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WTAJ |
Mice Linked to Asthma Attacks
WTAJ Cockroaches may be getting a bad rap, when it comes to who's responsible for causing asthma symptoms in children. A new study found that children,who are allergic to mice were more likely to be have had at least one asthma-related emergency department … |
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No Adjuvant Effect of Bacillus thuringiensis-Maize on Allergic Responses in Mice.
PLoS One. 2014;9(8):e103979
Authors: Reiner D, Lee RY, Dekan G, Epstein MM
Abstract
Genetically modified (GM) foods are evaluated carefully for their ability to induce allergic disease. However, few studies have tested the capacity of a GM food to act as an adjuvant, i.e. influencing allergic responses to other unrelated allergens at acute onset and in individuals with pre-existing allergy. We sought to evaluate the effect of short-term feeding of GM Bacillus thuringiensis (Bt)-maize (MON810) on the initiation and relapse of allergic asthma in mice. BALB/c mice were provided a diet containing 33% GM or non-GM maize for up to 34 days either before ovalbumin (OVA)-induced experimental allergic asthma or disease relapse in mice with pre-existing allergy. We observed that GM-maize feeding did not affect OVA-induced eosinophilic airway and lung inflammation, mucus hypersecretion or OVA-specific antibody production at initiation or relapse of allergic asthma. There was no adjuvant effect upon GM-maize consumption on the onset or severity of allergic responses in a mouse model of allergic asthma.
PMID: 25084284 [PubMed – in process]
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Mycoplasma pneumoniae CARDS Toxin Exacerbates Ovalbumin-Induced Asthma-Like Inflammation in BALB/c Mice.
PLoS One. 2014;9(7):e102613
Authors: Medina JL, Coalson JJ, Brooks EG, Le Saux CJ, Winter VT, Chaparro A, Principe MF, Solis L, Kannan TR, Baseman JB, Dube PH
Abstract
Mycoplasma pneumoniae causes a range of airway and extrapulmonary pathologies in humans. Clinically, M. pneumoniae is associated with acute exacerbations of human asthma and a worsening of experimentally induced asthma in mice. Recently, we demonstrated that Community Acquired Respiratory Distress Syndrome (CARDS) toxin, an ADP-ribosylating and vacuolating toxin synthesized by M. pneumoniae, is sufficient to induce an asthma-like disease in BALB/cJ mice. To test the potential of CARDS toxin to exacerbate preexisting asthma, we examined inflammatory responses to recombinant CARDS toxin in an ovalbumin (OVA) murine model of asthma. Differences in pulmonary inflammatory responses between treatment groups were analyzed by histology, cell differentials and changes in cytokine and chemokine concentrations. Additionally, assessments of airway hyperreactivity were evaluated through direct pulmonary function measurements. Analysis of histology revealed exaggerated cellular inflammation with a strong eosinophilic component in the CARDS toxin-treated group. Heightened T-helper type-2 inflammatory responses were evidenced by increased expression of IL-4, IL-13, CCL17 and CCL22 corresponding with increased airway hyperreactivity in the CARDS toxin-treated mice. These data demonstrate that CARDS toxin can be a causal factor in the worsening of experimental allergic asthma, highlighting the potential importance of CARDS toxin in the etiology and exacerbation of human asthma.
PMID: 25058417 [PubMed – in process]
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mtDNA sequence, phylogeny and evolution of laboratory mice.
Mitochondrion. 2014 Jul 16;
Authors: Zheng J, Chen Y, Deng F, Huang R, Petersen F, Ibrahim S, Yu X
Abstract
Laboratory mice are important tools for biomedical research. Aiming to investigate the phylogeny and evolution of laboratory mice, we investigated the mtDNA sequences of classical inbred strains, classical outbred stocks and wild-derived inbred strains. Our results showed that the most classical outbred stocks and classical inbred strains are descended from a single mtDNA ancestor. The phylogenic analysis supports the topology of M. m. castaneus / M. m. domesticus as sister subspecies, and the divergence time between the two sister subspecies and M. m. musculus was 493,000 (435,000-557,000) years ago. Furthermore, the mtDNA polymorphisms accumulated in the last 100years in the laboratory mice are under a relaxed purifying selection.
