Breathe Well Live Well
Condition: Chronic Rhinosinusitis With Nasal Polyps
Interventions: Drug: Vitamin D; Drug: Budesonide Nasal Spray; Other: placebo
Sponsor: The First Affiliated Hospital of Shanxi Medical University
Not yet recruiting – verified January 2016
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
KING5.com |
Gut bacteria in infancy may influence asthma risk
KING5.com Bacteria, bugs in our gut, may influence a child's risk of developing asthma. The study followed over 300 Canadian children from birth onward, asking why do some kids get asthma while others don't? Genetics play a role but scientist say, to their … Study: Good gut bacteria may reduce babies' risk of asthma |
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Neurology Advisor |
Asthma May Influence Risk of Parkinson's Disease
Neurology Advisor HealthDay News — Patients with asthma may be at an increased risk of developing Parkinson's disease, according to a study published in Allergy. Chih-Ming Cheng, MD, from the Taipei Veterans General Hospital in Taiwan, and colleagues examined the … |
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The Influence of Setting on Care Coordination for Childhood Asthma.
Health Promot Pract. 2015 Jul 31;
Authors: Kelly RP, Stoll SC, Bryant-Stephens T, Janevic MR, Lara M, Ohadike YU, Persky V, Ramos-Valencia G, Uyeda K, Malveaux FJ
Abstract
Asthma affects 7.1 million children in the United States, disproportionately burdening African American and Latino children. Barriers to asthma control include insufficient patient education and fragmented care. Care coordination represents a compelling approach to improve quality of care and address disparities in asthma. The sites of The Merck Childhood Asthma Network Care Coordination Programs implemented different models of care coordination to suit specific settings-school district, clinic or health care system, and community-and organizational structures. A variety of qualitative data sources were analyzed to determine the role setting played in the manifestation of care coordination at each site. There were inherent strengths and challenges of implementing care coordination in each of the settings, and each site used unique strategies to deliver their programs. The relationship between the lead implementing unit and entities that provided (1) access to the priority population and (2) clinical services to program participants played a critical role in the structure of the programs. The level of support and infrastructure provided by these entities to the lead implementing unit influenced how participants were identified and how asthma care coordinators were integrated into the clinical care team.
PMID: 26232778 [PubMed – as supplied by publisher]
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Effect of different helminth extracts on the development of asthma in mice: the influence of early-life exposure and the role of IL-10 response.
Exp Parasitol. 2015 Jun 17;
Authors: Pitrez PM, Gualdi LP, Barbosa GL, Sudbrack S, Ponzi D, Cao RG, Silva AC, Machado DC, Jones MH, Stein RT, Graeff-Teixeira C
Abstract
It is not currently clear whether different parasites have distinct effects on the airway inflammatory response in asthma and whether exposure in early life to helminths have a stronger impact in a potential inhibitory effect on asthma. The aim of this study is to evaluate the effect of exposure to different helminth extracts on the development of allergic pulmonary response in mice, including early-life exposure. Different helminth extracts (Angiostrongylus costaricensis, Angiostrongylus cantonensis and Ascaris lumbricoides) were studied in female adult BALB/c and C57BL/6 IL-10-deficient mice in a protocol of murine asthma, injected intraperitoneally in different periods of exposure (early, pre-sensitization and post-sensitization). Cell counts in bronchoalveolar lavage (BAL), eosinophil peroxidase (EPO) from lung tissue, cytokine levels from BAL/spleen cell cultures, and lung histology were analyzed. Airway cellular influx induced by OVA was significantly inhibited by extracts of A. cantonensis and A. lumbricoides. Extracts of A. lumbricoides and A. costaricensis led to a significant reduction of IL-5 in BAL (p<0.001). Only the exposure to A. lumbricoides led to an increased production of IL-10 in the lungs (p<0.001). In IL-10-deficient mice exposed to A. costaricensis pre-sensitization, eosinophil counts and IL-5 levels in BAL and EPO in lung tissue were significantly reduced. In the early exposure to A. cantonensis, lung inflammation was clearly inhibited. In conclusion, different helminth extracts inhibit allergic lung inflammation in mice. IL-10 may not play a central role in some helminth-host interactions. Early exposure to helminth extracts could be a potential strategy to explore primary prevention in asthma.
PMID: 26093162 [PubMed – as supplied by publisher]
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Confounding familial factors could influence link between antibiotics …
Healio “Our results indicate that there is no causal link between antibiotics treatment and childhood asthma,” researcher Catarina Almqvist Malmros, MD, PhD, pediatrician and professor at the department of medical epidemiology and Biostatistics, Karolinska … |
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The Influence of Particulate Matter on Respiratory Morbidity and Mortality in Children and Infants.
Adv Exp Med Biol. 2014 Nov 9;
Authors: Jakubiak-Lasocka J, Lasocki J, Badyda AJ
Abstract
Air pollution is the most important environmental health risk leading to premature mortality, respiratory and other health problems. The aim of this study was to quantify its impact on infants and children in Warsaw (Poland), following the principles of Health Impact Assessment method. Particulate matter (PM2.5 and PM10) was considered as the indicator of air pollution. Exposure-response functions between air pollution and health impacts were employed based on the literature. According to the calculations, around 5,201 asthma symptoms and 234 hospital respiratory admissions were caused annually due to air pollution. Hospitalizations due to cardiovascular problems related to air pollution amounted to 13. The mortality among infants and children is relatively low and occurs mostly in the postneonatal period. Nonetheless, approx. 5 mortality cases were assessed to be air pollution-attributable. The study demonstrates a significant impact of air pollution on infants and children, which is manifested primarily as a range of respiratory problems.
PMID: 25381559 [PubMed – as supplied by publisher]
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Socioeconomic inequalities influence overall outcomes for children with asthma
News-Medical.net According to the Centers for Disease Control and Prevention (CDC), approximately 6 percent of children younger than five have been diagnosed with asthma, the fastest-growing and most common chronic illness affecting children in the United States … |
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Influence of farming exposure on the development of asthma and asthma-like symptoms.
Int Immunopharmacol. 2014 Jul 30;
Authors: Wells AD, Poole JA, Romberger DJ
Abstract
Based upon age and type of farming exposures, a wide range of studies demonstrate either protective or deleterious effects of the farming environment on asthma. In this review, we highlight key studies supporting the concept that farming exposure protects children from asthma and atopy based on studies performed largely in European pediatric cohorts. Various types of farming in certain regions appear to have a greater effect on asthma protection, as does the consumption of unpasteurized milk. In the United State, where concentrated animal feeding operations (CAFOs) are more common, asthma is increased in children exposed especially to swine CAFOs; whereas, rates of atopy and allergy are lower in these children. We also review studies evaluating the role of farming exposures both as a child and/or as an adult on asthma seen in adults. The importance of microbes in farming environments and the contribution of various components of the innate immune system including toll-like receptors to the underlying mechanisms of asthma related to farming exposures are also reviewed.
PMID: 25086344 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
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New research reveals how expectations about odors can influence symptoms of …
News-Medical.net Asthma is a chronic inflammatory disorder of the lungs. According to the National Institutes of Health, over 25 million Americans have the disease, which can interfere with quality of life. The airways of asthmatics are sensitive to 'triggers' that … |
View full post on asthma – Google News