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The Effect of Asthma on Fertility
Medscape It's not a surprise to learn that an inflammatory condition may affect fertility, but there may be more to it with asthma. A Danish study looked at both monozygotic and dizygotic twin sisters in which one had asthma and the other did not. The findings … |
View full post on asthma – Google News
Conditions: Childhood Asthma; Allergy
Interventions: Device: Ventilation; Device: Placebo Ventilation
Sponsor: University of Aarhus
Recruiting – verified February 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Conditions: Prednisone Dependent Asthma; Eosinophilic Bronchitis
Interventions: Biological: Omalizumab (Xolair); Drug: Placebo
Sponsors: McMaster University; Parameswaran Nair; Novartis
Not yet recruiting – verified January 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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New statistic model forecasts the effect of tobacco consumption on childhood …
YottaFire A scientific study recently published on International Journal of Statistics in Medical Research states that tobacco consumption must be decreased by 15% in Spain, particularly at home, in order to reduce the number of childhood asthma cases. The … |
View full post on asthma – Google News
The Almagest |
New statistic model forecasts the effect of tobacco consumption on childhood …
The Almagest A scientific study published on International Journal of Statistics in Medical Research states that tobacco consumption must be decreased by 15% in Spain, particularly at home, in order to reduce the number of childhood asthma cases. The research is … |
View full post on asthma – Google News
Science World Report |
Taking probiotics during pregnancy has no effect on asthma rate amoung infants
News-Medical.net Taking probiotics has health benefits but preventing childhood asthma isn't one of them, shows newly published research led by medical scientists at the University of Alberta. Meghan Azad, a Banting post-doctoral fellow in the Faculty of Medicine … Taking probiotics during pregnancy doesn't prevent asthma in kids Probiotics during Pregnancy won't Help Prevent Asthma: Study |
View full post on asthma – Google News
Conditions: Eosinophilic Bronchitis; Cough Variant Asthma
Intervention: Drug: Bambuterol Hydrochloride tablets
Sponsor: The First Affiliated Hospital of Guangzhou Medical University
Recruiting – verified December 2013
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Condition: Asthma
Interventions: Drug: Clopidogrel; Drug: Placebo
Sponsors: University of Southampton; University of Southampton
Recruiting – verified September 2013
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Condition: Peripheral Arterial Diseases
Intervention: Drug: Active comparator (cilostazol) and Placebo comparator
Sponsors: National Cheng-Kung University Hospital; National Cheng-Kung University Hospital; Department of Health, Executive Yuan, R.O.C. (Taiwan)
Active, not recruiting – verified September 2013
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
The effect of omalizumab on ventilation and perfusion in adults with allergic asthma.
Am J Nucl Med Mol Imaging. 2013;3(4):350-60
Authors: Kelmenson DA, Kelly VJ, Winkler T, Kone MT, Musch G, Melo MF, Venegas JG, Harris RS
Abstract
Omalizumab promotes clinical improvement in patients with allergic asthma, but its effect on pulmonary function is unclear. One possibility is that omalizumab improves asthma symptoms through effects on the regional distributions of ventilation, perfusion, and ventilation/perfusion matching, metrics which can be assessed with Nitrogen-13-saline Position Emission Tomography (PET). Four adults with moderate to severe uncontrolled allergic asthma underwent symptom assessment, spirometry and functional pulmonary imaging with Nitrogen-13-saline PET before and after 4-5 months of treatment with omalizumab. PET imaging was used to determine ventilation/perfusion ratios, the heterogeneity (coefficient of variation, COV) of ventilation and perfusion, and lung regions with ventilation defects. There were no significant changes in spirometry values after omalizumab treatment, but there was a trend towards an improvement in symptom scores. There was little change in the matching of ventilation and perfusion. The COV of perfusion was similar before and after omalizumab treatment. The COV of ventilation was also similar before (0.57 (0.28)) and after (0.66 (0.13)) treatment, and it was similar to previously published values for healthy subjects. There was a non-significant trend towards an increase in the extent of ventilation defects after omalizumab treatment, from 5 (15)% to 12.8 (14.7)%. Treatment of moderate to severe uncontrolled allergic asthma with omalizumab did not result in a significant improvement in ventilation and perfusion metrics assessed with functional PET imaging. The normal COV of ventilation which was unaffected by treatment supports the hypothesis that omalizumab exerts its clinical effect on lung function during allergen exposure rather than in between exacerbations.
PMID: 23901360 [PubMed]
View full post on pubmed: asthma