PMID: 25038446 [PubMed – as supplied by publisher]
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Voice of America |
Fiber-Munching Mice Avoid Asthma
Scientific American Fiber-Munching Mice Avoid Asthma. Mice fed a fiber-rich diet were more resistant to allergy-induced airway inflammation, thanks to happy gut bacteria that produce fatty acids that calm the immune system. Sophie Bushwick reports. Dietary Fiber May Prevent Asthma Fiber-Rich Diet Cuts Asthma in Mice Can eating produce help with asthma? |
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Mice fed a fiber-rich diet were more resistant to allergy-induced airway inflammation, thanks to happy gut bacteria that produce fatty acids that calm the immune system. Sophie Bushwick reports.
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Mother Nature Network (blog) |
Fiber-Rich Diet Cuts Asthma in Mice
Scientist WIKIMEDIA, JON SULLIVANAsthma rates in Western countries have surged in recent decades, perhaps in part because of eating habits that largely ignore fiber. Researchers have shown that mice fed a low-fiber diet reacted more strongly with asthma-like … Can eating produce help with asthma? Eating more fruit and vegetables may help with asthma Dietary Fiber Found In Fruits And Vegetables Help Protect Against Asthma |
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Mice Eases Asthma Symptoms
spyghana.com Asthma Fruits, vegetables and whole-grains might be an unlikely treatment for asthma according to animal studies. Tests on mice, published in the journal Nature Medicine, showed that a high-fibre diet could reduce inflammation in the lungs. The extra … |
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Influence of the Adjuvants and Genetic Background on the Asthma Model Using Recombinant Der f 2 in Mice.
Immune Netw. 2013 Dec;13(6):295-300
Authors: Chang YS, Kim YK, Jeon SG, Kim SH, Kim SS, Park HW, Min KU, Kim YY, Cho SH
Abstract
Der f 2 is the group 2 major allergen of a house dust mite (Dermatophagoides farinae) and its function has been recently suggested. To determine the optimal condition of sensitization to recombinant Der f 2 (rDer f 2) in murine model of asthma, we compared the effectiveness with different adjuvants in BALB/c and C57BL/6 mice. Mice from both strains sensitized with rDer f 2 by intraperitoneal injection or subcutaneous injection on days 1 and 14. The dosage was 20 µg. Freund’s adjuvants with pertussis toxin (FP) or alum alone were used as adjuvants. On days 28, 29, and 30, mice were challenged intranasally with 0.1% rDer f 2. We evaluated airway hyperresponsivenss, eosinophil proportion in lung lavage, airway inflammation, and serum allergen specific antibody responses. Naive mice were used as controls. Airway hyperresponsiveness was increased in C57BL/6 with FP, and BALB/c with alum (PC200: 13.5±6.3, 13.2±6.7 vs. >50 mg/ml, p<0.05). The eosinophil proportion was increased in all groups; C57BL/6 with FP, BALB/c with FP, C57BL/6 with alum, BALB/c with alum (24.8±3.6, 20.3±10.3, 11.0±6.9, 5.7±2.8, vs. 0.0±0.0%, p<0.05). The serum allergen specific IgE levels were increased in C57BL/6 with FP or alum (OD: 0.8±1.4, 1.1±0.8, vs. 0.0±0.0). C57BL/6 mice were better responders to rDer f 2 and as for adjuvants, Freund’s adjuvant with pertussis toxin was better.
PMID: 24385949 [PubMed]
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NBCNews.com |
Mold, mice and zip codes: Inside the childhood asthma epidemic
NBCNews.com Though mold covers the ceiling and walls of Sepulveda's bathroom—and most likely has exacerbated Melissa's asthma—his landlord, the New York City Housing Authority, has been slow to make the necessary repairs that would get rid of it, according to … |
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