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Lung disease IL-25 blockade could reduce virus-associated asthma attacks
Nature.com Approximately 85% of asthma exacerbations, also known as asthma attacks, are triggered by respiratory viruses and are characterized by an elevated type 2 immune response. Beale et al. now show that infection with rhinoviruses, the most common type of … |
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Treatment of Aspirin Exacerbated Respiratory Disease with a Low Salicylate Diet: A Pilot Crossover Study.
Otolaryngol Head Neck Surg. 2014 Oct 24;
Authors: Sommer DD, Hoffbauer S, Au M, Sowerby LJ, Gupta MK, Nayan S
Abstract
OBJECTIVE: Aspirin exacerbated respiratory disease (AERD) is comprised of aspirin/acetylsalicylic acid (ASA) sensitivity, bronchial asthma, and nasal polyposis. Treatment of this condition is challenging and may include topical/systemic steroids, endoscopic sinus surgery, and/or aspirin desensitization.
STUDY DESIGN: A prospective crossover pilot study (n = 10) was conducted in which patients were randomized into either of 2 groups with 6 weeks of regular diet (R) or 6 weeks of a low salicylate diet (LS).
SETTING: The study was conducted in a tertiary otolaryngology clinic.
SUBJECTS: Patients with AERD were enrolled in the study.
METHODS: Subjective (Sino-nasal Outcome Test-22 [SNOT-22], Nasal Sinus Symptom Scale [NSSS], and the Asthma Control Questionnaire-7 [ACQ-7]) and objective outcome instruments (Peri-Operative Sinus Evaluation [POSE] and Lund-Kennedy Endoscopic Score [LKES]) were used to evaluate patients at baseline, 6 weeks (at crossover), and 12 weeks.
RESULTS: Wilcoxon rank sum tests demonstrated that patients on the low salicylate diet had improved scores compared to their regular diet when evaluated by 4 of the 5 outcome measures (SNOT-22 pLS = 0.0059, NSSS pLS = 0.0195, LKES pLS = 0.0039, POSE pLS = 0.005).
CONCLUSION: Results of the pilot study indicate that implementation of a low salicylate diet improves the nasal symptoms and nasal endoscopy findings of individuals with AERD. Further research is required to support these findings.
PMID: 25344589 [PubMed – as supplied by publisher]
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Lung Disease News |
Pulmonica Harmonica Helps Patients Manage Asthma, COPD According To …
Lung Disease News shutterstock_93530611 Asthma can be a debilitating chronic condition. For some, it is relatively easy to keep attacks at bay, but many suffer from daily asthma flare ups that can greatly reduce one's quality of life. This is especially true among children. |
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Conditions: Pulmonary Disease, Chronic Obstructive; Overweight
Interventions: Dietary Supplement: Resveratrol; Dietary Supplement: Placebo
Sponsors: Maastricht University Medical Center; The Netherlands Asthma Foundation; DSM Nutritional Products, Inc.
Not yet recruiting – verified September 2014
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Lung Disease News |
Better Outcomes For COPD Patients Related to LABAs and ICSs
Lung Disease News “Our finding of an association between LABAs and ICSs and outcomes helps clarify the management of patients with COPD and asthma, as many studies of COPD medications have excluded people with asthma and vice versa,” the authors write. “In addition … |
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Study shows how Portland trees curb asthma, other respiratory disease
Portland Tribune Portland's tree canopy removes enough nitrogen dioxide from the air to save society $6.6 million a year, based on avoided health care costs and the value of missed school and work days, according to a study by Portland State University researchers. |
View full post on asthma – Google News
Condition: Aspirin Exacerbated Respiratory Disease (AERD)
Interventions: Drug: Ifetroban, Oral Capsule; Drug: Placebo, Oral Capsule
Sponsor: Cumberland Pharmaceuticals
Active, not recruiting – verified August 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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Inhaled bronchodilators for acute chest syndrome in people with sickle cell disease.
Cochrane Database Syst Rev. 2014 Aug 2;8:CD003733
Authors: Knight-Madden JM, Hambleton IR
Abstract
BACKGROUND: Bronchodilators are used to treat bronchial hyper-responsiveness in asthma. Bronchial hyper-responsiveness may be a component of acute chest syndrome in people with sickle cell disease. Therefore, bronchodilators may be useful in the treatment of acute chest syndrome.
OBJECTIVES: To assess the benefits and risks associated with the use of bronchodilators in people with acute chest syndrome.
SEARCH METHODS: We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register comprising references identified from comprehensive electronic database searches, handsearches of relevant journals and abstract books of conference proceedings. Additional searches were carried out on MEDLINE (1966 to 2002) and Embase (1981 to 2002).Date of the most recent search of the Group’s Haemoglobinopathies Trials Register: 17 March 2014.
SELECTION CRITERIA: Randomised or quasi-randomised controlled trials. Trials using quasi-randomisation methods will be included in future updates of this review if there is sufficient evidence that the treatment and control groups are similar at baseline.
DATA COLLECTION AND ANALYSIS: We found no trials investigating the use of bronchodilators for acute chest syndrome in people with sickle cell disease.
MAIN RESULTS: We found no trials investigating the use of bronchodilators for acute chest syndrome in people with sickle cell disease.
AUTHORS’ CONCLUSIONS: If bronchial hyper-responsiveness is an important component of some episodes of acute chest syndrome in people with sickle cell disease, the use of inhaled bronchodilators may be indicated. There is need for a well-designed, adequately-powered randomised controlled trial to assess the benefits and risks of the addition of inhaled bronchodilators to established therapies for acute chest syndrome in people with sickle cell disease.
PMID: 25086371 [PubMed – as supplied by publisher]
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New Study: Childhood Asthma and Lung Disease Elevated Near Airports
WCVB Boston Living next to an airport can be bothersome—from the noise of airplanes taking off and landing to the extra traffic caused by cars carrying people to and from their flights. A recent report from the Massachusetts Department of Public Health offers up … |
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Heart disease higher locally than Cincinnati
Georgetown News Democrat For eight out of 10 conditions discussed in the survey, people with a lower level of education had the condition more often than those with more education, as was the case for asthma, diabetes, high blood pressure, chronic lung disease, heart trouble … More locals facing serious illness, poll shows Feeling low? You're not alone. Chronic illness rates on the rise in Cincinnati |
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