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Distinct Selectivity of Gangliosides Required for CD4(+) T and CD8(+) T Cell Activation.
Biochim Biophys Acta. 2014 Sep 2;
Authors: Inokuchi JI, Nagafuku M, Ohno I, Suzuki A
Abstract
T cells compose a crucial part of the immune system and require activation. The first step of T cell activation is triggered by the movement of one of their surface molecules, known as T cell receptor, into localized regions of cell membrane known as lipid rafts. Molecules called gangliosides are known to be major components of lipid rafts, but their role in T-cell activation remains to be elucidated. This review summarizes recent findings that different types of T cells require distinct ganglioside types for the activation. Control of ganglioside expression would offer a strategy targeting for specific T-cell subpopulations to treat immune diseases. This article is part of a Special Issue entitled Linking transcription to physiology in lipodomics.
PMID: 25193136 [PubMed – as supplied by publisher]
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