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Dallas Morning News (blog) |
EPA recognizes Dallas for efforts to improve life for asthmatic kids
Dallas Morning News (blog) Dallas is also among the most ozone-polluted counties in the country and pollution contributes to asthma, according to the release. “Protecting children's health takes the hard work and collaboration of many groups, from healthcare workers to city … |
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New law aimed at protecting asthmatic children in schools
WFMJ Across the country, nearly seven million kids live with asthma according to the Centers for Disease Control and Prevention. It's one of the leading causes of school absenteeism. In Ohio, it is believed that as few at 25% of kids, who have a known … |
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HealthWorks! to host program for families with asthmatic childre – Fox 28 …
Fox 28 If you have a child with asthma and want to learn more about the disease, then you'll want to sign the family up for the Asthma Super Saturday happening this weekend. Memorial Children's Hospital, HealthWorks! and Memorial Hospital's Pulmonary Services … |
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Youth Health Magzine |
Living with a Smoker Makes Asthmatic Kids Worse
Youth Health Magzine The team performed what is called a meta-analysis of data from 25 studies of asthmatic children. Those studies included a total of more than 430,000 children. The review found that children with asthma who were also exposed to second-hand smoke were … |
View full post on asthma – Google News
| Related Articles |
Anti-inflammatory activity of IL-37 in asthmatic children: Correlation with inflammatory cytokines TNF-?, IL-?, IL-6 and IL-17A.
Immunobiology. 2015 Sep 8;
Authors: Charrad R, Berraïes A, Hamdi B, Ammar J, Hamzaoui K, Hamzaoui A
Abstract
BACKGROUND: The aim of this study was to assess interleukin (IL)-37 production in asthmatic children in serum and induced sputum and to look to the impact of IL-37 on pro-inflammatory cytokines production (TNF-?, IL-6, IL-1? and IL-17).
METHODS: Forty children with well-controlled asthma (20 moderate and 20 mild asthmatics) were studied. IL-37 was measured by ELISA in serum and induced sputum (IS) samples, and compared with 22 age- and sex-matched healthy controls. Real-time quantitative PCR was used to determine IL-37 mRNA expression in induced sputum cells. Induced sputum mononuclear cells from 10 moderate asthmatics and 10 healthy controls were stimulated either with lipopolysaccharides (LPS) or LPS plus recombinant IL-37 (rIL-37) comparing pro-inflammatory cytokines production. TNF-?, IL-1?, IL-6 and IL-17 were measured by RT-PCR and ELISA.
FINDINGS: The expression of IL-37 mRNA in asthmatic patients was significantly lower than that observed in healthy controls (P=0.0001). IL37 mRNA expression depended on asthma severity. Serum and IS IL-37 levels were significantly lower in asthma patients compared to healthy controls. LPS-stimulated sputum cells from asthma patients produced higher levels of IL-1?, IL-6, and TNF-? than those from HC. Adding rIL-37 suppressed TNF-?, IL-1? and IL-6 production in IS cells. In the same way, stimulating IS CD4(+) T cells in the presence of rIL-37 inhibited IL-17 production both in asthma patients and HC. IL-37 effect on IL-17 was more pronounced in patients than controls.
INTERPRETATION: The decrease in IL-37 level observed in IS was found to correlate with disease severity. The increased pro-inflammatory cytokines production from asthma IS cells was abrogated by the addition of rIL-37. IL-37 could be an important cytokine in the control of asthma by suppressing the production of inflammatory cytokines.
PMID: 26454413 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
Conditions: Asthma (Part 1); COPD (Part 2)
Interventions: Drug: Dose 1, AZD8871 50 ?g (Part 1); Drug: Dose 2, AZD8871 100 ?g (Part 1); Drug: Dose 3, AZD8871 300 ?g (Part 1); Drug: Dose 4, AZD8871 600 µg (Part 1); Drug: Dose 5, AZD8871 1200 µg (Part 1); Drug: Dose 6, AZD8871 1800 ?g (Part 1); Drug: Placebo, AZD8871 placebo (Part 1); Drug: Treatment A, AZD8871 dose A (Part 2); Drug: Treatment B, AZD8871 dose B (Part 2); Drug: Treatment C, Indacaterol 150 ?g (Part 2); Drug: Treatment D, Tiotropium 18 ?g (Part 2)
Sponsor: AstraZeneca
Not yet recruiting – verified October 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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Doctor Channels MacGyver to Help Asthmatic Toddler Aboard Transatlantic Flight
ABC News A New York doctor became a hero in the skies recently when he turned into a medical MacGyver by creating a device that helped an asthmatic toddler struggling to breathe during a transatlantic flight. Dr. Khurshid Guru, director of Robotic Surgery at … |
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Telegraph.co.uk |
Asthmatic sea otter taught to use inhaler
Telegraph.co.uk This is Mishka, a one-year-old sea otter who has been taught how to use an asthma inhaler by keepers at Seattle Aquarium, Washington State. In the video, the wheezy otter is seen using an asthma spacer to inhale the drug which will help her breathe easier. 'Mishka' the sea otter learns how to use an inhaler after she develops asthma |
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The Guardian |
Asthmatic sea otter learns to use inhaler – video
The Guardian One-year-old Mishka has asthma and is the first sea otter to be diagnosed with the disease. Cats and horses are two other animals that more commonly get asthma. A King 5 TV news report explains that Mishka began having trouble breathing when smoke … |
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KIRO Seattle |
Asthmatic Seattle Aquarium otter using inhaler after wildfire smoke
KIRO Seattle Mishka most likely had low-grade asthma before the wildfires. The aquarium wrote in a blog post that it's difficult to say exactly why the otter has asthma, but sometimes it's a mixture of genetics, environmental exposure, sometimes it's just exposure … Asthmatic sea otter learns to use inhaler Seattle Aquarium trains otter to use inhaler for her asthma Seattle Aquarium Trains Otter to Use Inhaler for Asthma |
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