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Lung Disease News |
Reslizumab Reduces Risk of Severe Asthma Exacerbations
Lung Disease News A total of 953 patients took part in the two double-blind, parallel-group, randomized, placebo-controlled phase 3 trials from 232 health centers around the world. Patients had asthma that has been difficult to control with normal steroid therapy. For … |
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Scicasts (press release) (registration) (blog) |
Anti-IL-5 Cuts Exacerbations in Eosinophil Asthma
MedPage Today In one of the studies, the clinical asthma exacerbation (CAE) rate was halved (rate ratio 0.50, 95% CI 0.37-0.67, P<0.0001) among patients receiving reslizumab compared with those given placebo, reported Mario Castro, MD, MPH, of Washington University … Investigational drug can reduce asthma flareups Investigational biologics among emerging therapies for severe asthma Investigational Drug Could Reduce Asthma Flareups |
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Eosinophilic Asthma: Reducing Exacerbations and Steroid Use
Medscape This study focused on the use of a novel humanized monoclonal antibody against interleukin-5 (IL-5) in patients with severe eosinophilic-related asthma. We all take care of patients who, despite optimal inhaled therapy and the use of other oral agents … |
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2 Minute Medicine |
Misoprostol not linked to peripartum asthma exacerbations
2 Minute Medicine PGE1 is typically considered a bronchodilator, but prior work has suggested that certain conditions, including pregnancy and hyperdynamic bronchial sensitivity an in asthma, can predispose an individual to bronchoconstriction following administration … |
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Mepolizumab May Substantially Reduce Asthma Exacerbations
JAMA: The Journal of the American Medical Association Mepolizumab, a humanized monoclonal antibody against interleukin-5, significantly reduced asthma exacerbations and improved quality of life among patients treated with inhaled glucocorticoids, according to a randomized, placebo-controlled trial with … |
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Clinical factors estimated risk for uncontrolled asthma, severe exacerbations
Healio Clinical factors were used to estimate risk for uncontrolled asthma and severe exacerbations, and to develop a risk score for future exacerbations, according to recent study results. Researchers conducted a retrospective analysis of data from three … |
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2 Minute Medicine |
Mepolizumab reduces exacerbations in severe eosinophilic asthma [MENSA trial]
2 Minute Medicine 1. The rate of asthma exacerbations was significantly reduced in patients with severe eosphinophilic asthma receiving either intravenous or subcutaneous mepolizumab, compared to patients receiving placebo. 2. The safety profile of mepolizumab was … Seven developments in asthma research |
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Teva's Reslizumab Shows Reduction In Asthma Exacerbations In Clinical Studies
RTT News Teva Pharmaceutical Industries Ltd. (TEVA: Quote) announced that reslizumab, an investigational anti-IL-5 monoclonal antibody, demonstrated clear levels of efficacy in achieving the primary endpoint of reduction in the frequency of clinical asthma … |
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Vitamin D, Asthma Exacerbations: Is There a Connection?
Monthly Prescribing Reference While a new study has found no significant association between serum 25OHD (vitamin D) levels and physician-diagnosed asthma, a strong association was seen between vitamin D levels and asthma exacerbations. Data reviewed on a cohort of adults aged … |
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Elevated blood eosinophil levels are a risk factor for asthma exacerbations
EurekAlert (press release) ATS 2014, SAN DIEGO ? In adults with persistent asthma, elevated blood eosinophil levels may be able to predict which individuals are at increased risk for exacerbations, according to a new study presented at the 2014 American Thoracic Society … |
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