Condition: Asthma
Intervention: Drug: ABS eMDPI
Sponsor: Teva Branded Pharmaceutical Products, R&D Inc.
Not yet recruiting – verified November 2016
View full post on ClinicalTrials.gov: asthma | Studies received in the last 14 days
Relationship between Pesticide Metabolites, Cytokine Patterns, and Asthma-Related Outcomes in Rural Women Workers.
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Relationship between Pesticide Metabolites, Cytokine Patterns, and Asthma-Related Outcomes in Rural Women Workers.
Int J Environ Res Public Health. 2016;13(10)
Authors: Mwanga HH, Dalvie MA, Singh TS, Channa K, Jeebhay MF
Abstract
The objective of this study was to investigate the relationship between exposure to organophosphate (OP) and pyrethroid (PYR) pesticides with serum cytokine patterns and asthma-related outcomes among rural women workers. A cross-sectional study was conducted among rural women (n = 211), including those working and living on farms and nearby town dwellers. Pesticide exposure was assessed using urinary metabolite concentrations of OP and PYR pesticides. Health outcome assessment was ascertained through the European Community Respiratory Health Survey (ECRHS) questionnaire, fractional exhaled nitric oxide (FeNO), and serum cytokines associated with asthma. The prevalence of doctor-diagnosed asthma was 11%, adult-onset asthma 9%, and current asthma 6%. In this population, the proportion of T helper type 2 (Th2) cytokines (interleukin (IL)-4, IL-5, and IL-13) detectable in subjects was between 18% and 40%, while the proportion of non-Th2 cytokines (IL-6, IL-8, IL-10, IL-17, and interferon gamma) was between 35% and 71%. Most Th2 and non-Th2 cytokines were positively associated with either OP or PYR metabolites. Non-Th2 cytokines showed much stronger associations with OP metabolites (Dimethyl phosphate OR = 4.23; 95% CI: 1.54-11.65) than Th2 cytokines (Dimethyl phosphate OR = 1.69; 95% CI: 0.83-3.46). This study suggests that exposure to most OP and some PYR pesticides may be associated with asthma-related cytokines, with non-Th2 cytokines demonstrating consistently stronger relationships.
PMID: 27690066 [PubMed – as supplied by publisher]
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Controlling childhood asthma: Study shows ‘mismatch’ between doctors’ instructions, parents’ understanding – Safety+Health magazine
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Controlling childhood asthma: Study shows 'mismatch' between doctors' instructions, parents' understanding
Safety+Health magazine Boston – A Harvard Medical School study of parents whose children have asthma shows roughly half do not know which type of asthma-control medication their child is taking and how often it should be used. The researchers surveyed the parents and health … Kids' Asthma Severity Under-Recognized & Undertreated at Routine Healthcare Visits |
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IMPACT OF TRIALS ON CLINICAL PRACTICE: INTERVENTIONS IN SEPTIC SHOCK PATIENTS BETWEEN 2005 AND 2013.
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IMPACT OF TRIALS ON CLINICAL PRACTICE: INTERVENTIONS IN SEPTIC SHOCK PATIENTS BETWEEN 2005 AND 2013.
Intensive Care Med Exp. 2015 Dec;3(Suppl 1):A430
Authors: Jones A, Bond A, Whiteley C, Cendreda B, Shankar-Hari M
PMID: 27289981 [PubMed]
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Health department study suggests link exists between asthma, depression – fox13now.com
fox13now.com |
Health department study suggests link exists between asthma, depression
fox13now.com SALT LAKE CITY — Thousands of people across Utah have spent the past month raising awareness for two serious conditions: asthma and mental health. Now, a new study from the Utah Department of Health links those conditions, with findings indicating … |
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South Africa: The Link Between Asthma, Stress and Depression Among South African Kids – AllAfrica.com
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South Africa: The Link Between Asthma, Stress and Depression Among South African Kids
AllAfrica.com Asthma is the most common chronic disease among children worldwide. Yet for many years children in high-income countries were thought to be those mainly affected. However, asthma studies from the past 25 years not only call this view into question … |
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Researchers Funded to Study Links Between Depression and Asthma – UB School of Medicine and Biomedical Sciences News
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Researchers Funded to Study Links Between Depression and Asthma
UB School of Medicine and Biomedical Sciences News Studies have shown that children with asthma are at higher risk for depression, and research also has shown an association between a parent or caregiver's depression and worsening symptoms in an asthmatic child. Bruce D. Miller, MD, and Beatrice L. |
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Link Found Between Asthma and a Higher Risk of Abdominal Aortic Aneurysms – Lung Disease News
Lung Disease News |
Link Found Between Asthma and a Higher Risk of Abdominal Aortic Aneurysms
Lung Disease News In a new study, researchers found that recent active asthma in patients aged 50 years or older increased the risk for abdominal aortic aneurysms (AAA) and their rupture. The research article, “Asthma Associates with Human Abdominal Aortic Aneurysm and … |
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Sex differences in the association between neck circumference and asthma.
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Sex differences in the association between neck circumference and asthma.
Pediatr Pulmonol. 2016 Jan 15;
Authors: Maltz L, Matz EL, Gordish-Dressman H, Pillai DK, Teach SJ, Camargo CA, Hubal MJ, Behniwal S, Prosper GD, Certner N, Marwah R, Mansell DM, Nwachukwu F, Lazaroff R, Tsegaye Y, Freishtat RJ
Abstract
INTRODUCTION: The association between obesity and asthma control/quality of life commonly relies on body mass index (BMI) as the anthropomorphic measure. Due to limitations of BMI and the existence of alternative measures, such as neck circumference (NC), we examined the association between NC and asthma control/quality of life, with particular attention to male-female differences.
MATERIALS AND METHODS: The AsthMaP-2 Project is an observational study of youth with physician-diagnosed asthma. NC was stratified according to age- and sex-specific cutoffs and associated with asthma control (via Asthma Control Test [ACT]) and quality of life (via Integrated Therapeutics Group [ITG]-Asthma Short Form).
RESULTS: The mean?±?SD age was 11.9?±?3.6 years, and 53% were male (N?=?116). The mean BMI percentile was at the 71?±?28 percentile. Thirty-one participants (27%) met criteria for high NC. Males with high NC had significantly worse asthma control (P?=?0.02) and lower quality of life than those with low NC. No similar association was found for females and the proportion of variability in ACT and ITG was best explained by BMI percentile. Conversely, for males, the proportion of variability in these scores explained by NC was larger than BMI percentile alone (Cohen’s f(2) ?=?0.04-0.09, a small to medium effect size).
DISCUSSION: Among male youth with asthma, combined use of NC and BMI percentile explained asthma control and quality of life better than BMI alone. Future studies of asthma should include measurement of NC and other anthropogenic measures of regional adiposity to clarify sex differences in asthma. Pediatr Pulmonol. © 2016 Wiley Periodicals, Inc.
PMID: 26774073 [PubMed – as supplied by publisher]
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Scientists discover link between Shingles and Asthma – Bel Marra Health
Bel Marra Health |
Scientists discover link between Shingles and Asthma
Bel Marra Health According to Dr. Young Juhn, an asthma epidemiologist at the Mayo Clinic Children's Research Center in Rochester, and the author of the new study, “Asthma represents one of the five most burdensome chronic diseases in the U.S., affecting up to 17 … History of Asthma May Be Linked to Shingles Risk in Adults |
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