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Group 2 innate lymphoid cells in lung inflammation.
Immunology. 2013 Jul 19;
Authors: Li BW, Hendriks RW
Abstract
Although allergic asthma is a heterogeneous disease, allergen-specific T helper 2 (Th2) cells producing the key cytokines involved in type 2 inflammation, IL-4, IL-5 and IL-13, are thought to play a major role in asthma pathogenesis. This model is challenged by the recent discovery of group 2 innate lymphoid cells (ILC2) that represent a critical innate source of type 2 cytokines. These ILC2 are activated by epithelial cell-derived cytokines, including IL-25 and IL-33, which have been implicated in the initiation of asthma. In this review, we will discuss recent studies supporting a significant role for ILC2 in lung inflammation, with special attention to allergen-induced asthma. This article is protected by copyright. All rights reserved.
PMID: 23866009 [PubMed – as supplied by publisher]
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