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New asthma treatment
WTAJ Imagine struggling to fill your lungs with air and with each breath, feeling like you're suffocating. That's what happens to more than 18-million Americans who suffer from asthma. Medications, shots, inhalers and steroids help most people keep it under … |
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Leukotriene-Receptor Antagonists Versus Placebo in the Treatment of Asthma in Adults and Adolescents: A Systematic Review and Meta-Analysis.
Ann Intern Med. 2015 Sep 22;
Authors: Miligkos M, Bannuru RR, Alkofide H, Kher SR, Schmid CH, Balk EM
Abstract
Background: Leukotriene-receptor antagonists (LTRAs) are recommended as an alternative treatment in patients with mild asthma, but their effect compared with placebo is unclear.
Purpose: To determine the benefits and harms of LTRAs as monotherapy or in combination with inhaled corticosteroids compared with placebo in adults and adolescents with asthma.
Data Sources: MEDLINE and the Cochrane Central Register of Controlled Trials from inception through June 2015.
Study Selection: Peer-reviewed, English-language, randomized, controlled trials in patients with asthma that reported the effect of LTRAs versus placebo on measures of asthma control.
Data Extraction: Three researchers extracted data on study population, interventions, outcome measures, and adverse events. One researcher assessed risk of bias.
Data Synthesis: Of the 2008 abstracts that were screened, 50 trials met eligibility criteria. Random-effects meta-analyses of 6 trials of LTRA monotherapy showed that LTRAs reduced the risk for an exacerbation (summary risk ratio [RR], 0.60 [95% CI, 0.44 to 0.81]). In 4 trials of LTRAs as add-on therapy to inhaled corticosteroids, the summary RR for exacerbation was 0.80 (CI, 0.60 to 1.07). Leukotriene-receptor antagonists either as monotherapy or add-on therapy to inhaled corticosteroids increased FEV1, whereas FEV1 percentage of predicted values was only improved in trials of LTRA monotherapy. Adverse event rates were similar in the intervention and comparator groups.
Limitation: Variation in definitions and reporting of outcomes, high risk of bias in some studies, heterogeneity of findings, possible selective outcome reporting bias, and inability to assess the effect of asthma severity on summary estimates.
Conclusion: Leukotriene-receptor antagonists as monotherapy improved asthma control compared with placebo, but which patients are most likely to respond to treatment with LTRAs remains unclear.
Primary Funding Source: National Institutes of Health.
PMID: 26390230 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
Condition: Asthma
Interventions: Drug: QAW039; Drug: QAW039; Drug: Placebo
Sponsor: Novartis Pharmaceuticals
Not yet recruiting – verified July 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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FDA expands indication of BI inhaler to include maintenance treatment of asthma
FierceDrugDelivery The only inhaler that administers a slow-moving mist to help respiratory patients inhale the medication is now FDA-approved for the long-term maintenance treatment of asthma, in addition to its previous indication to treat COPD. The expanded indication … FDA Approves New Indication for Boehringer's Spiriva Respimat Landmark year for Boehringer Ingelheim's respiratory portfolio – new data for … ERS 2015: Landmark year for Boehringer Ingelheim's respiratory portfolio – new … |
View full post on asthma – Google News
Condition: Asthma
Interventions: Drug: QMF149; Drug: QMF149; Drug: MF 400; Drug: MF 400; Drug: salmeterol /fluticasone
Sponsor: Novartis Pharmaceuticals
Not yet recruiting – verified September 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
KTAL |
Unique new treatment approach is showing results for children with asthma
KTAL Data from 35,000 adolescent parent pairs showed teens were three times more likely to smoke and nearly twice as likely to become dependent on nicotine when their parent was a smoker. Daughters were especially vulnerable to their mother's smoking … |
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Global Asthma Treatment Market: North America expected to dominate the global …
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3News NZ |
Allergy Study Could Lead To Asthma Prevention Treatment
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View full post on asthma – Google News