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Asthma Associated With Increased Risk of Obstructive Sleep Apnea
Newswise (press release) Newswise — Participants in a sleep study who had asthma had an increased risk for developing obstructive sleep apnea, with this association stronger with having had asthma longer, according to a study in the January 13 issue of JAMA. In adults … |
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Lung Disease News |
Asthmatics At Greater Risk Of Developing Obstructive Sleep Apnea Researchers …
Lung Disease News Sleep Apnea An Original Investigation paper published in the January 13 issue of JAMA – The Journal Of The American Medical Association reports that sleep study participants who were also asthmatic were observed to be at increased risk for developing … Asthma Linked With Increased Obstructive Sleep Apnea Risk |
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2 Minute Medicine |
Asthma linked to risk of new-onset obstructive sleep apnea
2 Minute Medicine Although certain risk factors such as obesity, craniofacial structural issues and alcohol use have been established as risk factors, the causal relationship of asthma to developing OSA has not been well elucidated. Various studies have suggested a … |
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Economy Lead |
Study finds that asthma may increase obstructive sleep apnea risk
News-Medical.net Participants in a sleep study who had asthma had an increased risk for developing obstructive sleep apnea, with this association stronger with having had asthma longer, according to a study in the January 13 issue of JAMA. In adults, obstructive sleep … Asthma Tied to Higher Risk of Sleep Apnea Asthma may add to sleep apnea risk Asthma May Boost Sleep Apnea Risk |
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Medical Xpress |
Asthma associated with increased risk of obstructive sleep apnea
Medical Xpress Twenty-two of 81 participants (27 percent) with asthma experienced incident OSA over their first observed 4-year follow-up intervals vs 75 of 466 participants (16 percent) without asthma. Using all available 4-year intervals (i.e., including multiple 4 … |
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Conditions: Pulmonary Disease, Chronic Obstructive; Overweight
Interventions: Dietary Supplement: Resveratrol; Dietary Supplement: Placebo
Sponsors: Maastricht University Medical Center; The Netherlands Asthma Foundation; DSM Nutritional Products, Inc.
Not yet recruiting – verified September 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Condition: Pulmonary Disease, Chronic Obstructive
Interventions: Drug: Mepolizumab; Drug: Placebo
Sponsor: GlaxoSmithKline
Not yet recruiting – verified April 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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Related Articles |
The Involvement of Phospholipases A 2 in Asthma and Chronic Obstructive Pulmonary Disease.
Mediators Inflamm. 2013;2013:793505
Authors: Pniewska E, Pawliczak R
Abstract
The increased morbidity, mortality, and ineffective treatment associated with the pathogenesis of chronic inflammatory diseases such as asthma and chronic obstructive pulmonary disease (COPD) have generated much research interest. The key role is played by phospholipases from the A2 superfamily: enzymes which are involved in inflammation through participation in pro- and anti-inflammatory mediators production and have an impact on many immunocompetent cells. The 30 members of the A2 superfamily are divided into 7 groups. Their role in asthma and COPD has been studied in vitro and in vivo (animal models, cell cultures, and patients). This paper contains complete and updated information about the involvement of particular enzymes in the etiology and course of asthma and COPD.
PMID: 24089590 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
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Predictors of cardiovascular disease in asthma and chronic obstructive …
7thSpace Interactive (press release) Cardiovascular disease (CVD) is a common comorbidity in patients with chronic airway obstruction, and is associated with systemic inflammation and airway obstruction. The aim of this study was to evaluate the predictors of CVD in two different … |
View full post on asthma – Google News
| Related Articles |
Day-to-day measurement of patient-reported outcomes in exacerbations of chronic obstructive pulmonary disease.
Int J Chron Obstruct Pulmon Dis. 2013;8:273-86
Authors: Kocks JW, van den Berg JW, Kerstjens HA, Uil SM, Vonk JM, de Jong YP, Tsiligianni IG, van der Molen T
Abstract
BACKGROUND: Exacerbations of chronic obstructive pulmonary disease (COPD) are a major burden to patients and to society. Little is known about the possible role of day-to-day patient-reported outcomes during an exacerbation. This study aims to describe the day-to-day course of patient-reported health status during exacerbations of COPD and to assess its value in predicting clinical outcomes.
METHODS: Data from two randomized controlled COPD exacerbation trials (n = 210 and n = 45 patients) were used to describe both the feasibility of daily collection of and the day-to-day course of patient-reported outcomes during outpatient treatment or admission to hospital. In addition to clinical parameters, the BORG dyspnea score, the Clinical COPD Questionnaire (CCQ), and the St George’s Respiratory Questionnaire were used in Cox regression models to predict treatment failure, time to next exacerbation, and mortality in the hospital study.
RESULTS: All patient-reported outcomes showed a distinct pattern of improvement. In the multivariate models, absence of improvement in CCQ symptom score and impaired lung function were independent predictors of treatment failure. Health status and gender predicted time to next exacerbation. Five-year mortality was predicted by age, forced expiratory flow in one second % predicted, smoking status, and CCQ score. In outpatient management of exacerbations, health status was found to be less impaired than in hospitalized patients, while the rate and pattern of recovery was remarkably similar.
CONCLUSION: Daily health status measurements were found to predict treatment failure, which could help decision-making for patients hospitalized due to an exacerbation of COPD.
PMID: 23766644 [PubMed – in process]
View full post on pubmed: asthma