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NObreath®: the essential tool for World Asthma Day
News-Medical.net This year, apprehensions have been rising about asthma after recent studies uncovered some horrific truths about asthma; Asthma UK found that over 120,000 asthma sufferers in the UK are at risk from wrongly prescribed medication, whilst NICE published … |
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Use capnography as a primary assessment tool for asthma and COPD exacerbation
EMS1.com Asthma, bronchiectasis, emphysema, chronic bronchitis and cystic fibrosis all fall within the obstructive lung disease spectrum. Of these, asthma is the most common chronic disease among children, and asthma affects nearly 235 million people of all … |
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A short review on structure and role of cyclic-3′,5′-adenosine monophosphate-specific phosphodiesterase 4 as a treatment tool.
J Res Pharm Pract. 2015 Oct-Dec;4(4):175-181
Authors: Eskandari N, Mirmosayyeb O, Bordbari G, Bastan R, Yousefi Z, Andalib A
Abstract
Cyclic nucleotide phosphodiesterases (PDEs) are known as a super-family of enzymes which catalyze the metabolism of the intracellular cyclic nucleotides, cyclic-3′,5′-adenosine monophosphate (cAMP), and cyclic-3′,5′-guanosine monophosphate that are expressed in a variety of cell types that can exert various functions based on their cells distribution. The PDE4 family has been the focus of vast research efforts over recent years because this family is considered as a prime target for therapeutic intervention in a number of inflammatory diseases such as asthma, chronic obstructive pulmonary disease, and rheumatoid arthritis, and it should be used and researched by pharmacists. This is because the major isoform of PDE that regulates inflammatory cell activity is the cAMP-specific PDE, PDE4. This review discusses the relationship between PDE4 and its inhibitor drugs based on structures, cells distribution, and pharmacological properties of PDE4 which can be informative for all pharmacy specialists.
PMID: 26645022 [PubMed – as supplied by publisher]
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Tracking tool predicts asthma control deterioration in children 1 week ahead
Healio An estimated 7.1 million American children have pediatric asthma, translating to $9.3 billion in annual total direct health care costs. Suboptimal asthma control in children leads to frequent asthma exacerbations, which increase health care costs and … |
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Comprehensive FISH Probe Design Tool Applied to Imaging Human Immunoglobulin Class Switch Recombination.
PLoS One. 2012;7(12):e51675
Authors: Nedbal J, Hobson PS, Fear DJ, Heintzmann R, Gould HJ
Abstract
We present a web engine boosted fluorescence in-situ hybridization (webFISH) algorithm using a genome-wide sequence similarity search to design target-specific single-copy and repetitive DNA FISH probes. The webFISH algorithm featuring a user-friendly interface (http://www.webfish2.org/) maximizes the coverage of the examined sequences with FISH probes by considering locally repetitive sequences absent from the remainder of the genome. The highly repetitive human immunoglobulin heavy chain sequence was analyzed using webFISH to design three sets of FISH probes. These allowed direct simultaneous detection of class switch recombination in both immunoglobulin-heavy chain alleles in single cells from a population of cultured primary B cells. It directly demonstrated asynchrony of the class switch recombination in the two alleles in structurally preserved nuclei while permitting parallel readout of protein expression by immunofluorescence staining. This novel technique offers the possibility of gaining unprecedented insight into the molecular mechanisms involved in class switch recombination.
PMID: 23272136 [PubMed – in process]
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On-off pulsed oral drug-delivery systems: a possible tool for drug delivery in chronotherapy.
Ther Deliv. 2011 Sep;2(9):1199-214
Authors: Tran TH, Lee BJ
Abstract
Circadian rhythms regulate most body functions and are important factors to consider when administering drugs. The existence of circadian rhythms in nature and their influences on human biological systems have given rise to the concept of chronotherapy, which is the science of delivering drugs in a synchronized manner with the rhythm-dependent circadian variation inherent in the human body. The safety and efficacy of a drug can be improved by matching the peak plasma concentration during a 24 h period of the rhythms. An on-off pulsed (pulsatile or time-controlled) release drug-delivery system offers rapid and transient release; stepwise release; and the sustained release of a certain amount of drug within a short time period after a predetermined off-release period according to the circadian rhythm of disease states. These systems deliver the drug at the right time and at an appropriate dosage and are the best approach for chronotherapy. These systems show promise for the optimal therapy of chronic diseases such as asthma, hypertension, myocardial infarction and arthritis, which show a circadian dependency. Various technologies have been adopted to mimic circadian rhythms in physiological functions and diseases. This review focuses on the basic concept of circadian rhythm, chronotherapy and recent advances in the development of on-off pulsed oral drug-delivery systems for optimal therapy.
PMID: 22833913 [PubMed – in process]
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Simple diagnostic tool for asthma,COPD remains unknown: Survey
Indian Express Spirometry, a dignostic tool for asthma and chronic obstructive pulmonary disease (COPD) remains poorly utilised in clinical practice, with few people having … Lung Disease: Leading Health Concern in Ontario Often … Are your lungs in good shape? Free tests will determine lung function |
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Web-based Tool Helps Children with Asthma
Biomed Middle East Asthma is the most common chronic illness in adolescents and children in the United States. The burden of asthma on children is substantial: kids with asthma … Doctor to assess mine dust impact on children |
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Web-based tool helps parents improve on kids' asthma treatment
Medical Xpress Asthma is the most common chronic illness in adolescents and children, affecting an estimated seven million children up to the age of 17 in the United States. The burden of asthma on children is substantial: kids with asthma have a three-fold greater … |
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Web-Based Tool Helps Parents Improve on Kids' Asthma Treatment
Newswise (press release) Newswise — SEATTLE: June 13, 2012 — Asthma is the most common chronic illness in adolescents and children, affecting an estimated seven million children up to the age of 17 in the United States. The burden of asthma on children is substantial: kids … Children with asthma marginalized in movies, researcher says |
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