Back-to-school asthma attacks linked to common cold virus in children – Medical News Today


Medical News Today

Back-to-school asthma attacks linked to common cold virus in children
Medical News Today
Children with asthma are most likely to experience an attack at the start of the school year and after long breaks, and exacerbations appear to be linked to the common cold virus. These are the findings from research published in Proceedings of the
Study Ties School Calendar to Asthma Flare-Up…WebMD
Common Colds at School a Primary Driver of Asthma Hospitalizations for ChildrenUT News | The University of Texas at Austin
Cold viruses at school largely to blame for asthma hospitalizationsNews-Medical.net
MyStatesman.com
all 16 news articles »

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A systems approach to understanding human rhinovirus and influenza virus infection.

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A systems approach to understanding human rhinovirus and influenza virus infection.

Virology. 2015 Oct 1;486:146-157

Authors: Kim TK, Bheda-Malge A, Lin Y, Sreekrishna K, Adams R, Robinson MK, Bascom CC, Tiesman JP, Isfort RJ, Gelinas R

Abstract
Human rhinovirus and influenza virus infections of the upper airway lead to colds and the flu and can trigger exacerbations of lower airway diseases including asthma and chronic obstructive pulmonary disease. Novel diagnostic and therapeutic targets are still needed to differentiate between the cold and the flu, since the clinical course of influenza can be severe while that of rhinovirus is usually more mild. In our investigation of influenza and rhinovirus infection of human respiratory epithelial cells, we used a systems approach to identify the temporally changing patterns of host gene expression from these viruses. After infection of human bronchial epithelial cells (BEAS-2B) with rhinovirus, influenza virus or co-infection with both viruses, we studied the time-course of host gene expression changes over three days. We modeled host responses to these viral infections with time and documented the qualitative and quantitative differences in innate immune activation and regulation.

PMID: 26437235 [PubMed – as supplied by publisher]

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NIH-Funded Scientists Identify Receptor for Asthma-Associated Virus – Infection Control Today

NIH-Funded Scientists Identify Receptor for Asthma-Associated Virus
Infection Control Today
Scientists funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have identified a cellular receptor for rhinovirus C, a cold-causing virus that is strongly associated with severe asthma

and more »

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Scientists Identify Receptor for Asthma Associated Virus – Drug Discovery & Development

Scientists Identify Receptor for Asthma Associated Virus
Drug Discovery & Development
Scientists funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have identified a cellular receptor for rhinovirus C, a cold-causing virus that is strongly associated with severe asthma

and more »

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Docs Offer Advice for Combating Respiratory Virus That’s Striking Kids – Philly.com


New York Times

Docs Offer Advice for Combating Respiratory Virus That's Striking Kids
Philly.com
"Children with pre-existing lung conditions, such as asthma, appear to be at the greatest risk for severe symptoms from this virus. Most EV-D68 infected children recover without serious illness," Dr. Albert Rizzo, senior medical advisor at the American
San Juan County hit by first case of D68 enterovirusJournal of the San Juan Islands
Ontario County confirms adult case of Enterovirus D68News 10NBC
Ontario County adult has confirmed case of enterovirus (EV-D68)WebsterPost.com
The Redding Pilot –The Journal News | LoHud.com
all 1,215 news articles »

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Exacerbation of asthma and airway infection: is the virus the villain?

Exacerbation of asthma and airway infection: is the virus the villain?

J Pediatr (Rio J). 2014 Sep 24;

Authors: Costa LD, Costa PS, Camargos PA

Abstract
OBJECTIVE: to review the available literature on the association between acute viral respiratory tract infection and the onset of asthma exacerbations, identifying the most prevalent viruses, detection methods, as well as preventive and therapeutic aspects.
DATA SOURCE: a search was conducted in PubMed, Lilacs, and SciELO databases, between the years 2002 and 2013, using the following descriptors: asthma exacerbation, virus, child, and acute respiratory infection.
DATA SYNTHESIS: a total of 42 original articles addressing the identification of respiratory viruses during episodes of asthma exacerbation were selected, mostly cross-sectional studies. There was a wide variation in the methodology of the assessed studies, particularly in relation to the children’s age and methods of collection and viral detection. The results indicate that, in up to 92.2% of exacerbations, a viral agent was potentially the main triggering factor, and human rhinovirus was the most frequently identified factor. The pattern of viral circulation may have been responsible for the seasonality of exacerbations. The association between viral infections and allergic inflammation appears to be crucial for the clinical and functional uncontrolled asthma, but few studies have evaluated other triggering factors in association with viral infection.
CONCLUSIONS: respiratory viruses are present in the majority of asthmatic children during episodes of exacerbation. The involved physiopathological mechanisms are yet to be fully established, and the synergism between allergic inflammation and viral infection appears to determine uncontrolled disease. The role of other triggering and protective agents is yet to be clearly determined.

PMID: 25261603 [PubMed – as supplied by publisher]

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Caesarean Section and Hospitalization for Respiratory Syncytial Virus Infection: A Population Based Study.

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Caesarean Section and Hospitalization for Respiratory Syncytial Virus Infection: A Population Based Study.

Pediatr Infect Dis J. 2014 Sep 17;

Authors: Kristensen K, Fisker N, Haerskjold A, Ravn H, Simões EA, Stensballe L

Abstract
BACKGROUND AND OBJECTIVE:: Hospitalization for respiratory syncytial virus (RSV) infection and asthma share common determinants, and meta-analyses indicate that children delivered by caesarean section (CS) are at increased risk of asthma. We aimed to investigate whether birth by CS is associated with an increased risk of hospitalization for RSV illness.
METHODS:: This was a population based national register based cohort study, conducted between January 1997 and June 2003, that included all children born in Denmark and all hospitalizations for RSV disease in them from 0 – 23 months of age. We used Cox regression with adjustment for prematurity, asphyxia, birth weight, multiple births, single parenthood, maternal smoking during pregnancy, older siblings, and asthma diagnoses up to 2 weeks before hospitalization for RSV infection, to compare the effects of acute or elective CS versus vaginal delivery, on subsequent hospitalization for RSV disease. A test for homogeneity was used to assess for effect over time.
RESULTS:: 399,175 children with 10,758 hospitalizations for RSV illness were included. 31,715 were born by acute CS and 30,965 by elective CS. Adjusted hazard ratios for hospitalization for RSV infection in children born by acute CS and by elective CS were 1.09 (1.01 – 1.17) and 1.27 (1.19 – 1.36), respectively. The effect of elective CS remained unchanged throughout the first two years of life (p = 0.53), whereas the effect of acute CS was only present in the second year of life (p = 0.001).
CONCLUSION:: Delivery by caesarian section is associated with an increased risk of hospitalization for RSV infeciton. This effect continues at least throughout the first two years of life.

PMID: 25232778 [PubMed – as supplied by publisher]

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