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Heat induced asthma on a rise in the Bengaluru
Times of India "Dr H Paramesh, paediatric pulmonologist and director at Sirona Centre for Health Promotions, said: "Global warming is most dangerous for asthma patients as it increases the level of carbon dioxide in air and produces Ozone which affects the patients … |
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Condition: Bradycardia
Interventions: Drug: IM atropine; Drug: IV atropine; Drug: Atropine mixed with second dose succinylcholine; Drug: IM normal saline; Drug: IV normal saline; Drug: Normal saline mixed with second dose succinylcholine
Sponsor: Assiut University
Recruiting – verified February 2016
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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Related Articles |
MiR-23b controls TGF-?1 induced airway smooth muscle cell proliferation via TGF?R2/p-Smad3 signals.
Mol Immunol. 2015 Dec 31;70:84-93
Authors: Chen M, Huang L, Zhang W, Shi J, Lin X, Lv Z, Zhang W, Liang R, Jiang S
Abstract
BACKGROUND: Abnormal proliferation of ASM (airway smooth muscle) directly contributes to the airway remodeling during development of lung diseases such as asthma. Here we report that a specific microRNA (miR-23b) controls ASMCs proliferation through directly inhibiting TGF?R2/p-Smad3 pathway.
METHODS: The expression of miR-23b in ASMCs was detected by quantitative real-time polymerase chain reaction (RT-PCR). The effects of miR-23b on cell proliferation and apoptosis of ASMCs were assessed by transient transfection of miR-23b mimics and inhibitor. The target gene of miR-23b and the downstream pathway were further investigated.
RESULTS: Overexpression of miR-23b significantly inhibited TGF-?1-induced ASMCs proliferation and promoted apoptosis. RT-PCR and Western blotting analysis showed miR-23b negatively regulates the expression of TGF?R2 and p-Smad3 in ASMCs. Subsequent analyses demonstrated that TGF?R2 was a direct and functional target of miR-23b, which was validated by the dual luciferase reporter assay.
CONCLUSIONS: MiR-23b may function as an inhibitor of airway smooth muscle cells proliferation through inactivation of TGF?R2/p-Smad3 pathway.
PMID: 26748386 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
Conditions: Allergy; Asthma; Rhinitis
Interventions: Drug: Mitizax; Drug: Placebo
Sponsors: Abbott; Linical Co., Ltd; Datamap
Recruiting – verified November 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Conditions: Allergy; Asthma; Rhinitis
Interventions: Drug: Mitizax; Drug: Placebo
Sponsors: Abbott; Linical Co., Ltd; Datamap
Recruiting – verified November 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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Related Articles |
Bronchial lesions of mouse model of asthma are preceded by immune complex vasculitis and induced bronchial associated lymphoid tissue (iBALT).
Lab Invest. 2015 Jun 1;
Authors: Guest IC, Sell S
Abstract
We systematically examined by immune histology the lungs of some widely used mouse models of asthma. These models include sensitization by multiple intraperitoneal injections of soluble ovalbumin (OVA) or of OVA with alum, followed by three intranasal or aerosol challenges 3 days apart. Within 24?h after a single challenge there is fibrinoid necrosis of arterial walls with deposition of immunoglobulin (Ig) and OVA and infiltration of eosinophilic polymorphonuclear cells that lasts for about 3 days followed by peribronchial B-cell infiltration and slight reversible goblet cell hypertrophy (GCHT). After two challenges, severe eosinophilic vasculitis is present at 6?h, increases by 72?h, and then declines; B-cell proliferation and significant GCHT and hyperplasia (GCHTH) and bronchial smooth muscle hypertrophy recur more prominently. After three challenges, there is significantly increased induced bronchus-associated lymphoid tissue (iBALT) formation, GCHTH, and smooth muscle hypertrophy. Elevated levels of Th2 cytokines, IL-4, IL-5, and IL-13, are present in bronchial lavage fluids. Sensitized mice have precipitating antibody and positive Arthus skin reactions but also develop significant levels of IgE antibody to OVA but only 1 week after challenge. We conclude that the asthma like lung lesions induced in these models is preceded by immune complex-mediated eosinophilic vasculitis and iBALT formation. There are elevations of Th2 cytokines that most likely produce bronchial lesions that resemble human asthma. However, it is unlikely that mast cell-activated atopic mechanisms are responsible as we found only a few presumed mast cells by toluidine blue and metachromatic staining limited to the most proximal part of the main stem bronchus, and none in the remaining main stem bronchus or in the lung periphery.Laboratory Investigation advance online publication, 1 June 2015; doi:10.1038/labinvest.2015.72.
PMID: 26006019 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
WDBJ7 |
Symptoms of exercise induced asthma
WDBJ7 Doctors say exercise induced asthma can happen when you use your mouth to breathe more during your workout. Show Transcript Hide Transcript. In today's Hometown Health, we're hearing from health experts on a condition called exercise induced asthma … Health Minute: Feeling short of breath on your run? It could be exercise … |
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Greenville News |
Pollen and Exercise Induced Asthma
Greenville News Spring in Greenville is beautiful, but the layer of yellow pollen can cause issues – and not just for your car. Studies have shown that athletes – particularly endurance athletes – have a worse time with exercise induced asthma in the spring, when the … |
View full post on asthma – Google News
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Clinical assessment of speech correlates well with lung function during induced bronchoconstriction.
NPJ Prim Care Respir Med. 2015;25:15006
Authors: Tayler N, Grainge C, Gove K, Howarth P, Holloway J
Abstract
Clinical assessment of asthma often includes a crude assessment of speech, for example whether the patient can speak in full sentences. To date, this statement, despite appearing in national asthma guidelines, has not been related to lung function testing in asthma exacerbation. Seven asthmatics underwent a bronchial challenge and were then recorded reading a standardised text for 1?min. The recordings were played to 88 healthcare professionals who were asked to estimate FEV1% predicted. Health care professionals’ estimations showed moderate correlation to FEV1% predicted (rho=0.61 P<0.01). There were no significant differences between professionals grouped by seniority or speciality. Speech can intuitively be estimated by health care professionals with moderate accuracy. This gives an evidence basis for the assessment in speech in acute asthma and may provide a new avenue for monitoring.
PMID: 25719976 [PubMed – in process]
View full post on pubmed: asthma
Brisbane Times |
Asthma attacks to be induced in patients to test new gene-inhibiting treatment
ABC Online In a world first, Queensland researchers will induce asthma in patients to try and revolutionise the treatment of the condition. Researchers at QIMR Berghofer in Brisbane are trialling a drug that inhibits a gene found to be more active in people with … Arthritis drug may help treat asthma |
View full post on asthma – Google News