Condition: Bronchial Asthma
Intervention: Drug: budesonide 160?g/formoterol 4.5?g
Sponsor: Zhujiang Hospital
Recruiting – verified July 2016
View full post on ClinicalTrials.gov: asthma | Studies received in the last 14 days
Childhood asthma genetic variant can be neutralized, say scientists – Doctor Tipster
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Childhood asthma genetic variant can be neutralized, say scientists
Doctor Tipster A new study from the Ludwig-Maximilians-Universitaet (LMU) has discovered that the effect of a genetic variant that increases the likelihood of having childhood asthma can be neutralized. The study was also able to show that young infants are … |
View full post on asthma – Google News
Asthmatic Kids With Gene Variant May Not Benefit From Inhaler Drugs; British … – Medical Daily
Medical Daily |
Asthmatic Kids With Gene Variant May Not Benefit From Inhaler Drugs; British …
Medical Daily Such controller and emergency inhalers are often the primary treatment for asthma in children and adults around the world, with 9.3 percent of American children suffering the respiratory disease, according to the Centers for Disease Control and Prevention. |
View full post on asthma – Google News
The Effect of Bronchodilator on Eosinophilic Bronchitis and Cough Variant Asthma
Conditions: Eosinophilic Bronchitis; Cough Variant Asthma
Intervention: Drug: Bambuterol Hydrochloride tablets
Sponsor: The First Affiliated Hospital of Guangzhou Medical University
Recruiting – verified December 2013
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
A new regulatory variant in the interleukin-6 receptor gene associates with asthma risk.
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Related Articles |
A new regulatory variant in the interleukin-6 receptor gene associates with asthma risk.
Genes Immun. 2013 Aug 15;
Authors: Revez JA, Bain L, Chapman B, Powell JE, Jansen R, Duffy DL, Tung JY, AAGC Collaborators, Matheson MC, Marks GB, Hui J, Le Souëf P, Danoy P, Baltic S, Nyholt DR, Jenkins M, Hayden C, Beilby J, Cheah F, Madden PA, Heath AC, Hopper JL, Musk B, Leeder SR, Walters EH, James A, Jones G, Abramson MJ, Robertson CF, Dharmage SC, Brown MA, Thompson PJ, Penninx BW, Visscher PM, De Geus EJ, Boomsma DI, Hinds DA, Martin NG, Montgomery GW, Ferreira MA
Abstract
The main genetic determinant of soluble interleukin 6 receptor (sIL-6R) levels is the missense variant rs2228145 that maps to the cleavage site of IL-6R. For each Ala allele, sIL-6R serum levels increase by ?20?ng?ml(-1) and asthma risk by 1.09-fold. However, this variant does not explain the total heritability for sIL-6R levels. Additional independent variants in IL6R may therefore contribute to variation in sIL-6R levels and influence asthma risk. We imputed 471 variants in IL6R and tested these for association with sIL-6R serum levels in 360 individuals. An intronic variant (rs12083537) was associated with sIL-6R levels independently of rs4129267 (P=0.0005), a proxy single-nucleotide polymorphism for rs2228145. A significant and consistent association for rs12083537 was observed in a replication panel of 354 individuals (P=0.033). Each rs12083537:A allele increased sIL-6R serum levels by 2.4?ng?ml(-1). Analysis of mRNA levels in two cohorts did not identify significant associations between rs12083537 and IL6R transcription levels. On the other hand, results from 16?705 asthmatics and 30?809 controls showed that the rs12083537:A allele increased asthma risk by 1.04-fold (P=0.0419). Genetic risk scores based on IL6R regulatory variants may prove useful in explaining variation in clinical response to tocilizumab, an anti-IL-6R monoclonal antibody.Genes and Immunity advance online publication, 15 August 2013; doi:10.1038/gene.2013.38.
PMID: 23945879 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
Genetic Variant Increases Asthma Risk in Children With Human Rhinovirus – Monthly Prescribing Reference
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Genetic Variant Increases Asthma Risk in Children With Human Rhinovirus
Monthly Prescribing Reference Minal Caliskan, from University of Chicago, and colleagues genotyped the 17q21 locus. Associations between asthma and HRV and respiratory syncytial virus (RSV) wheezing illness were assessed. Both unstimulated and HRV-stimulated peripheral-blood … |
View full post on asthma – Google News
CD44 variant isoforms are specifically expressed on peripheral blood lymphocytes from asthmatic patients.
CD44 variant isoforms are specifically expressed on peripheral blood lymphocytes from asthmatic patients.
Exp Ther Med. 2012 Jul;4(1):79-83
Authors: Yang C, Liang H, Zhao H, Jiang X
Abstract
Asthma is a disease characterized by chronic airway inflammation, and Th2 cells play a critical role in initiating and sustaining asthmatic inflammation. It has been shown that CD44 expressed on CD4(+) T cells plays a critical role in the accumulation of antigen-specific Th2 cells in the development of airway hyperresponsiveness induced by antigen challenge in the airways. The aim of this study was to determine whether there are specific CD44 variant isoforms (CD44v) expressed on lymphocytes from asthmatic patients. We collected whole blood samples from 103 normal subjects, 165 subjects with asthma and 104 with pneumonia. Peripheral blood lymphocyte isolation was performed, and total RNA was extracted from the isolated lymphocytes, using nested PCR for specific CD44v amplification on lymphocytes. Demographic variables were analyzed using linear regression in order to determine whether the expression of CD44v was correlated with these demographic features. The nested PCR results revealed that CD44v5 was expressed by 55.2% of asthma patients, which was significantly higher than levels of expression in the other groups. Lower percentages of individuals in the normal subject group exhibited expression of CD44v5 and CD44v6. The data demonstrated that the percentage of individuals in the pneumonia group expressing CD44v5 was 29.0%, but a higher percentage of these patients expressed CD44v6. CD44v5 expression was positively correlated with IgE levels (p=0.032) in the asthmatic patient group, and CD44v6 was significantly positively correlated with the neutrophil count (p<0.05). CD44v5 was expressed by a higher proportion of asthmatic patients than other subjects and thus may play an important role in the pathogenesis of asthma. These findings may offer a new target for the diagnosis and treatment of asthma and may also provide insights into the mechanisms of asthma development.
PMID: 23060926 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
Gene Variant Linked to Failure of Asthma Drug (HealthDay)
HealthDay – WEDNESDAY, Sept. 28 (HealthDay News) — About one in six asthma
sufferers carries a genetic variant that’s associated with a poor response
to commonly prescribed inhaled asthma medications called corticosteroids,
according to a new study.
View full post on Yahoo! News: Health News
Asthma Drugs Connected To Gene Variant Response – ThirdAge
 ThirdAge |
Asthma Drugs Connected To Gene Variant Response
ThirdAge A teenage girl using an inhaler for her asthma. A new study has found asthma-like symptoms are more likely to be display… Read Moreed by teenagers whose mothers were overweight or obese before becoming pregnant with them. Asthma drugs are sometimes … Gene Variant and Asthma Link Discovered by Researchers |
View full post on asthma – Google News
Gene Variant Linked to Failure of Asthma Drug – Doctors Lounge
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Gene Variant Linked to Failure of Asthma Drug
Doctors Lounge 28 (HealthDay News) — About one in six asthma sufferers carries a genetic variant that's associated with a poor response to commonly prescribed inhaled asthma medications called corticosteroids, according to a new study. Researchers found that people … |
View full post on asthma – Google News