Iron Status is Associated with Asthma and Lung Function in US Women.

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Iron Status is Associated with Asthma and Lung Function in US Women.

PLoS One. 2015;10(2):e0117545

Authors: Brigham EP, McCormack MC, Takemoto CM, Matsui EC

Abstract
BACKGROUND: Asthma and iron deficiency are common conditions. Whether iron status affects the risk of asthma is unclear.
OBJECTIVE: To determine the relationship between iron status and asthma, lung function, and pulmonary inflammation.
METHODS: Relationships between measures of iron status (serum ferritin, serum soluble transferrin receptor (sTfR), and sTfR/log10ferritin (sTfR-F Index)) and asthma, lung function, and pulmonary inflammation were examined in women 20-49 years in the National Health and Nutrition Examination Survey. Logistic, linear, and quadratic regression models accounting for the survey design of NHANES were used to evaluate associations between iron status and asthma-related outcomes and were adjusted for race/ethnicity, age, smoking status, income, and BMI.
RESULTS: Approximately 16% reported a lifetime history of asthma, 9% reported current asthma, and 5% reported a recent asthma episode/attack (n = 2906). Increased ferritin (iron stores) was associated with decreased odds of lifetime asthma, current asthma, and asthma attacks/episodes in the range of ferritin linearly correlated with iron stores (20-300ng/ml). The highest quintile of ferritin (>76 ng/ml) was also associated with a decreased odds of asthma. Ferritin levels were not associated with FEV1. Increased values of the sTfR-F Index and sTfR, indicating lower body iron and higher tissue iron need, respectively, were associated with decreased FEV1, but neither was associated with asthma. None of the iron indices were associated with FeNO.
CONCLUSION: In US women, higher iron stores were inversely associated with asthma and lower body iron and higher tissue iron need were associated with lower lung function. Together, these findings suggest that iron status may play a role in asthma and lung function in US women.

PMID: 25689633 [PubMed – as supplied by publisher]

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Treatment of acute asthma among pregnant women improves over 17-year period – Healio

Treatment of acute asthma among pregnant women improves over 17-year period
Healio
“On the basis of four observational studies of pregnant women with acute asthma in 48 EDs, we found a significant increase in the ED administration of systemic corticosteroids and prescription of systemic corticosteroids at ED discharge over the 17

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Improved Management of Acute Asthma among Pregnant Women Presenting to the Emergency Department.

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Improved Management of Acute Asthma among Pregnant Women Presenting to the Emergency Department.

Chest. 2014 Oct 30;

Authors: Hasegawa K, Cydulka RK, Sullivan AF, Langdorf MI, Nonas SA, Nowak RM, Wang NE, Camargo CA

Abstract
Abstract: Background:A multicenter study in the late 1990s demonstrated suboptimal emergency asthma care for pregnant women in US emergency departments (EDs). After a decade, follow-up data are lacking. We aimed to examine changes in emergency asthma care of pregnant women since the 1990s. Methods:We combined data from four multicenter observational studies of ED patients with acute asthma performed in 1996-2001 (three studies), and 2011-2012 (one study). We restricted the data so that comparisons were based on the same 48 EDs in both time periods. We identified all pregnant patients aged 18 to 44 years with acute asthma. Primary outcomes were treatment with systemic corticosteroids in the ED, and, among those sent home, at ED discharge. Results:Of 4895 ED patients with acute asthma, the analytic cohort comprised 125 pregnant women. Over the two time periods, there were no significant changes in patient demographics, chronic asthma severity, or initial peak expiratory flow. In contrast, ED systemic corticosteroids treatment increased significantly from 51% to 78% across the time periods (OR 3.11; 95%CI 1.27-7.60; P=0.01); systemic corticosteroids at discharge increased from 42% to 63% (OR 2.49; 95%CI 0.97-6.37; P=0.054). In the adjusted analyses, pregnant women in recent years were more likely to receive systemic corticosteroids, both in ED (OR 4.76; 95%CI 1.63-13.9; P=0.004) and at discharge (OR 3.18; 95%CI 1.05-9.61; P=0.04). Conclusions:Over the two time periods, emergency asthma care in pregnant women has significantly improved. However, with one in three pregnant women being discharged home without systemic corticosteroids, further improvement is warranted.
Background: A multicenter study in the late 1990s demonstrated suboptimal emergency asthma care for pregnant women in US emergency departments (EDs). After a decade, follow-up data are lacking. We aimed to examine changes in emergency asthma care of pregnant women since the 1990s.
Methods: We combined data from four multicenter observational studies of ED patients with acute asthma performed in 1996-2001 (three studies), and 2011-2012 (one study). We restricted the data so that comparisons were based on the same 48 EDs in both time periods. We identified all pregnant patients aged 18 to 44 years with acute asthma. Primary outcomes were treatment with systemic corticosteroids in the ED, and, among those sent home, at ED discharge.
Results: Of 4895 ED patients with acute asthma, the analytic cohort comprised 125 pregnant women. Over the two time periods, there were no significant changes in patient demographics, chronic asthma severity, or initial peak expiratory flow. In contrast, ED systemic corticosteroids treatment increased significantly from 51% to 78% across the time periods (OR 3.11; 95%CI 1.27-7.60; P=0.01); systemic corticosteroids at discharge increased from 42% to 63% (OR 2.49; 95%CI 0.97-6.37; P=0.054). In the adjusted analyses, pregnant women in recent years were more likely to receive systemic corticosteroids, both in ED (OR 4.76; 95%CI 1.63-13.9; P=0.004) and at discharge (OR 3.18; 95%CI 1.05-9.61; P=0.04).
Conclusions: Over the two time periods, emergency asthma care in pregnant women has significantly improved. However, with one in three pregnant women being discharged home without systemic corticosteroids, further improvement is warranted.

