The Effect of Intranasal Vasoconstrictor Medications on Hemodynamic Parameters: A Randomized Double-blind, Placebo-controlled Trial.

Conditions:   Epistaxis;   Blood Pressure
Interventions:   Drug: Oxymetazoline 0.05%;   Drug: Phenylephrine 0.25%;   Drug: Lidocaine 1% plus epinephrine 1:100,000;   Drug: Bacteriostatic 0.9% NaCL
Sponsor:   Mayo Clinic
Recruiting – verified November 2014

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No Adjuvant Effect of Bacillus thuringiensis-Maize on Allergic Responses in Mice.

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No Adjuvant Effect of Bacillus thuringiensis-Maize on Allergic Responses in Mice.

PLoS One. 2014;9(8):e103979

Authors: Reiner D, Lee RY, Dekan G, Epstein MM

Abstract
Genetically modified (GM) foods are evaluated carefully for their ability to induce allergic disease. However, few studies have tested the capacity of a GM food to act as an adjuvant, i.e. influencing allergic responses to other unrelated allergens at acute onset and in individuals with pre-existing allergy. We sought to evaluate the effect of short-term feeding of GM Bacillus thuringiensis (Bt)-maize (MON810) on the initiation and relapse of allergic asthma in mice. BALB/c mice were provided a diet containing 33% GM or non-GM maize for up to 34 days either before ovalbumin (OVA)-induced experimental allergic asthma or disease relapse in mice with pre-existing allergy. We observed that GM-maize feeding did not affect OVA-induced eosinophilic airway and lung inflammation, mucus hypersecretion or OVA-specific antibody production at initiation or relapse of allergic asthma. There was no adjuvant effect upon GM-maize consumption on the onset or severity of allergic responses in a mouse model of allergic asthma.

PMID: 25084284 [PubMed – in process]

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Effect of Different Positions on FVC and FEV1 Measurements of Asthmatic Patients.

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Effect of Different Positions on FVC and FEV1 Measurements of Asthmatic Patients.

J Phys Ther Sci. 2014 Apr;26(4):591-3

Authors: Melam GR, Buragadda S, Alhusaini A, Alghamdi MA, Alghamdi MS, Kaushal P

Abstract
[Purpose] The purpose of our study was to investigate the effect of different positions on pulmonary function test (PFT) values such as forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) of asthmatic patients .[Subjects and Methods] Thirty subjects with severe asthma aged between 20-39 years were enrolled after they had signed a written consent. Subjects were selected using the inclusion criteria, and PFT were randomly administered. Spirometer measurements (FVC, FEV1) were taken in the supine, side lying on right, side lying on left, sitting and standing positions. Each measurement was taken three times, and the average values were analyzed. [Results] One- way analysis of variance (ANOVA) and Tukey’s Test (post hoc) for pair- wise comparison indicated that there was a significant difference in the FEV1 values of the asthmatic patients however a significant difference was obtained between standing and supine positions. There was also a significant difference in the FVC values between the standing and supine lying position in the pair -wise comparison. [Conclusion] This study showed standing is the best position for measuring FEV1 and FVC of asthmatic subjects. The more upright the position, the higher the FEV1 and FVC will be.

PMID: 24764640 [PubMed]

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Asthma Attacks Children Fall as Smoking Bans Come Into Effect – Guardian Liberty Voice


Guardian Liberty Voice

Asthma Attacks Children Fall as Smoking Bans Come Into Effect
Guardian Liberty Voice
asthma A new study shows that asthma attacks in children have fallen as smoking bans have come into effect. The researchers from the University of Edinburgh, Maastricht University in the Netherlands, Hasselt University in Belgium, Harvard Medical
Smoking bans cut premature births and child asthma attacksBangor Daily News
Smoking Bans Linked to Drop in Premature Births, Kids' Asthma AttacksU.S. News & World Report
Smoke-free laws linked to improved child healthThorne Gazette

all 161 news articles »

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