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Respiratory therapist: Asthma can worsen in hot weather
WITN With a heat index reaching the triple digits in some areas on Thursday, those with asthma need to be careful. Asthma specialists say parents with children who have the condition need to be especially careful on hot days. With summer creeping up … |
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Conditions: Chronic Obstructive Pulmonary Disease (COPD); Asthma; Bronchiectasis
Intervention:
Sponsors: Portsmouth Hospitals NHS Trust; University of Portsmouth
Completed – verified June 2015
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NSAID-exacerbated respiratory disease prevalent with asthma
Medical Xpress (HealthDay)—Among people with asthma, the prevalence of nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (NERD) is about 9 percent, and asthma morbidity is increased among those with NERD, according to a review published online … |
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NSAID-Exacerbated Respiratory Disease Prevalent With Asthma
Monthly Prescribing Reference (HealthDay News) — Among people with asthma, the prevalence of nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (NERD) is about 9 percent, and asthma morbidity is increased among those with NERD, according to a review published … |
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The Influence of Particulate Matter on Respiratory Morbidity and Mortality in Children and Infants.
Adv Exp Med Biol. 2014 Nov 9;
Authors: Jakubiak-Lasocka J, Lasocki J, Badyda AJ
Abstract
Air pollution is the most important environmental health risk leading to premature mortality, respiratory and other health problems. The aim of this study was to quantify its impact on infants and children in Warsaw (Poland), following the principles of Health Impact Assessment method. Particulate matter (PM2.5 and PM10) was considered as the indicator of air pollution. Exposure-response functions between air pollution and health impacts were employed based on the literature. According to the calculations, around 5,201 asthma symptoms and 234 hospital respiratory admissions were caused annually due to air pollution. Hospitalizations due to cardiovascular problems related to air pollution amounted to 13. The mortality among infants and children is relatively low and occurs mostly in the postneonatal period. Nonetheless, approx. 5 mortality cases were assessed to be air pollution-attributable. The study demonstrates a significant impact of air pollution on infants and children, which is manifested primarily as a range of respiratory problems.
PMID: 25381559 [PubMed – as supplied by publisher]
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Zinc oxide nanoparticles affect the expression of p53, Ras p21 and JNKs: an ex vivo/in vitro exposure study in respiratory disease patients.
Mutagenesis. 2014 Nov 6;
Authors: Kumar A, Najafzadeh M, Jacob BK, Dhawan A, Anderson D
Abstract
Zinc oxide (ZnO) nanoparticles are the mostly used engineered metal oxide nanoparticles in consumer products. This has increased the likelihood of human exposure to this engineered nanoparticle (ENPs) through different routes. At present, the majority of the studies concerning ZnO ENPs toxicity have been conducted using in vitro and in vivo systems. In this study, for the first time we assessed the effect of ZnO ENPs on the major cellular pathways in the lymphocytes of healthy individuals as well as in susceptible patients suffering from lung cancer, chronic obstructive pulmonary disease (COPD) and asthma. Using the differential expression analysis, we observed a significant (P < 0.05) dose-dependent (10, 20 and 40 µg/ml for 6h) increase in the expression of tumour suppressor protein p53 (40, 60 and 110%); Ras p21 (30, 52 and 80%); c-Jun N-terminal kinases; JNKs) (28, 47 and 78%) in lung cancer patient samples treated with ZnO ENPs compared to healthy controls. A similar trend was also seen in COPD patient samples where a significant (P < 0.05) dose-dependent increase in the expression of tumour suppressor protein p53 (26, 45 and 84%), Ras p21 (21, 40 and 77%), JNKs (17, 32 and 69%) was observed after 6h of ZnO ENPs treatment at the aforesaid concentrations. However, the increase in the expression profile of tested protein was not significant in the asthma patients as compared to controls. Our results reiterate the concern about the safety of ZnO ENPs in consumer products and suggest the need for a complete risk assessment of any new ENPs before its use.
PMID: 25381309 [PubMed – as supplied by publisher]
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Treatment of Aspirin Exacerbated Respiratory Disease with a Low Salicylate Diet: A Pilot Crossover Study.