PMID: 25358070 [PubMed – as supplied by publisher]

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Ambient Air Pollution Exposure and Incident Adult Asthma in a Nationwide Cohort of US Women.

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Ambient Air Pollution Exposure and Incident Adult Asthma in a Nationwide Cohort of US Women.

Am J Respir Crit Care Med. 2014 Aug 29;

Authors: Young MT, Sandler DP, DeRoo LA, Vedal S, Kaufman JD, London SJ

Abstract
Rationale: Limited prior data suggests an association between traffic-related air pollution and incident asthma in adults. No published studies assess the effect of long-term exposures to particulate matter less than 2.5 µm in diameter (PM2.5) on adult incident asthma. Objectives: To estimate the association between ambient air pollution exposures (PM2.5 and nitrogen dioxide, NO2) and development of asthma and incident respiratory symptoms. Methods: The Sister Study is a US cohort study of risk factors for breast cancer and other health outcomes (n=50,884) in sisters of women with breast cancer (enrollment: 2003-2009). Annual average (2006) ambient PM2.5 and NO2 concentrations were estimated at participants’ addresses using a national land-use/kriging model incorporating roadway information. Outcomes at follow-up (2008-2012) included incident self-reported wheeze, chronic cough, and doctor-diagnosed asthma in women without baseline symptoms. Measures and Main Results: Adjusted analyses included 254 incident cases of asthma, 1,023 of wheeze, and 1,559 of chronic cough. For an interquartile range (IQR) difference (3.6 µg/m3) in estimated PM2.5 exposure, the adjusted odds-ratio (aOR) was 1.20 (95% CI=0.99-1.46, P=0.063) for incident asthma and 1.14 (95% CI=1.04-1.26, P=0.008) for incident wheeze. For NO2, there was evidence for an association with incident wheeze (aOR=1.08, 95% CI=1.00-1.17, P=0.048 per IQR of 5.8 ppb). Neither pollutant was significantly associated with incident cough (PM2.5: aOR=0.95, 95% CI=0.88-1.03, P=0.194, NO2: aOR=1.00, 95% CI=0.93-1.07, P=0.939). Conclusions: Results suggest that PM2.5 exposure increases the risk of developing asthma and PM2.5 and NO2 increase the risk of developing wheeze, the cardinal symptom of asthma, in adult women.

PMID: 25172226 [PubMed – as supplied by publisher]

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Asthma mortality rate highest in older women – Clinical Advisor


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Asthma mortality rate highest in older women
Clinical Advisor
An increased risk of osteoporosis, glaucoma, cataracts, and adrenal suppression in older women using inhalers; an increased rate of depression and more severe depression with severe asthma; and a diminished awareness of breathlessness are common …
Asthma Outcomes Worse in Older WomenHCPLive
Take control, asthma sufferers urgedWorld First Travel Insurance
Asthmatics 'don't know they are in danger'Independent Online
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Asthma outcomes worse in older women – Medical Xpress


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Asthma outcomes worse in older women
Medical Xpress
The researchers cite that the asthma rate is no greater in older women than in other segments of the population, but the rates of illness and death are much higher, with an asthma mortality rate that is four times higher among women older than 65 years
Take control, asthma sufferers urgedWorld First Travel Insurance

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ACAAI offers practical solutions to improve asthma problem in older women – News-Medical.net

ACAAI offers practical solutions to improve asthma problem in older women
News-Medical.net
Women over the age of 65 face numerous barriers to good health: an increased risk for obesity, greater struggles against poverty and higher rates of asthma with worse health outcomes. An article published in the August issue of Annals of Allergy
New action plan to help keep asthma sufferers out of 'yellow zone'Daily Digest

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Older Women With Asthma Face Worse Health Outcomes – U.S. News & World Report


Medical Daily

Older Women With Asthma Face Worse Health Outcomes
U.S. News & World Report
FRIDAY, Aug. 1, 2014 (HealthDay News) — Although older women with asthma often have worse health outcomes, they may not make asthma care a priority, according to a new study. "There is no doubt that women over 65 suffer from asthma much more than …
Female Baby Boomers With Asthma May Also Face Problems With Menopause Medical Daily
Staying Out of Asthma's Danger ZonedailyRx
Female baby boomers with asthma? You may need helpScience Codex
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Older Women With Asthma Face Worse Health Outcomes – HealthDay

Older Women With Asthma Face Worse Health Outcomes
HealthDay
FRIDAY, Aug. 1, 2014 (HealthDay News) — Although older women with asthma often have worse health outcomes, they may not make asthma care a priority, according to a new study. "There is no doubt that women over 65 suffer from asthma much more than …
Female baby boomers with asthma? You may need helpScience Codex
New Guidelines for Controlling Asthma in Older WomendailyRx
New Guidelines Help Keep Asthma Out of "Yellow Zone"Newswise (press release)
News-Medical.net
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