Prenatal Exposure to Bisphenol A and Child Wheeze from Birth to Three Years.
Environ Health Perspect. 2012 Feb 14;
Authors: Spanier AJ, Kahn RS, Kunselman AR, Hornung R, Xu Y, Calafat AM, Lanphear BP
Abstract
Background: Bisphenol A (BPA), an endocrine disrupting chemical that is routinely detected in >90% of Americans, promotes experimental asthma in mice. The association of prenatal BPA exposure and wheeze has not been evaluated in humans. Objective: To examine the relationship between prenatal BPA exposure and wheeze in early childhood. Methods: We measured BPA concentrations in serial maternal urine samples from a prospective birth cohort of 398 mother-infant pairs and assessed parent-reported child wheeze every six months for three years. We used generalized estimating equations (GEE) with a logit link to evaluate the association of prenatal urinary BPA concentration with the dichotomous outcome wheeze (wheeze over the previous six months). Results: Data were available for 365 children; BPA was detected in 99% of maternal urine samples during pregnancy. In multivariable analysis, a 1-unit increase in log-transformed creatinine-standardized mean prenatal urinary BPA concentration was not significantly associated with child wheeze from birth to three years of age, but there was an interaction of BPA concentration with time (p=0.003). Mean prenatal BPA above versus below the median was positively associated with wheeze at age six months [adjusted odds ratio (AOR) 2.3 (95% CI: 1.3, 4.1)], but not at three years (AOR=0.6, 95% CI: 0.3, 1.1). In secondary analyses evaluating associations of each prenatal BPA concentration separately, urinary BPA concentrations measured at 16 weeks gestation were associated with wheeze (AOR 1.2, 95% CI 1.0, 1.5), but not BPA concentrations at 26 weeks of gestation or at birth. Conclusions: Mean prenatal BPA was associated with increased odds of wheeze in early life, and the effect diminished over time. Evaluating exposure at each prenatal time point demonstrated an association between wheeze from six months to three years and log-transformed BPA concentration at 16 weeks gestation only.
PMID: 22334053 [PubMed – as supplied by publisher]
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