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The genus Peucedanum traditional Uses, phytochemistry and Pharmacological Properties: A Review.

J Ethnopharmacol. 2014 Sep 2;

Authors: Sarkhail P

Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: The genus Peucedanum (Apiaceae) comprising more than 120 species are widely distributed in Europe, Asia and Africa. The ethnopharmacologial history of this genus indicated that some extracts of aerial and underground parts of several Peucedanum species have used in folk medicine for treatment of various conditions, such as cough, cramps, pain, rheumatism, asthma and angina.
AIM OF THE REVIEW: This review focuses on ethnopharmacological uses of Peucedanum species, as well as the phytochemical, pharmacological and toxicological studies on this genus. Through this review, we intend to highlight the known and potential effects of the Peucedanum species or their isolated compounds and show which of traditional medicine uses have supported by pharmacological investigations.
METHODS: Information on the Peucedanum species collected from scientific journals, books, thesis and reports via a library and electronic search (using Google Scholar, Pubmed, Scopus, Web of Science and ScienceDirect). This review covers the available literature from 1970 to the end of September 2013.
RESULTS: Although, there are about 120 species in this genus, so far many species that have received no or little attention and the most of pharmacological studies were performed just about 20 species. Many phytochemical investigations on this genus confirmed Peucedanum species are rich in essential oils and coumarins. The present review article shows Peucedanum species have a wide spectrum of pharmacological activities that the most reported activities of Peucedanum plants come back to the presence of coumarins, flavonoids, phenolics and essential oils CONCLUSIONS: The present review confirmed some Peucedanum species have emerged as a good source of the traditional medicine for treatment of inflammation, microbial infections, cardiopulmonary diseases and provides new insights for further investigations on isolated compounds specially on praeruptorins to find novel therapeutics and drug discovery. However, for uses of Peucedanum species to prevent and treat various diseases the additional pharmacological studies to find the mechanism of action, safety and efficacy of them before starting clinical trials are required.

PMID: 25193684 [PubMed – as supplied by publisher]

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