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Study holds hope for reversing childhood asthma associated with maternal …
Medical Xpress The study, published online by the American Journal of Physiology – Lung Cellular and Molecular Physiology, reported that a medication that stimulates certain proteins in the body reversed airway damage in disease models of asthma caused by prenatal … |
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Enhanced GWAS Method IDs New Loci Associated With Response to Asthma …
GenomeWeb NEW YORK (GenomeWeb) – By integrating pharmacodynamic modeling into a GWAS analysis, researchers have identified and validated in independent cohorts five loci significantly associated with asthma patients' responses to inhaled glucocorticoid … |
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Asthma Associated With Increased Risk of Obstructive Sleep Apnea
Newswise (press release) Newswise — Participants in a sleep study who had asthma had an increased risk for developing obstructive sleep apnea, with this association stronger with having had asthma longer, according to a study in the January 13 issue of JAMA. In adults … |
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Medical Xpress |
Asthma associated with increased risk of obstructive sleep apnea
Medical Xpress Twenty-two of 81 participants (27 percent) with asthma experienced incident OSA over their first observed 4-year follow-up intervals vs 75 of 466 participants (16 percent) without asthma. Using all available 4-year intervals (i.e., including multiple 4 … |
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Breastfeeding is Associated with Reduced Childhood Hospitalization: Evidence from a Scottish Birth Cohort (1997-2009).
J Pediatr. 2014 Dec 30;
Authors: Ajetunmobi OM, Whyte B, Chalmers J, Tappin DM, Wolfson L, Fleming M, MacDonald A, Wood R, Stockton DL, Glasgow Centre for Population Health Breastfeeding Project Steering Group
Abstract
OBJECTIVE: To evaluate the risk of childhood hospitalization associated with infant feeding patterns at 6-8 weeks of age in Scotland.
STUDY DESIGN: A retrospective population level study based on the linkage of birth, death, maternity, infant health, child health surveillance, and admission records for children born as single births in Scotland between 1997 and 2009 (n = 502?948) followed up to March 2012. Descriptive analyses, Kaplan Meier tests, and Cox regression were used to quantify the association between the mode of infant feeding and risk of childhood hospitalization for respiratory, gastrointestinal, and urinary tract infections, and other common childhood ailments during the study period.
RESULTS: Within the first 6 months of life, there was a greater hazard ratio (HR) of hospitalization for common childhood illnesses among formula-fed infants (HR 1.40; 95% CI 1.35-1.45) and mixed-fed infants (HR 1.18; 95% CI 1.11-1.25) compared with infants exclusively breastfed after adjustment for parental, maternal, and infant health characteristics. Within the first year of life and beyond, a greater relative risk of hospitalization was observed among formula-fed infants for a range of individual illnesses reported in childhood including gastrointestinal, respiratory, and urinary tract infections, otitis media, fever, asthma, diabetes, and dental caries.
CONCLUSIONS: Using linked administrative data, we found greater risks of hospitalization in early childhood for a range of common childhood illnesses among Scottish infants who were not exclusively breastfed at 6-8 weeks of age.
PMID: 25556021 [PubMed – as supplied by publisher]
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Comparison of temporal transcriptomic profiles from immature lungs of two rat strains reveals a viral response signature associated with chronic lung dysfunction.
PLoS One. 2014;9(12):e112997
Authors: Hines EA, Szakaly RJ, Leng N, Webster AT, Verheyden JM, Lashua AJ, Kendziorski C, Rosenthal LA, Gern JE, Sorkness RL, Sun X, Lemanske RF
Abstract
Early life respiratory viral infections and atopic characteristics are significant risk factors for the development of childhood asthma. It is hypothesized that repeated respiratory viral infections might induce structural remodeling by interfering with the normal process of lung maturation; however, the specific molecular processes that underlie these pathological changes are not understood. To investigate the molecular basis for these changes, we used an established Sendai virus infection model in weanling rats to compare the post-infection transcriptomes of an atopic asthma susceptible strain, Brown Norway, and a non-atopic asthma resistant strain, Fischer 344. Specific to this weanling infection model and not described in adult infection models, Sendai virus in the susceptible, but not the resistant strain, results in morphological abnormalities in distal airways that persist into adulthood. Gene expression data from infected and control lungs across five time points indicated that specific features of the immune response following viral infection were heightened and prolonged in lungs from Brown Norway rats compared with Fischer 344 rats. These features included an increase in macrophage cell number and related gene expression, which then transitioned to an increase in mast cell number and related gene expression. In contrast, infected Fischer F344 lungs exhibited more efficient restoration of the airway epithelial morphology, with transient appearance of basal cell pods near distal airways. Together, these findings indicate that the pronounced macrophage and mast cell responses and abnormal re-epithelialization precede the structural defects that developed and persisted in Brown Norway, but not Fischer 344 lungs.
PMID: 25437859 [PubMed – in process]
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2 Minute Medicine |
Childhood exposure to paracetamol not directly associated with increased …
2 Minute Medicine 1. This meta-analysis could not conclusively attribute increased asthma risk to in utero or early life paracetamol exposure. 2. While initial analysis showed an association between paracetamol exposure and asthma risk, controlling for coincident upper … |
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Condition: Asthma
Interventions: Drug: Ipratropium bromide; Drug: Placebo; Drug: Salbutamol
Sponsor: Boehringer Ingelheim
Terminated – verified September 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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Obesity, gestational weight gain associated with child asthma risk
Clinical Advisor The odds were higher in asthma or wheeze ever associated with GWG (OR, 1.16). There was no association between maternal underweight and low GWG and childhood asthma or wheeze. Maternal asthma history showed a negative association of … |
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Redox mechanisms in allergic asthma associated with disease pathogenesis
Healio Redox mechanisms of oxidative stress in allergic asthma played a “critical role” in disease pathogenesis and could be a therapeutic target, according to recent study results. Researchers conducted a literature review of PubMed for redox therapy … |
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