Otolaryngol Head Neck Surg. 2014 Oct 24;
Authors: Sommer DD, Hoffbauer S, Au M, Sowerby LJ, Gupta MK, Nayan S
Abstract
OBJECTIVE: Aspirin exacerbated respiratory disease (AERD) is comprised of aspirin/acetylsalicylic acid (ASA) sensitivity, bronchial asthma, and nasal polyposis. Treatment of this condition is challenging and may include topical/systemic steroids, endoscopic sinus surgery, and/or aspirin desensitization.
STUDY DESIGN: A prospective crossover pilot study (n = 10) was conducted in which patients were randomized into either of 2 groups with 6 weeks of regular diet (R) or 6 weeks of a low salicylate diet (LS).
SETTING: The study was conducted in a tertiary otolaryngology clinic.
SUBJECTS: Patients with AERD were enrolled in the study.
METHODS: Subjective (Sino-nasal Outcome Test-22 [SNOT-22], Nasal Sinus Symptom Scale [NSSS], and the Asthma Control Questionnaire-7 [ACQ-7]) and objective outcome instruments (Peri-Operative Sinus Evaluation [POSE] and Lund-Kennedy Endoscopic Score [LKES]) were used to evaluate patients at baseline, 6 weeks (at crossover), and 12 weeks.
RESULTS: Wilcoxon rank sum tests demonstrated that patients on the low salicylate diet had improved scores compared to their regular diet when evaluated by 4 of the 5 outcome measures (SNOT-22 pLS = 0.0059, NSSS pLS = 0.0195, LKES pLS = 0.0039, POSE pLS = 0.005).
CONCLUSION: Results of the pilot study indicate that implementation of a low salicylate diet improves the nasal symptoms and nasal endoscopy findings of individuals with AERD. Further research is required to support these findings.
PMID: 25344589 [PubMed – as supplied by publisher]
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New York Times |
Docs Offer Advice for Combating Respiratory Virus That's Striking Kids
Philly.com "Children with pre-existing lung conditions, such as asthma, appear to be at the greatest risk for severe symptoms from this virus. Most EV-D68 infected children recover without serious illness," Dr. Albert Rizzo, senior medical advisor at the American … San Juan County hit by first case of D68 enterovirus Ontario County confirms adult case of Enterovirus D68 Ontario County adult has confirmed case of enterovirus (EV-D68) |
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Related Articles |
Caesarean Section and Hospitalization for Respiratory Syncytial Virus Infection: A Population Based Study.
Pediatr Infect Dis J. 2014 Sep 17;
Authors: Kristensen K, Fisker N, Haerskjold A, Ravn H, Simões EA, Stensballe L
Abstract
BACKGROUND AND OBJECTIVE:: Hospitalization for respiratory syncytial virus (RSV) infection and asthma share common determinants, and meta-analyses indicate that children delivered by caesarean section (CS) are at increased risk of asthma. We aimed to investigate whether birth by CS is associated with an increased risk of hospitalization for RSV illness.
METHODS:: This was a population based national register based cohort study, conducted between January 1997 and June 2003, that included all children born in Denmark and all hospitalizations for RSV disease in them from 0 – 23 months of age. We used Cox regression with adjustment for prematurity, asphyxia, birth weight, multiple births, single parenthood, maternal smoking during pregnancy, older siblings, and asthma diagnoses up to 2 weeks before hospitalization for RSV infection, to compare the effects of acute or elective CS versus vaginal delivery, on subsequent hospitalization for RSV disease. A test for homogeneity was used to assess for effect over time.
RESULTS:: 399,175 children with 10,758 hospitalizations for RSV illness were included. 31,715 were born by acute CS and 30,965 by elective CS. Adjusted hazard ratios for hospitalization for RSV infection in children born by acute CS and by elective CS were 1.09 (1.01 – 1.17) and 1.27 (1.19 – 1.36), respectively. The effect of elective CS remained unchanged throughout the first two years of life (p = 0.53), whereas the effect of acute CS was only present in the second year of life (p = 0.001).
CONCLUSION:: Delivery by caesarian section is associated with an increased risk of hospitalization for RSV infeciton. This effect continues at least throughout the first two years of life.
PMID: 25232778 [PubMed – as supplied by publisher]
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Kids with asthma or wheezing face most danger from respiratory virus
NorthJersey.com Despite the vast amount of attention that's been focused on the danger enterovirus-68 poses to children, the reality is that for most kids, the respiratory virus wouldn't be much tougher than a bout with the common cold. About a dozen cases of the … |
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