Effects of Multidisciplinary Interventions in Elderly Asthma Patients With Risk of Acute Exacerbation

Conditions:   Asthma;   Aged
Interventions:   Dietary Supplement: Magnesium;   Behavioral: Education for asthma action plan;   Behavioral: hot-lines for acute exacerbation of asthma;   Behavioral: Inhaler technique training
Sponsors:   Seoul National University Hospital;   Sang-Heon Cho;   Korean Center for Disease Control and Prevention
Active, not recruiting – verified April 2013

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Half of asthma patients underestimate exacerbation risk – Pulse


BBC News

Half of asthma patients underestimate exacerbation risk
Pulse
More than half of asthma patients did not consider themselves at risk of an asthma attack, despite many having at least one risk factor for an exacerbation, claims an asthma charity. Asthma UK estimates over two million patients are at risk of an
People in Northern Ireland 'unaware of asthma risks'BBC News
Charity: Attitude of 'it's just asthma' needs to changeITV News
Chief ExecutiveThird Sector

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Baylor Researcher to Study Air Pollution, Asthma Exacerbation in Fort Worth … – Baylor University

Baylor Researcher to Study Air Pollution, Asthma Exacerbation in Fort Worth
Baylor University
A new study by Baylor University environmental researchers will look at asthma rates, regional air contaminants, pollution source and contaminant particle size in a Tarrant county school district near Fort Worth. In 2009, childhood asthma in Tarrant

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Lower Airway Rhinovirus Burden and the Seasonal Risk of Asthma Exacerbation.

Lower Airway Rhinovirus Burden and the Seasonal Risk of Asthma Exacerbation.

Am J Respir Crit Care Med. 2011 Aug 4;

Authors: Denlinger LC, Sorkness RL, Lee WM, Evans M, Wolff M, Mathur S, Crisafi G, Gaworski K, Pappas TE, Vrtis R, Kelly EA, Gern JE, Jarjour NN

RATIONALE: Most asthma exacerbations are initiated by viral upper respiratory illnesses. It is unclear whether HRV-induced exacerbations are associated with greater viral replication and neutrophilic inflammation compared to HRV colds. OBJECTIVES: To evaluate viral strain and load in a prospective asthma cohort during a natural cold. METHODS: Adults were enrolled at the first sign of a cold with daily monitoring of symptoms, medication use, and peak expiratory flow rate until resolution. Serial nasal lavage and induced sputum samples were assessed for viral copy number, and inflammatory cell counts. MEASUREMENTS AND MAIN RESULTS: Fifty-two persons with asthma and 14 non-atopic, non-asthmatic controls were studied for over 10 weeks/subject on average; twenty-five participants developed an asthma exacerbation. Detection of human rhinoviruses (HRV) in the preceding 5 days was the most common attributable exposure related to exacerbation. Compared to other infections, those by a minor group A HRV were 4.4-fold more likely to cause exacerbation (p = 0.038). Overall, sputum neutrophils and the burden of rhinovirus in the lower airway were similar in non-atopic controls and the asthma group. However, among HRV-infected participants with asthma, exacerbations were associated with greater sputum neutrophil counts (p = 0.005). CONCLUSIONS: HRV infection is a frequent cause of exacerbations in adults with asthma and a cold and there may be group-specific differences in severity of these events. The absence of large differences in viral burden among groups suggests differential lower airway sensitization to the effects of neutrophilic inflammation in the patients having exacerbations.

PMID: 21816938 [PubMed – as supplied by publisher]

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Asthma exacerbation and proximity of residence to major roads: a population … – 7thSpace Interactive (press release)

Asthma exacerbation and proximity of residence to major roads: a population
7thSpace Interactive (press release)
The relationship between asthma and traffic-related pollutants has received considerable attention. The use of individual-level exposure measures, such as residence location or proximity to emission sources, may avoid ecological biases.

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No Benefit to Increased Inhaled Steroids in Asthma Exacerbation – Internal Medicine News Digital Network


Internal Medicine News Digital Network

No Benefit to Increased Inhaled Steroids in Asthma Exacerbation
Internal Medicine News Digital Network
Major Finding: There were no significant differences in symptoms or in progression to oral corticosteroids among children given two to eight times their maintenance does of inhaled corticosteroids at the start of an asthma exacerbation.
AAAAI: Long-Acting Beta Agonist Combo Okay for KidsMedPage Today

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