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Anti-asthma drugs taken during pregnancy associated with autism risk
Medical Xpress B2AR agonist drugs—which include salmetereol and formoterol—are used to relax the bronchial passages in a person's lungs, providing a release from the constricting nature of asthma. According to the study, B2AR drugs can cross the placenta and reach … Study: Anti-asthma drugs taken during pregnancy associated with autism risk Drexel University |
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Genetic polymorphisms of the TNF-?-308G/A are associated with metabolic syndrome in asthmatic patients from Hebei province, China.
Int J Clin Exp Pathol. 2015;8(10):13739-46
Authors: Yang YH, Liu YQ, Zhang L, Li H, Li XB, Ouyang Q, Zhu GY
Abstract
Asthma is a complex inflammatory disease involving the critical actions of several important cytokines. Epidemiological data show that obesity could increase the risk of asthma, and insulin resistance, or metabolic syndrome are an important risk factor for obesity asthma. Some studies identified that upstream of the transcription start site within the TNF-? gene promoter region-308 polymorphism was associated insulin resistance or metabolic disorders, while this site was closely related to asthma. But no research was performed to evaluate the influence of TNF-?-308G/A polymorphism on metabolic syndrome in asthmatic patients. Here, we recruited 248 asthmatic patients, who were separated into asthma with Mets/asthma without Mets groups and 226 matched healthy controls from Hebei Province to evaluate the influence of TNF-?-308G/A polymorphism on metabolic syndrome in asthmatic patients. Single nucleotide polymorphism of TNF-?-308 locus was genotyped using PCR-RFLP. Some biochemical variables were also determined. Our result showed that the genotypic and allelic frequency of rs1800629 did not show significant difference between asthmatic patients and normal controls. However, the frequency of A allele was signi?cantly higher in asthma group with Mets (22.36%) than in controls (15.71%) (P = 0.02; OR = 0.647; 95% CI = 0.447-0.936). After analyzing the relationship between biochemical features of patients and genotype of TNF-?-308G/A, we found levels of LDL cholesterol, TNF-? and insulin, and HOMA-IR were significantly higher in the asthmatic patients carrying the GA and AA genotypes than in the carriers of GG genotype of rs1800629 (P = 0.029, P = 0.022, P = 0.043, respectively). Thus, our data suggested that TNF-?-308G/A variation was related to metabolic phenotype in asthma patients. Furthermore, we first identified TNF-?-308 A allele was the risk factor for asthmatic patients with Mets in Hebei population, China.
PMID: 26722602 [PubMed – in process]
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Higher levels of physical activity associated with poorer asthma control in …
Healio Patients with asthma had higher levels of activity compared with patients in a control group, with females who had poor asthma control displaying higher levels of activity compared with males in the study, according to recent research published in … |
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STAT6 may explain mortality associated with some asthma drug
Baylor College of Medicine News (press release) The “black box” warning on some long-acting beta agonists – drugs used to ward off asthma attacks – mandates that such medications be sold as combination agents that contain a steroid to prevent the rare episodes of medication-associated deaths. |
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High physical activity levels associated with poorer asthma control in females
News-Medical.net Among 526 adolescents and young adults who were asked about their exercise habits, those with asthma tended to report more physical activity than those without asthma. Compared with moderate physical activity, high physical activity levels were linked … A picture from your cell phone could lead to treatment for acne |
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Anxiety associated with poor asthma outcomes
News-Medical.net Anxiety sensitivity, in simple terms, is a fear of fear. But when people with anxiety sensitivity also have asthma, their suffering can be far more debilitating and dangerous, because they have difficulty managing their asthma. A new study explores … |
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Persistence of Asthma Following Allergen Avoidance is Associated With proTh2 …
Medscape Methods We recruited 32 patients with occupational asthma to flour or latex ascertained by specific inhalation challenge and who were no longer exposed to the causal allergen. Leukapheresis was performed in each patient to isolate and characterise … |
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Atopic dermatitis is associated with Caesarean sections in Korean adolescents but asthma is not.
Acta Paediatr. 2015 Sep 12;
Authors: Yu M, Han K, Kim DH, Nam GE
Abstract
AIM: Studies on the associations between mode of delivery and allergic diseases have produced different results and research has rarely been conducted in Asian countries such as South Korea. This study assessed the relationship between mode of delivery and atopic dermatitis and asthma in Korean adolescents.
METHODS: Data collected from the Korea National Health and Nutrition Examination Survey between 2010 and 2011 were used. We included 1,302 adolescents aged from 12-18 years and multivariable logistic regression analysis was performed.
RESULTS: The odds ratio (OR) of having atopic dermatitis was 1.50, with a 95% confidence interval (95% CI) of 1.01-2.22, after adjusting for age and sex. The association remained significant after further adjustments for body mass index, breastfeeding and serum 25-hydroxyvitamin D level (OR = 1.61, 95% CI = 1.05-2.47) and when fat intake was added to those variables (OR = 1.80, 95% CI = 1.14-2.85). However, asthma was not associated with mode of delivery in any of the models.
CONCLUSIONS: Atopic dermatitis in adolescents was associated with Caesarean delivery, which is common in South Korea. The findings suggest that the frequency of this practice should be reconsidered and that further research with longitudinal evaluation of relevant mechanisms is needed. This article is protected by copyright. All rights reserved.
PMID: 26363368 [PubMed – as supplied by publisher]
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Study: Wildfire smoke exposure associated with increased visits to ER for asthma
News-Medical.net Researchers who analyzed data from the 2006-2007 wildfires in Australia found that exposure to wildfire smoke was linked to increased visits to hospital emergency departments for asthma. The findings reveal the adverse health impacts due to wildfire … |
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Demographic Characteristics of Asthma Subjects Associated With Stepping Down …
AJMC.com Managed Markets Network Methods: Subjects were included if they: 1) had ?2 FSC prescription claims prior to the index (step-down) date, 2) had ?1 asthma claim, 3) were aged 12 to 64 years, and 4) were continuously eligible for 12 months pre- and post index. Subjects were … |
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