Condition: Asthma
Intervention: Dietary Supplement: Alfacalcidol
Sponsor: Cairo University
Completed – verified April 2016
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Asthmatic children wear monitors to track levels of pollution on way to school – Evening Standard
Evening Standard |
Asthmatic children wear monitors to track levels of pollution on way to school
Evening Standard Asthmatic children are wearing pollution monitors and GPS trackers to measure how much noxious air they breathe in walking to school for a major study by a team of London scientists. Queen Mary University of London researchers are examining whether … |
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Police, coroner won’t comment on how an asthmatic Grade 5 student came to die at Wallaceburg school – National Post
National Post |
Police, coroner won't comment on how an asthmatic Grade 5 student came to die at Wallaceburg school
National Post WALLACEBURG – Ontario's Chief Coroner is probing the sudden death of an asthmatic Grade 5 boy following a medical episode at school. Ten-year-old Javier Guadalupe Avina, whom an online obituary published Thursday remembered as an athletic boy … |
View full post on asthma – Google News
A Phase IIA FF/VI Study to Measure FeNO in Asthmatic Patients.
Condition: Asthma
Interventions: Drug: Fluticasone furoate (FF) (100 mcg); Drug: Vilanterol (VI) (25 mcg); Drug: Placebo
Sponsor: GlaxoSmithKline
Not yet recruiting – verified March 2016
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Gary tudents honored for saving asthmatic teacher’s life after classmate’s cologne causes attack – WLS-TV
WLS-TV |
Gary tudents honored for saving asthmatic teacher's life after classmate's cologne causes attack
WLS-TV Hutchinson taught her students how to handle an asthma attack. The 50-year-old teacher has suffered from severe asthma her whole life. She is allergic to many scents, including cologne. A few weeks ago, Sydn'e Duncan noticed one of her classmates was … |
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HB-EGF-Promoted Airway Smooth Muscle Cells and Their Progenitor Migration Contribute to Airway Smooth Muscle Remodeling in Asthmatic Mouse.
| Related Articles |
HB-EGF-Promoted Airway Smooth Muscle Cells and Their Progenitor Migration Contribute to Airway Smooth Muscle Remodeling in Asthmatic Mouse.
J Immunol. 2016 Jan 29;
Authors: Wang Q, Li H, Yao Y, Lu G, Wang Y, Xia D, Zhou J
Abstract
The airway smooth muscle (ASM) cells’ proliferation, migration, and their progenitor’s migration are currently regarded as causative factors for ASM remodeling in asthma. Heparin-binding epidermal growth factor (HB-EGF), a potent mitogen and chemotactic factor, could promote ASM cell proliferation through MAPK pathways. In this study, we obtained primary ASM cells and their progenitors from C57BL/6 mice and went on to explore the role of HB-EGF in these cells migration and the underlying mechanisms. We found that recombinant HB-EGF (rHB-EGF) intratracheal instillation accelerated ASM layer thickening in an OVA-induced asthmatic mouse. Modified Boyden chamber assay revealed that rHB-EGF facilitate ASM cell migration in a dose-dependent manner and ASM cells from asthmatic mice had a greater migration ability than that from normal counterparts. rHB-EGF could stimulate the phosphorylation of ERK1/2 and p38 in ASM cells but further migration assay showed that only epidermal growth factor receptor inhibitor (AG1478) or p38 inhibitor (SB203580), but not ERK1/2 inhibitor (PD98059), could inhibit rHB-EGF-mediated ASM cells migration. Actin cytoskeleton experiments exhibited that rHB-EGF could cause actin stress fibers disassembly and focal adhesions formation of ASM cells through the activation of p38. Finally, airway instillation of rHB-EGF promoted the recruitment of bone marrow-derived smooth muscle progenitor cells, which were transferred via caudal vein, migrating into the airway from the circulation. These observations demonstrated that ASM remodeling in asthma might have resulted from HB-EGF-mediated ASM cells and their progenitor cells migration, via p38 MAPK-dependent actin cytoskeleton remodeling.
PMID: 26826248 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
Zero Tolerance: Another Texas Student Suspended for Helping Asthmatic Classmate – Breitbart News
Breitbart News |
Zero Tolerance: Another Texas Student Suspended for Helping Asthmatic Classmate
Breitbart News Instead of praise, a Central Texas school district suspended a 15-year-old boy when he rushed a classmate, who was in the throes of an asthma attack, to the school nurse's office in yet another incident of zero tolerance policies overriding common sense. |
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Genetic polymorphisms of the TNF-?-308G/A are associated with metabolic syndrome in asthmatic patients from Hebei province, China.
| Related Articles |
Genetic polymorphisms of the TNF-?-308G/A are associated with metabolic syndrome in asthmatic patients from Hebei province, China.
Int J Clin Exp Pathol. 2015;8(10):13739-46
Authors: Yang YH, Liu YQ, Zhang L, Li H, Li XB, Ouyang Q, Zhu GY
Abstract
Asthma is a complex inflammatory disease involving the critical actions of several important cytokines. Epidemiological data show that obesity could increase the risk of asthma, and insulin resistance, or metabolic syndrome are an important risk factor for obesity asthma. Some studies identified that upstream of the transcription start site within the TNF-? gene promoter region-308 polymorphism was associated insulin resistance or metabolic disorders, while this site was closely related to asthma. But no research was performed to evaluate the influence of TNF-?-308G/A polymorphism on metabolic syndrome in asthmatic patients. Here, we recruited 248 asthmatic patients, who were separated into asthma with Mets/asthma without Mets groups and 226 matched healthy controls from Hebei Province to evaluate the influence of TNF-?-308G/A polymorphism on metabolic syndrome in asthmatic patients. Single nucleotide polymorphism of TNF-?-308 locus was genotyped using PCR-RFLP. Some biochemical variables were also determined. Our result showed that the genotypic and allelic frequency of rs1800629 did not show significant difference between asthmatic patients and normal controls. However, the frequency of A allele was signi?cantly higher in asthma group with Mets (22.36%) than in controls (15.71%) (P = 0.02; OR = 0.647; 95% CI = 0.447-0.936). After analyzing the relationship between biochemical features of patients and genotype of TNF-?-308G/A, we found levels of LDL cholesterol, TNF-? and insulin, and HOMA-IR were significantly higher in the asthmatic patients carrying the GA and AA genotypes than in the carriers of GG genotype of rs1800629 (P = 0.029, P = 0.022, P = 0.043, respectively). Thus, our data suggested that TNF-?-308G/A variation was related to metabolic phenotype in asthma patients. Furthermore, we first identified TNF-?-308 A allele was the risk factor for asthmatic patients with Mets in Hebei population, China.
PMID: 26722602 [PubMed – in process]
View full post on pubmed: asthma
Separated Detroit family with asthmatic son may reunite – The Detroit News
The Detroit News |
Separated Detroit family with asthmatic son may reunite
The Detroit News Siretha Lattimore, Dwayne Cole and their four young children were featured in a joint report by The Detroit News and PBS NewsHour on Wednesday about how emotional trauma and stress contribute to the nation-leading child asthma rates in Detroit. |
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Aerosol Deposition in Asthmatic Obese Women Using Heliox
Conditions: Obese; Asthma
Intervention: Other: nebulizing with heliox and oxygen
Sponsor: Jacqueline de Melo Barcelar
Recruiting – verified December 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days