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Relationships between impulse oscillometry, spirometry and dyspnoea in COPD.

Relationships between impulse oscillometry, spirometry and dyspnoea in COPD.

J R Coll Physicians Edinb. 2012 Jun;42(2):111-5

Authors: Anderson WJ, Lipworth BJ

Abstract
Background: Severity of chronic obstructive pulmonary disease (COPD) is based either on symptoms/disability or lung function, which have no discernible correlation. We hypothesised that impulse oscillometry (IOS), a non-effortdependent measure of central and peripheral airway mechanics, could correlate to dyspnoea in COPD. Methods: We analysed screening data from 57 COPD patients who had spirometry, IOS and Medical Research Council dyspnoea score (MRC) measurements. We searched for predictors or correlations of MRC from IOS, spirometry and demographics. Results: MRC had no significant predictors or correlations from IOS, spirometry or demographics (possibly excepting smoking history, p=0.05). IOS correlated significantly with spirometry: FEV1 and FEF25-75 vs. R5-R20 (peripheral airway resistance), r= -0.499, p > 0.001 and r= -0.397, p= 0.002 respectively. Conclusion: MRC is not related to IOS or spirometry in COPD. IOS correlates well with spirometry, particularly peripheral airway resistance (R5-R20). IOS is useful, but does not provide a link between symptoms and pulmonary function measurements.

PMID: 22693693 [PubMed – in process]

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Updates in the relationship between human rhinovirus and asthma.

Updates in the relationship between human rhinovirus and asthma.

Allergy Asthma Immunol Res. 2012 May;4(3):116-21

Authors: Kim WK, Gern JE

Abstract
Human rhinovirus (HRV) is a nonenveloped, single stranded RNA virus belonging to the family Picornaviridae. HRV infections can cause both upper and lower respiratory illnesses in children and adults. Lower respiratory illnesses are more likely to occur in specific high risk groups, including infants, and children and adults with asthma. The relationships between rates of infection and the risk of clinical illness and exacerbation are not completely understood. Recent studies employing polymerase chain reaction and other molecular techniques indicate that there are new branches on the HRV family tree, and one characteristic of recently detected viruses is that they cannot be detected by standard tissue culture. Here we review the current literature and discuss new advances in understanding the link between HRV and asthma.

PMID: 22548203 [PubMed – in process]

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Strong link between BMI and asthma in Hispanic youth – News-Medical.net

Strong link between BMI and asthma in Hispanic youth
News-Medical.net
Children and adolescents who are overweight or obese are more likely to have asthma than their healthy weight counterparts, according to a new Kaiser Permanente Southern California study published in the online edition of Obesity.
Kaiser Permanente Study Finds Obesity-Asthma Link in Children Varies by Race …MarketWatch (press release)

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Relationship between air pollution, NFE2L2 gene polymorphisms and childhood asthma in a Hungarian population.

Relationship between air pollution, NFE2L2 gene polymorphisms and childhood asthma in a Hungarian population.

J Community Genet. 2011 Dec 30;

Authors: Ungvári I, Hadadi E, Virág V, Nagy A, Kiss A, Kalmár A, Zsigmond G, Semsei AF, Falus A, Szalai C

Abstract
Air pollution and subsequent increased oxidative stress have long been recognized as contributing factors for asthma phenotypes. Individual susceptibility to oxidative stress is determined by genetic variations of the antioxidant defence system. In this study, we analysed the association between environmental nitrogen dioxide (NO(2)) exposure and single nucleotide polymorphisms (SNP) in NFE2L2 and KEAP1 genes and their common impact on asthma risk. We genotyped 12 SNPs in a case-control study of 307 patients diagnosed with asthma and 344 controls. NO(2) concentration was collected from the period preceding the development of asthma symptoms. Multiple logistic regression was applied to evaluate the effects of the studied genetic variations on asthma outcomes in interaction with NO(2) exposure. Our data showed that genotypes of rs2588882 and rs6721961 in the regulatory regions of the NFE2L2 gene were inversely associated with infection-induced asthma (odds ratio (OR)?=?0.290, p?=?0.0015, and OR?=?0.437, p?=?0.007, respectively). Furthermore, case-only analyses revealed significant differences for these SNPs between asthma patients that lived in modestly or highly polluted environment (OR?=?0.43 (0.23-0.82), p?=?0.01, and OR?=?0.51, p?=?0.02, respectively, in a dominant model). In conclusion, our results throw some new light upon the impact of NFE2L2 polymorphisms on infection-induced asthma risk and their effect in gene-environment interactions.

PMID: 22207565 [PubMed – as supplied by publisher]

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Is There A Link Between Acetaminophen and Asthma? – Care2.com (blog)

Is There A Link Between Acetaminophen and Asthma?
Care2.com (blog)
by Annie Urban A new study published in Pediatrics, the journal of the American Academy of Pediatrics, has documented an epidemiologic association between the use of acetaminophen (eg Tylenol) and the prevalence of asthma in children and adults. …
What to do if your child has asthmaBismarck Tribune

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