthma and asthma-related attacks by using responsible building materials to lower rates of fossil fuel … |
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Mum says son who died after severe asthma attack will live on through others after his organs were donated
Manchester Evening News The mum of a teenage boy who died after suffering a severe asthma attack says her son will live on through others after his organs were donated. Thomas-Michael Martin, known as Tom, was on his way to hospital with mum Dawn Gerrard and a friend when … |
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Mesenchymal stem cells induce suppressive macrophages through phagocytosis in a mouse model of asthma.
Stem Cells. 2016 Feb 17;
Authors: Braza F, Dirou S, Forest V, Sauzeau V, Hassoun D, Chesné J, Cheminant-Muller MA, Sagan C, Magnan A, Lemarchand P
Abstract
Mesenchymal stem cell (MSC) immunosuppressive functions make them attractive candidates for anti-inflammatory therapy in allergic asthma. However the mechanisms by which they ensure therapeutic effects remain to be elucidated. In an acute mouse model of house dust mite (Der f)-induced asthma, one i.v. MSC injection was sufficient to normalize and stabilize lung function in Der f-sensitized mice as compared to control mice. MSC injection decreased in vivo airway responsiveness and decreased ex vivo carbachol-induced bronchial contraction, maintaining bronchial expression of the inhibitory type 2 muscarinic receptor. To evaluate in vivo MSC survival, MSCs were labelled with PKH26 fluorescent marker prior to i.v. injection, and 1 to 10 days later total lungs were digested to obtain single-cell suspensions. 91.5?±?2.3% and 86.6?±?6.3% of the recovered PKH26(+) lung cells expressed specific macrophage markers in control and Der f mice respectively, suggesting that macrophages had phagocyted in vivo the injected MSCs. Interestingly, only PKH26(+) macrophages expressed M2 phenotype, while the innate PKH26(-) macrophages expressed M1 phenotype. Finally, the remaining 0.5% PKH26(+) MSCs expressed 10 to 100 fold more COX-2 than before injection, suggesting in vivo MSC phenotype modification. Together, the results of this study indicate that MSCs attenuate asthma by being phagocyted by lung macrophages, which in turn acquire a M2 suppressive phenotype. This article is protected by copyright. All rights reserved.
PMID: 26891455 [PubMed – as supplied by publisher]
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Pediatric, community hospitals see significant long-term improvements through …
Healio Implementation of an evidence-based care process model for pediatric patients with asthma helped to reduce readmissions, costs and length of stay at a primary children's hospital and seven other community hospitals while also maintaining current … |
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Asthma is easily manageable through strict control measures: Doctors
Daily News Egypt Asthma is the most common chronic inflammatory disease of the airways. It is a condition in which the airways narrow and swell and then produce extra mucus. This can make breathing difficult and trigger coughing, wheezing, and shortness of breath, … |
View full post on asthma – Google News